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The neurodevelopmental implications of hypoplastic left heart syndrome in the fetus

Published online by Cambridge University Press:  08 November 2016

David F. A. Lloyd ,
Mary A. Rutherford ,
John M. Simpson  and
Reza Razavi
David F. A. Lloyd*
Affiliation:
Paediatric Cardiology Department, Evelina Children’s Hospital, London, United Kingdom Division of Imaging Sciences and Biomedical Engineering, King’s College London, London, United Kingdom
Mary A. Rutherford
Affiliation:
Division of Imaging Sciences and Biomedical Engineering, King’s College London, London, United Kingdom
John M. Simpson
Affiliation:
Paediatric Cardiology Department, Evelina Children’s Hospital, London, United Kingdom
Reza Razavi
Affiliation:
Paediatric Cardiology Department, Evelina Children’s Hospital, London, United Kingdom Division of Imaging Sciences and Biomedical Engineering, King’s College London, London, United Kingdom
*
Correspondence to: Dr D. F. A. Lloyd, MBChB, MRCPCH, MPhil, Clinical Research Fellow (Paediatric & Fetal Cardiology), Division of Imaging Sciences and Biomedical Engineering, 4th Floor, Lambeth Wing, St. Thomas Hospital, Westminster Bridge Road, London, SE1 7TH, United Kingdom. Tel: +44 20 7188 7188; Fax: +44 20 7188 5442; E-mail: [email protected]
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Abstract

As survival after cardiac surgery continues to improve, an increasing number of patients with hypoplastic left heart syndrome are reaching school age and beyond, with growing recognition of the wide range of neurodevelopmental challenges many survivors face. Improvements in fetal detection rates, coupled with advances in fetal ultrasound and MRI imaging, are contributing to a growing body of evidence that abnormal brain architecture is in fact present before birth in hypoplastic left heart syndrome patients, rather than being solely attributable to postnatal factors. We present an overview of the contemporary data on neurodevelopmental outcomes in hypoplastic left heart syndrome, focussing on imaging techniques that are providing greater insight into the nature of disruptions to the fetal circulation, alterations in cerebral blood flow and substrate delivery, disordered brain development, and an increased potential for neurological injury. These susceptibilities are present before any intervention, and are almost certainly substantial contributors to adverse neurodevelopmental outcomes in later childhood. The task now is to determine which subgroups of patients with hypoplastic left heart syndrome are at particular risk of poor neurodevelopmental outcomes and how that risk might be modified. This will allow for more comprehensive counselling for carers, better-informed decision making before birth, and earlier, more tailored provision of neuroprotective strategies and developmental support in the postnatal period.

Keywords

Fetal cardiologypaediatric cardiologyCHDhypoplastic left heart syndromeneurodevelopment
Type
Review Articles
Information
Cardiology in the Young , Volume 27 , Issue 2 , March 2017 , pp. 217 - 223
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Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© Cambridge University Press 2016

Surgical outcomes for patients with CHD have traditionally been measured in terms of short-term morbidity and mortality. As survival from cardiac surgery continues to improve, robust data are emerging on the prevalence of a wide range of neurodevelopmental impairments in up to half of survivors,Reference Donofrio, Duplessis and Limperopoulos 1 with univentricular conditions such as hypoplastic left heart syndrome among the highest risk.Reference Donofrio, Duplessis and Limperopoulos 1 – Reference Gaynor, Stopp and Wypij 6 Indeed, the burden of impairments in these patients has prompted some groups to suggest that neurodevelopmental outcomes should be one of the primary outcome measures in clinical decision making for patients with CHD.Reference Shillingford, Ittenbach and Marino 7

The potential causative and contributory factors are myriad. Many CHDs require corrective or palliative surgery in the neonatal period, and the use of cardiopulmonary bypass, deep hypothermic circulatory arrest, and various surgical and postoperative factors have all been implicated in contributing to adverse neurodevelopmental outcomes.Reference Sarajuuri, Jokinen and Puosi 3 , Reference Wypij, Newburger and Rappaport 8 – Reference von Rhein, Dimitropoulos, Valsangiacomo Buechel, Landolt and Latal 10 The palliative approach used in univentricular conditions necessitates multiple obligatory surgeries, persistently abnormal haemodynamics, and lifelong cardiovascular morbidity.Reference Kempny, Dimopoulos and Gatzoulis 11 Chromosomal and other syndromic conditions associated with CHD are independently associated with impaired neurodevelopmental status.Reference Ballweg, Wernovsky and Gaynor 12 Other genetic factors, for example, expression of neuroprotective apolipoprotein E, may help modulate brain injury following surgery in certain patients.Reference Laskowitz, Lynch and Warner 13 Socio-economic and parental factors also influence later intellectual development.Reference Forbess, Visconti, Bellinger and Howe 14 , Reference Kucik, Nembhard and Donohue 15 Increasingly, however, both preoperative and prenatal brain dysgenesis, immaturity, and white matter injury are being recognised in patients with CHD.Reference Miller, McQuillen and Hamrick 16 , Reference Owen, Shevell, Majnemer and Limperopoulos 17

