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Left and right ventricular function by echocardiography, tissue Doppler imaging, carotid intima-media thickness, and asymmetric dimethyl arginine levels in obese adolescents with metabolic syndrome

Published online by Cambridge University Press:  28 January 2019

Eyup Aslan ,
Ahmet Sert ,
Muammer Buyukinan ,
Mustafa Ozgur Pirgon ,
Huseyin Kurku ,
Hakan Yilmaz  and
Dursun Odabas
Eyup Aslan*
Affiliation:
Department of Pediatric Cardiology, Denizli State Hospital, Denizli, Turkey
Ahmet Sert
Affiliation:
Department of Pediatric Cardiology, Faculty of Medicine, Selcuk University, Konya, Turkey
Muammer Buyukinan
Affiliation:
Department of Pediatric Endocrinology and Diabetes, University of Health Sciences, Konya Training and Research Hospital, Konya, Turkey
Mustafa Ozgur Pirgon
Affiliation:
Department of Pediatric Endocrinology and Diabetes, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey
Huseyin Kurku
Affiliation:
Department of Biochemistry, University of Health Sciences, Konya Training and Research Hospital, Konya, Turkey
Hakan Yilmaz
Affiliation:
Department of Radiology, Agri State Hospital, Agri, Turkey
Dursun Odabas
Affiliation:
Department of Pediatric Cardiology, Faculty of Medicine, Necmettin Erbakan University Konya, Konya, Turkey
*
Author for correspondence: E. Aslan, Department of Pediatric Cardiology, Denizli State Hospital, Denizli, Turkey. Tel: +902582639311; Fax: +902582619206; E-mail: [email protected]
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Abstract

Purpose

The aim of our study was to assess left ventricle and right ventricle systolic and diastolic functions in obese adolescents with metabolic syndrome using conventional echocardiography and pulsed-wave tissue Doppler imaging and to investigate carotis intima-media thickness, and asymmetric dimethyl arginine levels.

Methods

A total of 198 obese adolescents were enrolled in the study. The obese patients were divided into metabolic syndrome group and non-metabolic syndrome group. All subjects underwent laboratory blood tests, including asymmetric dimethyl arginine, complete two-dimensional, pulsed, and tissue Doppler echocardiography, and measurement of the carotid intima-media thickness.

Results

Obese adolescents were characterised by enlarged left end-diastolic, end-systolic and left atrial diameters, thicker left and right ventricular walls compared with non-obese adolescents. The metabolic syndrome group had normal left ventricle systolic function, impaired diastolic function, and altered global systolic and diastolic myocardial performance. In the metabolic syndrome obese group patients, left ventricle mass was found positively correlated with body mass index, waist and hip circumferences, diastolic blood pressure, age, and waist-to-hip circumference ratio. The carotid intima-media thickness was found positively correlated with waist and hip circumferences and total cholesterol levels. Asymmetric dimethyl arginine levels were found positively correlated with systolic blood pressure, waist-to-hip circumference ratio, and diastolic blood pressure.

Conclusions

The results of this study demonstrate that metabolic syndrome in adolescence is associated with significant changes in myocardial geometry and function. In addition, it has been associated with a high level of asymmetric dimethyl arginine concentration and thicker carotid intima-media thickness reflecting endothelial dysfunction.

Keywords

Adolescentasymmetric dimethyl argininecardiovascular diseasecarotid intima-media thicknessmetabolic syndrome
Type
Original Article
Information
Cardiology in the Young , Volume 29 , Issue 3 , March 2019 , pp. 310 - 318
Copyright
© Cambridge University Press 2019 

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Footnotes

Cite this article: Aslan E, Sert A, Buyukinan M, Pirgon MO, Kurku H, Yilmaz H, Odabas D (2019) Left and right ventricular function by echocardiography, tissue Doppler imaging, carotid intima-media thickness, and asymmetric dimethyl arginine levels in obese adolescents with metabolic syndrome. Cardiology in the Young29: 310–318. doi: 10.1017/S1047951118002329

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