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Iloprost in persistent pulmonary hypertension of the newborn

Published online by Cambridge University Press:  24 May 2005

Michael Ehlen  and
Beatrix Wiebe
Michael Ehlen
Affiliation:
Department of Neonatology and Pediatric Intensive Care, Kinderklinik St. Augustin, St. Augustin, Germany
Beatrix Wiebe
Affiliation:
Department of Neonatology and Pediatric Intensive Care, Kinderklinik St. Augustin, St. Augustin, Germany
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Abstract

Aerosolized iloprost is now used as a therapeutic option in the treatment of pulmonary hypertension. We report on the administration of this derivative of prostacycline in treating severe pulmonary hypertension of the newborn. The combination of iloprost instilled endotracheally and inhaled was chosen as a last attempt at treatment in a critically ill patient who did not respond to advanced conventional treatments, including high frequency oscillation and inhalation of nitric oxide. The use of iloprost converted permanently the right-to-left shunting, leading to a substantial improvement in oxygenation.

Keywords

Prostacyclineinhaled therapyright-to-left shunting
Type
Brief Report
Information
Cardiology in the Young , Volume 13 , Issue 4 , August 2003 , pp. 361 - 363
Copyright
© 2003 Cambridge University Press

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