In the last few decades, major advances have been made in diagnosing structural heart defects before birth, and anatomical variables that are likely to contribute to poor surgical outcomes are more effectively diagnosed than ever before.Reference Hunter and Simpson 18 The ability to identify fetuses and neonates with pre-intervention brain abnormalities, reduced cerebral blood flow, or other risk factors associated with later neurological impairments may also help identify subgroups of patients at high risk of poor neurodevelopmental outcomes. This could have important consequences for prenatal counselling, which often focusses on fetal risk factors affecting surgical mortality, even though these may in fact have little effect on parental decision making.Reference Rychik, Szwast and Natarajan 19 It may also help identify infants at increased risk in the early neonatal and perioperative period, in whom novel neuroprotective techniques may be of particular benefit.Reference Marino 20

This manuscript reviews existing data regarding neurodevelopmental outcomes in patients with hypoplastic left heart syndrome, with particular attention to factors encountered in the fetus or neonate before surgical intervention that may have a bearing on later brain development.

Hypoplastic left heart syndrome and neurodevelopmental outcomes

Hypoplastic left heart syndrome is a spectrum of congenital cardiac anomalies in which the left-sided heart chambers are small or absent with a hypoplastic ascending aorta and arch. This results in the inability of the left heart to support the systemic circulation in postnatal life.

Norwood et alReference Norwood, Lang, Casteneda and Campbell 21 performed the first successful staged surgical palliation in a group of patients operated on from 1979 to 1981; however, in most centres, it was well over a decade before the procedure was performed in significant numbers. Thus, an increasing number of patients with hypoplastic left heart syndrome are now reaching school age and early adulthood, with consequent recognition of the significant neurodevelopmental challenges many survivors face. Over 30% of infants with hypoplastic left heart syndrome experience moderate to severe neurodevelopmental impairments,Reference Gaynor, Gerdes and Nord 4 including deficits in gross and fine psychomotor development, hypotonia, behavioural problems, microcephaly, and global developmental delay.Reference Majnemer, Limperopoulos, Shevell, Rohlicek, Rosenblatt and Tchervenkov 22 School-aged children often manifest motor deficiencies such as poor balance, coordination, and dexterity; behavioural issues such as shyness or inattention; and significant cognitive challenges.Reference Majnemer, Limperopoulos, Shevell, Rohlicek, Rosenblatt and Tchervenkov 22 Indeed, up to a third of these children will receive some form of special education, with around one in five scoring an intelligence quotient (IQ) of <70.Reference Mahle and Wernovsky 2 A similar picture is emerging from the growing cohort of patients surviving into adulthood.Reference Kempny, Dimopoulos and Gatzoulis 11 Patients with hypoplastic left heart syndrome appear to be significantly more affected than patients with other univentricular conditions in terms of both neurocognitiveReference Sarajuuri, Jokinen and Puosi 3 and educational and behavioural difficulties.Reference Davidson, Gringras, Fairhurst and Simpson 5

Despite recent advances in surgical and bypass techniques used in the treatment of hypoplastic left heart syndrome such as off-bypass neonatal palliation, anterograde regional cerebral perfusion during cardiac arrest, and near-infrared cerebral saturation monitoring,Reference Hirsch, Jacobs and Andropoulos 9 , Reference Hoffman, Brosig, Mussatto, Tweddell and Ghanayem 23 neurodevelopmental outcomes following the Norwood procedure have remained relatively static.Reference Knirsch, Liamlahi and Hug 24 , Reference Newburger, Sleeper and Bellinger 25 As early as the 1990s, however, evidence began to emerge of clinical neurological and electroencephalographic impairments in newborn babies with CHD even before intervention,Reference Limperopoulos, Majnemer, Shevell, Rosenblatt, Rohlicek and Tchervenkov 26 , Reference Limperopoulos, Majnemer, Shevell, Rosenblatt, Rohlicek and Tchervenkov 27 which were strongly linked to later neuromotor and cognitive impairments, functional limitations, and impaired quality of life.Reference Donofrio, Duplessis and Limperopoulos 1 , Reference Limperopoulos, Majnemer, Shevell, Rosenblatt, Rohlicek and Tchervenkov 27 There is now a growing body of evidence that the neurodevelopmental outcomes for hypoplastic left heart syndrome patients are not solely determined by clinical, surgical, and interventional factors after birth; a significant burden of pre-existing brain abnormalities exists even before any attempts at surgical palliation.

