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Is there a possible role for haemostasis in the development of perigraft reaction complicating the modified Blalock Taussig shunt?

Published online by Cambridge University Press:  19 August 2008

Ulrike Salzer-Muhar*
Affiliation:
Department of Pediatric Cardiology, General Hospital Vienna, University of Vienna, Austria
Ingrid Pabinger-Fasching
Affiliation:
Department of Haematology and Haemostaseology, General Hospital Vienna, University of Vienna, Austria
Sophie Zacherl-Wightman
Affiliation:
Department of Pediatric Cardiology, General Hospital Vienna, University of Vienna, Austria
*
Ulrike Salzer-Muhar MD, Abteilung für Pediatrische Kardiologie, Univ.-Kinderklinik Wien, Waehringer Guertel 18–20, A–1090 Vienna, Austria. Tel. +43 140 400/3217; Fax +43 140 400/3417; E-mail: [email protected]

Abstract

The perigraft reaction is an unusual complication found in patients in whom a modified Blalock Taussig shunt has been created using a polytetrafluoroethylene graft. We found that, in two infants, consistent laboratory findings during such a perigraft reaction were hypofibrinogenemia, increased levels of thrombin-antithrombin III complex, prothrombinfragment 1 and 2 and products of degradation of fibrin. Normalization of the levels of fibrinogen produced resolution of the perigraft reaction.

Type
Brief Reports
Copyright
Copyright © Cambridge University Press 2000

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