Hostname: page-component-586b7cd67f-vdxz6 Total loading time: 0 Render date: 2024-11-26T22:59:17.737Z Has data issue: false hasContentIssue false
  • English
  • Français

Mitral valvar prolapse is significantly associated with low body mass index in addition to mitral and tricuspid regurgitation

Published online by Cambridge University Press:  12 February 2007

Mohammad-Reza Movahed  and
Absalom D. Hepner
Mohammad-Reza Movahed
Affiliation:
University of Arizona Sarver Heart Center, Tucson, Arizona, United States of America
Absalom D. Hepner
Affiliation:
Department of Medicine, Division of Cardiology, University of California, Irvine Medical Center, Orange, California, United States of America
Get access Rights & Permissions [Opens in a new window]

Abstract

Introduction: An association between mitral valvar prolapse and low body mass index has been proposed. The goal of this study was to evaluate this suggested association using two independent and large databases. For comparison, we evaluated the association, if any, between bicuspid aortic valve and low body mass index. Methods: We retrospectively analyzed, using uni- and multivariate analysis, 1742 echocardiograms that were performed as a part of a cardiac screening of teenage athletes and 24,265 echocardiograms performed between 1984 and 1998 for various clinical indications. Results: The first database included a total of 12,926 (53%) female and 11,339 (47%) male patients. The second database included a total of 1172 male (67%) and 570 female (33%) high school athletes. Mitral valvar prolapse was independently associated with low body mass index in addition to mitral regurgitation in both data bases. An index less than 30 occurred in 78 of 13,874 (0.6%) as opposed to 7 of 3236 (0.2%) in the echo data base, p equal to 0.03, odds ratio: 2.4 confidence intervals: 1.1–5.2, and an index less than 20 occurred in 7 of 354 (2%) as opposed to 6 of 944 (0.6%) in the athletic data base, p equal to 0.03, odds ratio: 3.2 confidence intervals: 1.05–9.5. The finding of a bicuspid aortic valve did not have any association with low body mass index. Conclusion: In our two independent databases, mitral valvar prolapse was independently associated with low body mass index in addition to mitral and tricuspid regurgitaton. The cause of this association remains unknown.

Keywords

Congenital cardiac diseasevalvar regurgitationechocardiographyathletesbody habit
Type
Original Article
Information
Cardiology in the Young , Volume 17 , Issue 2 , April 2007 , pp. 172 - 174
Copyright
© 2007 Cambridge University Press

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Flack JM, Kvasnicka JH, Gardin JM, Gidding SS, Manolio TA, Jacobs Jr. DR Anthropometric and physiologic correlates of mitral valve prolapse in a biethnic cohort of young adults: the CARDIA study. Am Heart J 1999; 138: 486–492.Google Scholar
Freed LA, Levy D, Levine RA, et al. Prevalence and clinical outcome of mitral-valve prolapse. N Engl J Med 1999; 341: 1–7.Google Scholar
Devereux RB, Jones EC, Roman MJ, et al. Prevalence and correlates of mitral valve prolapse in a population-based sample of American Indians: the Strong Heart Study. Am J Med 2001; 111: 679–685.Google Scholar
Savage DD, Garrison RJ, Devereux RB, et al. M. Mitral valve prolapse in the general population. 1. Epidemiologic features: the Framingham Study. Am Heart J 1983; 106: 571–576.Google Scholar
Froom P, Kriwisky M, Ribak J, Sshochat I, Tamir A, Lewis BS. Mitral leaflet motion: age and implications for the diagnosis of mitral valve prolapse. Clin Cardiol 1989; 12: 521–524.Google Scholar
Rosenberg CA, Derman GH, Grabb WC, Buda AJ. Hypomastia and mitral-valve prolapse. Evidence of a linked embryologic and mesenchymal dysplasia. N Engl J Med 1983; 309: 1230–1232.Google Scholar
Devereux RB, Kramer-Fox R, Kligfield P. Mitral valve prolapse: causes, clinical manifestations, and management. Ann Intern Med 1989; 111: 305–317.Google Scholar
Devereux RB, Kramer-Fox R, Brown WT, et al. Relation between clinical features of the mitral prolapse syndrome and echocardiographically documented mitral valve prolapse. J Am Coll Cardiol 1986; 8: 763–772.Google Scholar
Singh RG, Cappucci R, Kramer-Fox R, et al. Severe mitral regurgitation due to mitral valve prolapse: risk factors for development, progression, and need for mitral valve surgery. Am J Cardiol 2000; 85: 193–198.Google Scholar
Waller BF, Morrow AG, Maron BJ, et al. Etiology of clinically isolated, severe, chronic, pure mitral regurgitation: analysis of 97 patients over 30 years of age having mitral valve replacement. Am Heart J 1982; 104: 276–288.Google Scholar
Avierinos JF, Gersh BJ, Melton 3rd LJ, Bailey KR, Shub C, Nishimura RA, Tajik AJ, Enriquez-Sarano M. Natural history of asymptomatic mitral valve prolapse in the community. Circulation 2002; 106: 1355–1361.Google Scholar
Namiki A, Hirai H, Machii K, et al. Tricuspid regurgitation in mitral valve prolapse studied by two-dimensional color flow mapping. J Cardiol 1988; 18: 731–738.Google Scholar
Come PC, Riley MF, Carl LV, Nakao S. Pulsed Doppler echocardiographic evaluation of valvular regurgitation in patients with mitral valve prolapse: comparison with normal subjects. J Am Coll Cardiol 1986; 8: 1355–1364.Google Scholar