Effects of hypoplastic left heart syndrome on fetal circulation

In the normal fetus, both the right and the left sides of the heart support the systemic circulation, atrial and arterial shunts are present, and the placental circulation provides both oxygenation and nutritional support (Fig 1a).Reference Hunter and Simpson 18 Placental blood is preferentially streamed via the foramen ovale to the left heart, which supplies the superior portion of the systemic circulation, delivering oxygen-rich and nutritionally rich blood to the ascending aorta, carotid arteries, and the developing brain.

Figure 1 In the normal fetal circulation (a), oxygenated blood is shunted to the left heart via the foramen ovale (*), allowing nutrient and oxygen rich blood from the placenta to be preferentially directed to the cerebral circulation. In the fetus with HLHS (b) the left sided structures are underdeveloped, leading to reversed flow at the foramen ovale (*) and aortic isthmus (**), which may be severely hypoplastic. This leads to reduced oxygen and substrate delivery to the developing brain.

The effects of abnormal cardiovascular anatomy on the fetal circulation have been considered in detail since the 1970s.Reference Heymann and Rudolph 28 Depending on the nature of the anatomical disturbance, flow rates in the ascending aorta can be increased or decreased, and the preferential shunting of oxygenated blood to the head and neck vessels may be disrupted.

In the case of hypoplastic left heart syndrome, flow through the often profoundly underdeveloped left ventricle is either reduced or absent. The ascending aorta and the aortic arch are also frequently hypoplastic and dependent on retrograde filling via the arterial duct (Fig 1b). In addition, the obligatory intracardiac mixing of oxygenated and deoxygenated blood and loss of venous streaming results in blood reaching the brain having a lower oxygen and nutritional content than in the normal fetal circulation.Reference Rosenthal 29

Effects of hypoplastic left heart syndrome on fetal brain development

Normal fetal brain growth and development is a function of adequate oxygen and substrate delivery, and the fetus has complex mechanisms for autoregulation of cerebrovascular resistance to increase oxygen delivery and meet cerebral energy requirements.Reference Donofrio and Massaro 30

Intrauterine growth restrictionReference Petrossian, Kuehl and Loffredo 31 and particularly microcephalyReference Hinton, Andelfinger and Sekar 32 are associated with hypoplastic left heart syndrome, with the latter potentially reflecting abnormal brain development in utero. In hypoplastic left heart syndrome, the entire cerebral circulation is dependent on the retrograde flow from the arterial duct through the aortic isthmus, with potential restriction to blood flow to the aortic arch and head and neck vessels (Fig 1b).Reference Sakazaki, Masutani and Sugimoto 33 Microcephaly is known to be associated with reduced cerebral blood flow before birth,Reference Donofrio, Bremer and Schieken 34 , Reference Arduini, Rosati and Caforio 35 and has also been independently associated with a diminutive ascending aorta in hypoplastic left heart syndrome patients.Reference Shillingford, Ittenbach and Marino 7 Cerebral autoregulatory mechanisms offer further insight: during periods of hypoxic stress, the normal fetus compensates by reducing cerebrovascular resistance to re-distribute blood flow to the upper body and brain. This mechanism can be identified prenatally by Doppler ultrasound interrogation showing increased diastolic velocities in the cerebral arteries and reduced diastolic velocities in the descending aorta and umbilical artery.Reference Dubiel, Gunnarsson and Gudmundsson 36 Normative indices of resistance and pulsatility have been established, and z-scores are available.Reference Donofrio and Massaro 30 Several studies have shown lower than normal cerebral artery/umbilical artery resistance ratios in patients with hypoplastic left heart syndrome,Reference Szwast, Tian, McCann, Soffer and Rychik 37 , Reference Masoller, Sanz-Cortés and Crispi 38 suggesting activation of brain-sparing mechanisms in an attempt to increase cerebral blood flow. Indeed, the presence of reversed flow across the aortic isthmus may in itself be an important independent factor in triggering this response.Reference Yamamoto, Khoo, Brooks, Savard, Hirose and Hornberger 39 Maintaining the ability to re-distribute blood flow in this manner may be important; in one retrospectively analysed study of the echocardiograms of 134 hypoplastic left heart syndrome and other single-ventricle fetuses, lower fetal cerebrovascular resistance was positively associated with better neurodevelopmental scores in later life.Reference Williams, Fifer, Jaeggi, Levine, Michelfelder and Szwast 40

