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Post-catheterisation arterial thrombosis in children – pathophysiology, prevention, and treatment

Published online by Cambridge University Press:  27 February 2014

João Silva Marques  and
Cristina Gonçalves
João Silva Marques*
Affiliation:
Department of Cardiology I, Santa Maria Hospital – CHLN, Lisbon Academic Medical Centre, CCUL, Lisbon, Portugal Department of Pharmacology and Neurosciences, Lisbon University Medical School, Lisbon, Portugal
Cristina Gonçalves
Affiliation:
Department of Paediatrics, Santa Maria Hospital – CHLN, Lisbon Academic Medical Centre, Lisbon, Portugal
*
Correspondence to: Dr J. Silva Marques, MD, Department of Cardiology I, Santa Maria Hospital – CHLN, Lisbon Academic Medical Centre, CCUL, 1649-035 Lisbon, Portugal. Tel:+351 916060822; Fax:+351 217805617; E-mail: [email protected]
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Abstract

Lower limb ischaemia is the most frequent complication of cardiac catheterisation in children. It is often overlooked, but it can cause significant disability and may limit arterial access sites to repeat diagnostic or interventional catheterisations. A narrative review of the literature on arterial access site thrombosis in children was carried out with a special focus on current evidence that supports preventive and treatment strategies. Anticoagulation, thrombolysis, and thrombectomy have been used successfully to treat arterial access site thrombosis. However, it is not completely established which is the role of each treatment modality and what is the most appropriate timing to deliver it. Therefore, diagnostic and therapeutic strategies have to be prospectively investigated, particularly for clarifying the role of new pharmacologic interventions and of percutaneous and surgical thrombectomy in the current era.

Keywords

Cardiac catheterisationthrombosisanticoagulantsthrombolysisthrombectomy
Type
Review Articles
Information
Cardiology in the Young , Volume 24 , Issue 5 , October 2014 , pp. 767 - 773
Copyright
© Cambridge University Press 2014 

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