Hostname: page-component-cd9895bd7-7cvxr Total loading time: 0 Render date: 2024-12-23T00:03:52.540Z Has data issue: false hasContentIssue false
  • English
  • Français

Prevalence at birth, “natural” risk and survival with atrioventricular septal defect

Published online by Cambridge University Press:  19 August 2008

Milan Samaánek
Milan Samaánek*
Affiliation:
Kardiocentrum, University Hospital Motol, Prague
*
Professor Doctor Milan Samánek, Kardiocentrum, Fakultni Nemocnice Motol, 15018 Praha 5, Czechoslovakia
Get access Rights & Permissions [Opens in a new window]

Summary

Prevalence of atrioventricular septal defect in liveborn infants at birth was calculated in Bohemia (population of 6.3 million). Of 664,208 liveborn infants, 4,409 had a congenital malformation of the heart and in 126 of them (0.19/1,000 live births, 2.9% of all heart defects) this was found to be an atrioventricular septal defect. The ratio between those with a common valvar orifice (complete form) versus those with separate right and left atrioventricular valvar orifices (incomplete form) was 1.14:1. The ratio of girls to boys was 1.17:1. Children born in March, July and October were more likely to have the defect (0.26/1,000 live births) than those born in May (0.10/ 1,000 live births). The defect was the eighth most frequent critical congenital cardiac malformation. Eight in each 100,000 liveborn children, and 3.56% of all patients with congenital cardiac disease, are at high risk of dying due to deficient atrioventricular septation, which in 82.5% resulted in the presence of a common atrioventricular valve (complete form). Unconditional death rate was studied in 1,008 liveborn children who died with a cardiac malformation before the age of 15 before the advent of cardiac surgery. Of these, 64 (6.35%) died with an atrioventricular septal defect which was complete in 5.95% and incomplete in 0.40%. All but one of 60 children with the complete form (common atrioventricular valve) died in the first year of life. The last child died between the age of 2 and 5 years. The estimate for natural survival was calculated using our own data on the prevalence and age distribution of mortality. Of all the liveborn children with atrioventricular septal defect, 91% are expected to survive the first month, 81% (78−85) the first trimester, 63% (56−69) six months, and 49% (35−54) the first year. The survival curve remains stable thereafter.

Type
The World Forum for Pediatric Cardiology Symposium on Atrioventricular Septal Defect
Information
Cardiology in the Young , Volume 1 , Issue 4 , October 1991 , pp. 285 - 289
Copyright
Copyright © Cambridge University Press 1991

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Kenna, AP, Smithels, RW, Fielding, DW.Congenital heart disease in Liverpool. QuartJ Med 1975; 173: 17–44.Google Scholar
Nakazawa, M, Seguchi, M, Takao, A. Prevalence of congenital heart disease in Japan. Proceedings of the third symposium on etiology and morphogenesis of congenital heart disease, 1988, pp 105–106.Google Scholar
Rose, V, Boyd, ARH, Ashton, TE.Incidence of heart disease in children in the city ofToronto. Can MedAssocJ 1964; 91:95–100.Google Scholar
Ferencz, C, Rubin, JD, McCarter, RJ, Brenner, JI, Neill, CA, Perry, LW, Hepner, SI, Downing, JW.Congenital heart disease: prevalence at livebirth. Am J Epidemiol 1985; 121: 31–36.Google Scholar
Samánek, M, Slavík, Z. Congenital heart disease-incidence seasonal and regional differences. Acta Universitatis Carolinae. [in press]Google Scholar
Samánek, M, VorIsková, M.Infants with critical heart disease in a territory with centralized care. Int J Cardiol 1987; 16: 75–91.Google Scholar
Samánek, M.Survival of children born with congenital heart defect.In: Pongpanich, B, Sueblinvong, V, Vongprateep, Ch (eds). Pediatric Cardiology, Excerpta Medica, Amsterdam-New York-Oxford, 1990, pp 343–346.Google Scholar
Muir, CS.Incidence of congenital heart disease in Singapore. Br Heart J 1966; 22: 243–254.Google Scholar
Carlgren, LE.Incidence of congenital heart disease in children born in Gothenburg. Br Heart J 1959; 21: 40–50.Google Scholar
Laursen, HB.Some epidemiological aspects of congenital heart disease in Denmark. Acta Paediatr Scand 1980; 69: 619–624.Google Scholar
Gasul, BM, Arcilla, RE, Lev, M.Heart disease in children. JB Lippincott Co, Philadelphia and Montreal,1966.Google Scholar
Mitchell, SC, Korones, SB, Berendas, HW.Congenital heart disease in 56,109 births: Incidence and natural history. Circulation 1971; 43: 323–332.Google Scholar
Bound, JP, Logan, WFWE.Incidence of congenital heart disease in Blackpool 1947–1971. Br Heart J 1977; 39: 445–450.Google Scholar
Hoffman, JIE, Christianson, R.Congenital heart disease in a cohort of 19,502 births with long-term follow-up. Am J Cardiol 1978; 42: 641–647.Google Scholar
Feldt, KH, Avasthey, P.Yoshimasu, F, Kurland, LT, Titus, JL.Incidence of congenital heart disease in children born to residents of Olmstead County, Minnesota 1950–1969. Mayo Clin Proc 1971; 46: 794–799.Google Scholar
Dickinson, DF, Arnold, R, Wilkinson, JL.Congenital heart disease among 160,480 liveborn children in Liverpool 1960 to 1969. Br Heart J 1981; 46: 55–62.Google Scholar
Bull, C, Shinebourne, EA. Complete atrioventricular septal defect. Medical versus surgical treatment (1981–1983). In: Quero-Jiménez, M, Arteaga-Martínez, M (eds). Paediatric Cardiology. Atrioventricularseptal defects. Ediciones Norma, Madrid, 1988.Google Scholar
Frontera-Izqwerdo, P, Gabezuelo-Huerta, G.Natural and modi hed history of complete atrioventricular septal defect - a 17 year study. Arch Dis Child 1990; 65: 964–967.Google Scholar
Berger, TJ, Blackstone, EH, Kirklin, JW, Bargeron, LM, Hazelrig, JB, Turner, ME.Survival and probability of cure without and with operation in complete atrioventricular canal. Am Thor Surg 1979; 27: 104–111.Google Scholar
Samánek, M, Benesová, D, Goerzová, J, Hrycejová, I.Distribution of age at death in children with congenital heart disease who died before the age of 15. Br Heart J 1988; 59: 581–585.Google Scholar
Weyn, AS, Bartle, SH, Nolan, TB, Damman, JF.Atrial septal defect-primum type. Circulation 1965; 32 (Suppl III): IIIyes13–23.Google Scholar
Somerville, J, Revel-Chion, R, Van Der Cammen, T, Presbitero, P.Atrioventricular defects-natural and unnatural history In: Godman, MH (ed). Paediatric Cardiology. Churchill Livingstone, Edinburgh, 1981, pp 404–416.Google Scholar
Heath, D.Long term survival in partial persistent common atrioventricular canal. Br J Dis Chest 1968; 62: 207–215.Google Scholar
Hynes, JK, Tajik, AJK, Seward, JB, McGoon, DC.Partial atrioventricular canal defect in elderly patients (aged 60 years or older). Am J Cardiol 1982; 50: 59–62.Google Scholar
Sebek, A, Procházka, Z.Vrozená srdecní vada u srarého muze. Plzensky Lék Sbor 1959; 10: 173. [English Summary]Google Scholar