In addition to microcephaly, both structural brain abnormalities and white matter injury have been identified in patients with hypoplastic left heart syndrome. Neuropathological studies of the brains of fetuses with hypoplastic left heart syndrome have shown structural abnormalities such as agenesis of the corpus callosum and holoprosencephaly,Reference Glauser, Rorke, Weinberg and Clancy 41 as well as significant white matter injuries.Reference Hinton, Andelfinger and Sekar 32 Prenatal and postnatal MRI studies have further defined structural abnormalities, demonstrating incomplete closure of the operculum, ventriculomegaly, and cerebral atrophy. Multiple patterns of brain injury have also been described, including haemorrhagic and thromboembolic infarction, cerebral venous thromboses, periventricular leukomalacia, and grey matter injury.Reference Donofrio, Duplessis and Limperopoulos 1 , Reference Miller, McQuillen and Hamrick 16 , Reference Licht, Shera and Clancy 42 , Reference Block, McQuillen and Chau 43 , Reference Peyvandi, De Santiago and Chakkarapani 44

Although fetal brain injuries detected by MRI have been shown to be strong predictors of neurodevelopmental disability in other high-risk term and preterm newborns,Reference Massaro 45 precisely how preoperative brain injury correlates to later impairment in hypoplastic left heart syndrome patients is not yet clear. In the largest study to date, no direct correlation was found between preoperative brain injury across a range of CHD diagnoses and neurodevelopmental outcomes at 12 months, although over a third of patients either did not survive or failed to return for testing.Reference Andropoulos, Ahmad and Haq 46 Further longitudinal studies are needed, both to provide a uniform means of sub-classifying preoperative brain injuries and to correlate these with later performance across all neurodevelopmental domains.

Advanced fetal MRI techniques have offered further insights into abnormal brain development in hypoplastic left heart syndrome. MRI spin-label perfusion studies have shown significantly reduced cerebral blood flow in the months before surgery.Reference Licht, Wang and Silvestre 47 Magnetic resonance spectroscopy enables in vivo quantification of certain chemical compounds and metabolites. Using this technique, term newborns with single-ventricle hearts were shown to have increased cerebral lactate levels, which may indicate inadequate cerebral metabolism before surgery.Reference Miller, McQuillen and Hamrick 16 In addition, by measuring the levels of N-acetylaspartate, a marker of neuronal integrity, lactate/choline ratios, and average diffusivity measured by diffusion tensor imaging, patients with CHD have been found to have features of delayed brain maturation versus controls of around 1 month, re-asserting that inefficient cerebral substrate delivery is likely to begin before birth.Reference Donofrio and Massaro 30 Indeed, by using similar techniques on the fetal brain, prenatal MRI studies have identified that brain metabolism, growth, and maturation are particularly delayed in the third trimester, a period of increased synapse formation, myelination, and high metabolic demand. A reduction in combined ventricular output across the aortic valve was independently associated with a reduction in total brain volume, and absence of anterograde arch flow was associated with delayed brain maturity.Reference Limperopoulos, Tworetzky and McElhinney 48 In contrast to overt brain injury, markers of brain immaturity appear to correlate more convincingly to later neurodevelopmental status, with severity at birth shown to be a good predictor of neurodevelopmental impairment at 2 years of age after cardiac surgery.Reference Beca, Gunn and Coleman 49 Furthermore, studies in adolescents have also shown a direct correlation between brain volume and neurodevelopmental outcomes.Reference von Rhein, Buchmann and Hagmann 50

Finally, although it has been demonstrated that patients with delayed brain maturation are at particular risk of sustaining new white matter injuries postoperatively,Reference Andropoulos, Hunter and Nelson 51 pre-existing brain injury does not appear to worsen following surgery, adding more weight to the argument that surgical factors may play a lesser role than that previously suspected.Reference Block, McQuillen and Chau 43 , Reference Wernovsky 52

Opportunities for the future

Alongside exciting developments in three and four-dimensional fetal ultrasound such as spatio-temporal image correlation imaging,Reference Ahmed 53 fetal MRI is quickly gaining ground as an important complementary imaging tool, with the additional resources required increasingly offset by a growing number of fetal indicationsReference Gholipour, Estroff and Barnewolt 54 and rapidly developing MRI infrastructure.Reference Svenson and Steele 55 By combining established techniques with advanced motion-correction algorithms,Reference Kainz, Malamateniou and Murgasova 56 retrospectively gated flow measurements,Reference Seed, van Amerom and Yoo 57 and non-invasive estimates of intravascular oxygen saturations,Reference Sun, Macgowan and Sled 58 there is the potential to generate a detailed anatomical and physiological profile of the fetal circulation in CHD.

