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Obstructing balloon catheter for the induction of systolic hypertension in the pulmonary ventricle—an acute hemodynamic study in the piglet

Published online by Cambridge University Press:  19 August 2008

Robert Krzeski
Affiliation:
From the Departments of Pediatrics, The University of North Carolina, Chapel Hill
Hiroshi Katayama*
Affiliation:
From the Departments of Pediatrics, The University of North Carolina, Chapel Hill
Philipp Bonhoeffer
Affiliation:
Department of Cardiology, Ospedali Riuniti di Bergamo, Bergamo
Carol L. Lucas
Affiliation:
From the Department of Biomedical Engineering, The University of North Carolina, Chapel Hill
Walker A. Long
Affiliation:
From the Departments of Pediatrics, The University of North Carolina, Chapel Hill Department of Cardiology, Wellcome Research Laboratories, Research Triangle Park
Lucio Parenzan
Affiliation:
Department of Cardiology, Ospedali Riuniti di Bergamo, Bergamo
G. William Henry
Affiliation:
From the Departments of Pediatrics, The University of North Carolina, Chapel Hill
*
Dr. Robert Krzeski, Department of Pediatrics, The University of North Carolina, CB 7220, 311 Burnett-Womack 229H, Chapel Hill, NC 27599USA. Tel. 919-966-4601; Fax. 919-966-6892.

Abstract

The use of an obstructing balloon catheter positioned in the outflow tract of the pulmonary ventricle may be an alternative method for the adaptation of the left ventricle to an increased afterload prior to an arterial switch procedure in patients with complete transposition requiring a two-stage approach. We tested this approach in an acute hemodynamic study in a piglet model. Seven piglets were anesthetized with halothane and ventilated at FiO2 1.0. Through a median sternotomy, the great vessels were exposed. The right ventricular pressure and the aortic blood pressure were recorded using microtip manometers, cardiac output was measured by an electromagnetic flow probe on the ascending aorta. A 6F or 7F Berman angiographic catheter was placed in the lumen of the pulmonary artery and the balloon inflated to decrease cardiac output no more than 30%. The hemodynamic changes observed after balloon inflation included an 100% increase in systolic right ventricular pressure (control vs balloon inflation (mean±SE) 20.4 ± 1.5 mm Hg vs 46.6 ± 4 mm Hg, p<0.001), a slight reduction in systolic aortic pressure (75.5 ± 3.8 mm Hg vs 65.0 ± 5.8 mm Hg; p<0.05), and a reduction in cardiac output by 30% (1.1 ± 0.081/min vs 0.8 ±0.08 1/min, p<0.01). The systolic right ventricular to aortic pressure ratio was increased from 0.27 ± 0.02 to 0.69 ± 0.08, p<0.001. This study shows that a balloon catheter may be useful in creating systolic hypertension in the pulmonary ventricle in patients with complete transposition requiring a two-stage approach.

Type
Preliminary Reports
Copyright
Copyright © Cambridge University Press 1992

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