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Propafenone associated granulocytopenia in a newborn

Published online by Cambridge University Press:  19 August 2008

Thomas Paul ,
Ingrid Luhmer  and
Alfred Reiter
Thomas Paul*
Affiliation:
From the Department of Pediatric CardiologyChildren’s Hospital, Hannover Medical School, Hannover, Federal Republic of Germany
Ingrid Luhmer
Affiliation:
From the Department of Pediatric CardiologyChildren’s Hospital, Hannover Medical School, Hannover, Federal Republic of Germany
Alfred Reiter
Affiliation:
Department of Pediatric Hematology and Oncology, Children’s Hospital, Hannover Medical School, Hannover, Federal Republic of Germany
*
Dr. Thomas Paul, Pediatric Cardiology, Children's Hospital, Hannover Medical School, D-30623 Hannover, FR Germany. Tel. 0049-511-5323220; Fax. 0049-511-5329038.
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Abstract

Progressive granulocytopenia (neutrophil count <1000/ml) developed in a newborn during treatment with propafenone (200 mg/m2) for recurrent paroxysmal supraventricular tachycardia. The total white blood cell count, however, remained within normal limits. The neutrophil count increased gradually after propafenone had been stopped. The time course of treatment and the development of granulocytopenia make it very likely, but not certain, that propafenone was the responsible agent. Pediatricians, and especially pediatric cardiologists, should be aware of this rare adverse effect when they consider treatment with propafenone in children with cardiac arrhythmias. Analysis of the white cell blood count, including a differential count, is recommended in all children in order to assess the true incidence of this adverse effect.

Keywords

Propafenonegranulocytopeniaadverse drug effects
Type
Brief Reports
Information
Cardiology in the Young , Volume 6 , Issue 4 , October 1996 , pp. 348 - 349
Copyright
Copyright © Cambridge University Press 1996

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References

1.Reimer, A, Paul, T, Kallfelz, HC. Efficacy and safety of intrave nous and oral propafenone in pediatric cardiac dysrhythmias. Am J Cardiol 1991; 68: 741–744.CrossRefGoogle Scholar
2.Guccione, P, Drago, F, Di Donato, RM, Cicini, MP, Pasquini, L, Marino, B, Marcelletti, C, Ragonese, P. Oral propafenone therapy for children with arrhythmias: Efficacy and adverse effects in mid-term follow-up. Am Heart J 1991; 122: 1022–1027.CrossRefGoogle Scholar
3.Janousek, J, Paul, T, Reimer, A, Kallfelz, HC. Usefulness of propafenone for supraventricular arrhythmias in infants and children. Am J Cardiol 1993; 72: 294–300.CrossRefGoogle ScholarPubMed
4.Paul, T, Janousek, J. New antiarrhythmic drugs in pediatric use: Propafenone. Pediatr Cardiol 1994; 15: 190–197.CrossRefGoogle ScholarPubMed
5.Janousek, J, Paul, T. AEPC Investigators. Propafenone safety in pediatric dysrhythmias-European retrospective multicenter study. Cardiol Young 1994; 4 (Suppl 1): 12.Google Scholar
6.Lucet, V, Do Ngoc, D, Fidelle, J, Sidi, D, Barisse, A, Loth, P, Vrancea, F, Villain, E, Coumel, P. Efficacite anti-arrhythmique de la propafenone chez l'enfant. Arch Mai Coeur 1987; 80: 1385–1393.Google Scholar
7.Miwa, LJ, Jolson, HM. Propafenone associated agranulocytosis. PACE 1992; 15:387–390.CrossRefGoogle ScholarPubMed
8.Mayrhofer, EF, Davogg, S, Feilhauer, GD, Pilecky, I, Seisenbacher, H, Vockner, H. Fallbericht einer schweren, moglicherweise propafenonverursachten Granulozytopenie.Wien Med Wschr 1982; 11:272–275.Google Scholar
9.Ravid, S, Podrid, PJ, Novrit, B. Safety of long-term propafenone therapy for cardiac arrhythmia—experience with 774 patients. J Eiectrophysiol 1987; 1: 580–590.CrossRefGoogle Scholar
10.Cumutte, JT, Boxer, LA. Disorders of granulopoiesis. In: Nathan, DG, Oski, FA (eds). Hematology of Infancy and Childhood. W.B. Saunders, Philadelphia, 1987, pp 797–847.Google Scholar