In addition, centres performing prenatal brain imaging are enhancing our understanding of both gross brain injury and subtle patterns of disordered brain development and oxygen uptake and metabolism, which may accompany these disruptions.Reference Sun, Macgowan and Sled 58 – Reference Rutherford, Biarge, Allsop and Counsell 60 In correlating these data to later neurodevelopmental impairments, it may be possible to establish hypoplastic left heart syndrome cardiac phenotypes, patterns of disordered brain development, and categories of brain injury that confer a higher risk for later neurodevelopmental problems. Addressing modifiable risk factors via tailored neuroprotective strategies,Reference Hirsch, Jacobs and Andropoulos 9 novel monitoring techniques,Reference Hoffman, Brosig, Mussatto, Tweddell and Ghanayem 23 and judicious attention to anaesthetic load,Reference Andropoulos, Ahmad and Haq 46 in conjunction with subsequent early access to developmental support programmes, could help improve longer-term outcomes.Reference Marino 20

Further into the future, as we begin to understand the complex fetoplacental interactions in fetuses with CHD, manipulation of the fetal circulation via experimental interventions such as maternal hyperoxygenation may provide a non-invasive means of improving cerebral oxygen and substrate delivery in selected patients.Reference Porayette, Sun and Jaeggi 61 Finally, the use of direct fetal cardiac intervention, currently being explored by a small number of centres for a limited set of indications,Reference McElhinney, Tworetzky and Lock 62 may develop a role as our understanding and expertise develop in this area.

Impact on fetal counselling

Counselling the prospective parents of a fetus with hypoplastic left heart syndrome poses many challenges for physicians, counsellors, and the parents themselves. Potential management options may include a variety of approaches, including variants of the Norwood procedure, the hybrid procedure, compassionate care after birth, primary transplantation, or termination of the pregnancy. As such, an antenatal diagnosis of hypoplastic left heart syndrome demands tailored, sensitive, and intuitive counselling, relevant to each parent’s level of understanding and cultural, moral, and emotional needs.Reference Allan and Huggon 63 Determining fetal phenotypes at high risk not only of surgical mortality but also of poor neurodevelopmental outcome may allow for more comprehensive counselling for carers, in whom predictions based on mortality risk alone have been shown to have little effect on antenatal decision making.Reference Rychik, Szwast and Natarajan 19 A more comprehensive risk profile that includes neurodevelopmental risk factors may be far more relevant for prospective parents, in terms of both antenatal decision making and longer-term expectations.

Summary

Neonates with hypoplastic left heart syndrome have a unique set of neurological vulnerabilities before they even encounter the operating theatre, with the potential for impaired cerebral blood flow, oxygen and nutrient delivery, leading to delayed or disordered brain development, and pre-existing brain injuries. These factors are present before any intervention, and are almost certainly a substantial contributor to the many factors that may contribute to adverse neurodevelopmental outcomes in later childhood and adulthood.

The use of novel cardiac neuroimaging before and after birth is enhancing our ability to define specific hypoplastic left heart syndrome phenotypes at risk of developing significant neurodevelopmental impairments, potentially providing opportunities to tailor neuroprotective strategies, enable early access to structured neurodevelopmental support programmes, and enhance fetal counselling.

Acknowledgement

Open access for this article was funded by King’s College London.

Financial Support

This research received no specific grant from any funding agency or from commercial or not-for-profit sectors.

Conflicts of Interest

None.

