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Pathophysiology of paradoxical embolism: evaluation of the role of interatrial septum anatomy based on the intracardiac echocardiography assessment of patients with right-to-left shunting

Published online by Cambridge University Press:  08 October 2013

Gianluca Rigatelli ,
Fabio Dell’Avvocata ,
Dobrin Vassiliev ,
Ramesh Daggubati ,
Ashesh Buch ,
Aravinda Nanjiundappa ,
Massimo Giordan ,
Laura Oliva ,
Dario Adami  and
Paolo Cardaioli
Gianluca Rigatelli*
Affiliation:
Section of Adult Congenital and Adult Heart Disease, Cardiovascular Diagnosis and Endoluminal Interventions, Rovigo General Hospital, Rovigo, Italy
Fabio Dell’Avvocata
Affiliation:
Section of Adult Congenital and Adult Heart Disease, Cardiovascular Diagnosis and Endoluminal Interventions, Rovigo General Hospital, Rovigo, Italy
Dobrin Vassiliev
Affiliation:
Interventional Cardiology, National Heart Institute, Sofia, Bulgaria
Ramesh Daggubati
Affiliation:
Brody School of Medicine at East Carolina University, United States of America
Ashesh Buch
Affiliation:
Brody School of Medicine at East Carolina University, United States of America
Aravinda Nanjiundappa
Affiliation:
CAMC Vascular Center of Excellence, West Virginia University, Charleston, West Virginia, United States of America
Massimo Giordan
Affiliation:
Section of Adult Congenital and Adult Heart Disease, Cardiovascular Diagnosis and Endoluminal Interventions, Rovigo General Hospital, Rovigo, Italy
Laura Oliva
Affiliation:
Section of Adult Congenital and Adult Heart Disease, Cardiovascular Diagnosis and Endoluminal Interventions, Rovigo General Hospital, Rovigo, Italy
Dario Adami
Affiliation:
Section of Adult Congenital and Adult Heart Disease, Cardiovascular Diagnosis and Endoluminal Interventions, Rovigo General Hospital, Rovigo, Italy
Paolo Cardaioli
Affiliation:
Section of Adult Congenital and Adult Heart Disease, Cardiovascular Diagnosis and Endoluminal Interventions, Rovigo General Hospital, Rovigo, Italy
*
Correspondance to: G. Rigatelli, MD, PhD, FACP, FACC, FESC, FSCAI, Via Mozart 9, 37048 Legnago, Verona, Italy. Tel: +3903471912016; Fax: +39044220164; E-mail: [email protected]
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Abstract

Background: Detailed anatomic variants of the interatrial septum in patients with right-to-left shunt and contribution of specific anatomies to the risk of ischaemic recurrences has not yet been comprehensively classified. Objective: To report a classification of the anatomic variants of the interatrial septum as observed by intracardiac echocardiography and its correlation with clinical and functional characteristics. Methods: We retrospectively reviewed the medical and instrumental data of 520 consecutive patients (mean age 44±15. 5 years, 355 women) who had over a 10-year period undergone intracardiac echocardiography and right-to-left shunt catheter-based closure. The four main features used to analyse were: (a) diameter of the oval fossa, (b) presence and length of the channel, (c) presence and degree of atrial septal aneurysm, and (d) rim thickness. The presence of Eustachian valve was also tabulated. Results: The combinations of interatrial septum anatomical features were classified into six main anatomical subgroups. Recurrent embolism, multiple ischaemic foci on brain magnetic resonance imaging, high grade shunt, and permanent shunt before transcatheter closure procedure were associated with type 2, type 4, and type 6. Type 4 anatomical subtype (OR 4.1, 1.5–8 [95% CI], p<0.001) and type 2+presence of Eustachian valve (OR 4.3, 1.6–9 [95% CI], p<0.001) were the strongest predictors of recurrent ischaemic events before transcatheter closure. Conclusion: Our study showed that interatrial septum anatomy greatly differs among patients with right-to-left shunt, as well as the risk of ischaemic recurrences in different anatomies.

Keywords

Patent foramen ovaleechocardiographystrokeanatomy
Type
Original Articles
Information
Cardiology in the Young , Volume 25 , Issue 1 , January 2015 , pp. 47 - 55
Copyright
Copyright © Cambridge University Press 2013 

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