References

1. Donofrio, MT, Duplessis, AJ, Limperopoulos, C. Impact of congenital heart disease on fetal brain development and injury. Curr Opin Pediatr 2011; 23: 502–511.Google Scholar
2. Mahle, WT, Wernovsky, G. Neurodevelopmental outcomes in hypoplastic left heart syndrome. Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2004; 7: 39–47.Google Scholar
3. Sarajuuri, A, Jokinen, E, Puosi, R, et al. Neurodevelopment in children with hypoplastic left heart syndrome. J Pediatr 2010; 157: 414–420; e414.Google Scholar
4. Gaynor, JW, Gerdes, M, Nord, AS, et al. Is cardiac diagnosis a predictor of neurodevelopmental outcome after cardiac surgery in infancy? Cardiol Young 2010; 140: 1230–1237.Google ScholarPubMed
5. Davidson, J, Gringras, P, Fairhurst, C, Simpson, J. Physical and neurodevelopmental outcomes in children with single-ventricle circulation. Arch Dis Child 2015; 100: 449–453.Google Scholar
6. Gaynor, JW, Stopp, C, Wypij, D, et al. Neurodevelopmental outcomes after cardiac surgery in infancy. Pediatrics 2015; 135: 816–825.Google Scholar
7. Shillingford, AJ, Ittenbach, RF, Marino, BS, et al. Aortic morphometry and microcephaly in hypoplastic left heart syndrome. Cardiol Young 2007; 17: 189–195.CrossRefGoogle ScholarPubMed
8. Wypij, D, Newburger, JW, Rappaport, LA. The effect of duration of deep hypothermic circulatory arrest in infant heart surgery on late neurodevelopment: the Boston Circulatory Arrest Trial. J Thorac Cardiovasc Surg 2003; 126: 1397–1403.Google Scholar
9. Hirsch, JC, Jacobs, ML, Andropoulos, D, et al. Protecting the infant brain during cardiac surgery: a systematic review. Ann Thorac Surg 2012; 94: 1365–1373.Google Scholar
10. von Rhein, M, Dimitropoulos, A, Valsangiacomo Buechel, ER, Landolt, MA, Latal, B. Risk factors for neurodevelopmental impairments in school-age children after cardiac surgery with full-flow cardiopulmonary bypass. J Thorac Cardiovasc Surg 2012; 144: 577–583.Google Scholar
11. Kempny, A, Dimopoulos, K, Gatzoulis, MA. Single-ventricle physiology in the UK: an ongoing challenge of growing numbers and of growing complexity of congenital heart disease. Heart 2014; 100: 1315–1316.CrossRefGoogle ScholarPubMed
12. Ballweg, JA, Wernovsky, G, Gaynor, JW. Neurodevelopmental outcomes following congenital heart surgery. Pediatr Cardiol 2007; 28: 126–133.Google Scholar
13. Laskowitz, DT, Lynch, JR, Warner, DS. Apolipoprotein E modulates the CNS response to injury. J Neurochem 2002; 81 (Suppl 1): 31.Google Scholar
14. Forbess, JM, Visconti, KJ, Bellinger, DC, Howe, RJ. Neurodevelopmental outcomes after biventricular repair of congenital heart defects. J Thorac Cardiovasc Surg 2002; 123: 631–639.Google Scholar
15. Kucik, JE, Nembhard, WN, Donohue, P, et al. Community socioeconomic disadvantage and the survival of infants with congenital heart defects. Am J Public Health 2014; 104: e150–e157.Google Scholar
16. Miller, SP, McQuillen, PS, Hamrick, S, et al. Abnormal brain development in newborns with congenital heart disease. N Engl J Med 2007; 357: 1928–1938.Google Scholar
17. Owen, M, Shevell, M, Majnemer, A, Limperopoulos, C. Abnormal brain structure and function in newborns with complex congenital heart defects before open heart surgery: a review of the evidence. J Child Neurol 2011; 26: 743–755.Google Scholar
18. Hunter, LE, Simpson, JM. Prenatal screening for structural congenital heart disease. Nat Rev Cardiol 2014; 11: 323–334.Google Scholar
19. Rychik, J, Szwast, A, Natarajan, S, et al. Perinatal and early surgical outcome for the fetus with hypoplastic left heart syndrome: a 5-year single institutional experience. Ultrasound Obstet Gynecol 2010; 36: 465–470.Google Scholar
20. Marino, BS. New concepts in predicting, evaluating, and managing neurodevelopmental outcomes in children with congenital heart disease. Curr Opin Pediatr 2013; 25: 574–584.CrossRefGoogle ScholarPubMed
21. Norwood, WI, Lang, P, Casteneda, AR, Campbell, DN. Experience with operations for hypoplastic left heart syndrome. J Thorac Cardiovasc Surg 1981; 82: 511–519.Google Scholar
22. Majnemer, A, Limperopoulos, C, Shevell, MI, Rohlicek, C, Rosenblatt, B, Tchervenkov, C. A new look at outcomes of infants with congenital heart disease. Pediatr Neurol 2009; 40: 197–204.Google Scholar
23. Hoffman, GM, Brosig, CL, Mussatto, KA, Tweddell, JS, Ghanayem, NS. Perioperative cerebral oxygen saturation in neonates with hypoplastic left heart syndrome and childhood neurodevelopmental outcome. J Thorac Cardiovasc Surg 2013; 146: 1153–1164.Google Scholar
24. Knirsch, W, Liamlahi, R, Hug, MI, et al. Mortality and neurodevelopmental outcome at 1 year of age comparing hybrid and Norwood procedures. Eur J Cardiothorac Surg 2012; 42: 33–39.Google Scholar
25. Newburger, JW, Sleeper, LA, Bellinger, DC, et al. Early developmental outcome in children with hypoplastic left heart syndrome and related anomalies: the single ventricle reconstruction trial. Circulation 2012; 125: 2081–2091.Google Scholar
26. Limperopoulos, C, Majnemer, A, Shevell, MI, Rosenblatt, B, Rohlicek, C, Tchervenkov, C. Neurologic status of newborns with congenital heart defects before open heart surgery. Pediatrics 1999; 103: 402–408.Google Scholar
27. Limperopoulos, C, Majnemer, A, Shevell, MI, Rosenblatt, B, Rohlicek, C, Tchervenkov, C. Neurodevelopmental status of newborns and infants with congenital heart defects before and after open heart surgery. J Pediatr 2000; 137: 638–645.Google Scholar
28. Heymann, MA, Rudolph, AM. Effects of congenital heart disease on fetal and neonatal circulations. Prog Cardiovasc Dis 1972; 15: 115–143.Google Scholar
29. Rosenthal, GL. Patterns of prenatal growth among infants with cardiovascular malformations: possible fetal hemodynamic effects. Am J Epidemiol 1996; 143: 505–513.Google Scholar
30. Donofrio, MT, Massaro, AN. Impact of congenital heart disease on brain development and neurodevelopmental outcome. Int J Pediatr 2010; 2010: 359390.CrossRefGoogle ScholarPubMed
31. Petrossian, RA, Kuehl, KS, Loffredo, CA. Relationship of birth weight with congenital cardiovascular malformations in a population-based study. Cardiol Young 2015; 25: 1086–1092.Google Scholar
32. Hinton, RB, Andelfinger, G, Sekar, P, et al. Prenatal head growth and white matter injury in hypoplastic left heart syndrome. Pediatr Res 2008; 64: 364–369.Google Scholar
33. Sakazaki, S, Masutani, S, Sugimoto, M, et al. Oxygen supply to the fetal cerebral circulation in hypoplastic left heart syndrome: a simulation study based on the theoretical models of fetal circulation. Pediatr Cardiol 2014; 36: 677–684.Google Scholar
34. Donofrio, MT, Bremer, YA, Schieken, RM, et al. Autoregulation of cerebral blood flow in fetuses with congenital heart disease: the brain sparing effect. Pediatr Cardiol 2003; 24: 436–443.Google Scholar
35. Arduini, M, Rosati, P, Caforio, L, et al. Cerebral blood flow autoregulation and congenital heart disease: possible causes of abnormal prenatal neurologic development. J Matern Fetal Neonatal Med 2011; 24: 1208–1211.Google Scholar
36. Dubiel, M, Gunnarsson, GO, Gudmundsson, S. Blood redistribution in the fetal brain during chronic hypoxia. Ultrasound Obstet Gynecol 2002; 20: 117–121.Google Scholar
37. Szwast, A, Tian, Z, McCann, M, Soffer, D, Rychik, J. Comparative analysis of cerebrovascular resistance in fetuses with single-ventricle congenital heart disease. Ultrasound Obstet Gynecol 2012; 40: 62–67.CrossRefGoogle ScholarPubMed
38. Masoller, N, Sanz-Cortés, M, Crispi, F, et al. Mid-gestation brain Doppler and head biometry in fetuses with congenital heart disease predict abnormal brain development at birth. Ultrasound Obstet Gynecol 2016; 47: 65–73.Google Scholar
39. Yamamoto, Y, Khoo, NS, Brooks, PA, Savard, W, Hirose, A, Hornberger, LK. Severe left heart obstruction with retrograde arch flow influences fetal cerebral and placental blood flow. Ultrasound Obstet Gynecol 2013; 42: 294–299.Google Scholar
40. Williams, IA, Fifer, C, Jaeggi, E, Levine, JC, Michelfelder, EC, Szwast, AL. The association of fetal cerebrovascular resistance with early neurodevelopment in single ventricle congenital heart disease. Am Heart J 2013; 165: 544–550; e541.CrossRefGoogle ScholarPubMed
41. Glauser, TA, Rorke, LB, Weinberg, PM, Clancy, RR. Congenital brain anomalies associated with the hypoplastic left heart syndrome. Pediatrics 1990; 85: 984–990.Google Scholar
42. Licht, DJ, Shera, DM, Clancy, RR, et al. Brain maturation is delayed in infants with complex congenital heart defects. J Thorac Cardiovasc Surg 2009; 137: 529–536; discussion 536–537.CrossRefGoogle ScholarPubMed
43. Block, AJ, McQuillen, PS, Chau, V, et al. Clinically silent preoperative brain injuries do not worsen with surgery in neonates with congenital heart disease. J Thorac Cardiovasc Surg 2010; 140: 550–557.Google Scholar
44. Peyvandi, S, De Santiago, V, Chakkarapani, E, et al. Association of prenatal diagnosis of critical congenital heart disease with postnatal brain development and the risk of brain injury. JAMA Pediatr 2016; 170: e154450.Google Scholar
45. Massaro, AN. MRI for neurodevelopmental prognostication in the high-risk term infant. Semin Perinatol 2015; 39: 159–167.Google Scholar
46. Andropoulos, DB, Ahmad, HB, Haq, T, et al. The association between brain injury, perioperative anesthetic exposure, and 12-month neurodevelopmental outcomes after neonatal cardiac surgery: a retrospective cohort study. Paediatr Anaesth 2014; 24: 266–274.Google Scholar
47. Licht, DJ, Wang, J, Silvestre, DW, et al. Preoperative cerebral blood flow is diminished in neonates with severe congenital heart defects. J Thorac Cardiovasc Surg 2004; 128: 841–849.Google Scholar
48. Limperopoulos, C, Tworetzky, W, McElhinney, DB, et al. Brain volume and metabolism in fetuses with congenital heart disease: evaluation with quantitative magnetic resonance imaging and spectroscopy. Circulation 2010; 121: 26–33.Google Scholar
49. Beca, J, Gunn, JK, Coleman, L, et al. New white matter brain injury after infant heart surgery is associated with diagnostic group and the use of circulatory arrest. Circulation 2013; 127: 971–979.Google Scholar
50. von Rhein, M, Buchmann, A, Hagmann, C, et al. Brain volumes predict neurodevelopment in adolescents after surgery for congenital heart disease. Brain 2014; 137 (Pt 1): 268–276.CrossRefGoogle ScholarPubMed
51. Andropoulos, DB, Hunter, JV, Nelson, DP, et al. Brain immaturity is associated with brain injury before and after neonatal cardiac surgery with high-flow bypass and cerebral oxygenation monitoring. J Thorac Cardiovasc Surg 2010; 139: 543–556.Google Scholar
52. Wernovsky, G. Current insights regarding neurological and developmental abnormalities in children and young adults with complex congenital cardiac disease. Cardiol Young 2006; 16 (Suppl 1): 92–104.Google Scholar
53. Ahmed, BI. The new 3D/4D based spatio-temporal imaging correlation (STIC) in fetal echocardiography: a promising tool for the future. J Matern Fetal Neonatal Med 2014; 27: 1163–1168.Google Scholar
54. Gholipour, A, Estroff, JA, Barnewolt, CE, et al. Fetal MRI: a technical update with educational aspirations. Concepts Magn Reson Part A Bridg Educ Res 2014; 43: 237–266.Google Scholar
55. Svenson, M, Steele, P. NHS imaging and radiodiagnostic activity, 2013–2014. Retrieved March 12, 2016, from england.nhs.uk/statistics/statistical-work-areas/diagnostics-waiting-times-and-activity/imaging-and-radiodiagnostics-annual-data/ Google Scholar
56. Kainz, B, Malamateniou, C, Murgasova, M, et al. Motion corrected 3D reconstruction of the fetal thorax from prenatal MRI. Med Image Comput Comput Assist Interv 2014; 17 (Pt 2): 284–291.Google Scholar
57. Seed, M, van Amerom, JFP, Yoo, SJ, et al. Feasibility of quantification of the distribution of blood flow in the normal human fetal circulation using CMR: a cross-sectional study. J Cardiovasc Magn Reson 2012; 14: 79.Google Scholar
58. Sun, L, Macgowan, CK, Sled, JG, et al. Reduced fetal cerebral oxygen consumption is associated with smaller brain size in fetuses with congenital heart disease. Circulation 2015; 131: 1313–1323.Google Scholar
59. Rutherford, M, Ramenghi, LA, Edwards, AD, et al. Assessment of brain tissue injury after moderate hypothermia in neonates with hypoxic–ischaemic encephalopathy: a nested substudy of a randomised controlled trial. Lancet Neurol 2010; 9: 39–45.Google Scholar
60. Rutherford, M, Biarge, MM, Allsop, J, Counsell, S. MRI of perinatal brain injury. Pediatr Radiol 2010; 40: 819–833.Google Scholar
61. Porayette, P, Sun, L, Jaeggi, E, et al. MRI reveals hemodynamic changes with acute maternal hyperoxygenation in human fetuses with and without congenital heart disease. J Cardiovasc Magn Reson 2015; 17 (Suppl 1): O55.Google Scholar
62. McElhinney, DB, Tworetzky, W, Lock, JE. Current status of fetal cardiac intervention. Circulation 2010; 121: 1256–1263.Google Scholar
63. Allan, LD, Huggon, IC. Counselling following a diagnosis of congenital heart disease. Prenat Diagn 2004; 24: 1136–1142.Google Scholar
Figure 0

Figure 1 In the normal fetal circulation (a), oxygenated blood is shunted to the left heart via the foramen ovale (*), allowing nutrient and oxygen rich blood from the placenta to be preferentially directed to the cerebral circulation. In the fetus with HLHS (b) the left sided structures are underdeveloped, leading to reversed flow at the foramen ovale (*) and aortic isthmus (**), which may be severely hypoplastic. This leads to reduced oxygen and substrate delivery to the developing brain.