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Family history of premature coronary heart disease, child cardio-metabolic risk factors and left ventricular mass

Published online by Cambridge University Press:  10 October 2013

Costan G. Magnussen ,
Terence Dwyer  and
Alison Venn
Costan G. Magnussen*
Affiliation:
Menzies Research Institute Tasmania, University of Tasmania, Hobart, Australia Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
Terence Dwyer
Affiliation:
Murdoch Childrens Research Institute, Melbourne, Australia
Alison Venn
Affiliation:
Menzies Research Institute Tasmania, University of Tasmania, Hobart, Australia
*
Correspondence to: Dr C. G. Magnussen, Menzies Research Institute Tasmania, University of Tasmania, MS2 17 Liverpool St, Hobart 7000, Tasmania, Australia. Tel: +61 3 6226 7762; Fax: +61 3 6226 7704; E-mail: [email protected]
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Abstract

In a prospective cohort of 181 individuals followed up since childhood – when aged 9, 12 and 15 years – patients with a family history of premature coronary heart disease (n=18) had higher left ventricular mass index in adulthood – at mean age of 31 years – compared with those without (mean±standard error 39.1±1.9 versus 34.6±0.7 g/m2.7, p=0.04). The correlation between adult left ventricular mass index and child triglycerides (r=0.66, p=0.04 versus r=−0.03, p=0.75; pdiff=0.02) and diastolic blood pressure (r=0.65, p=0.02 versus r=0.16, p=0.07; pdiff=0.05) was stronger among those with a family history of coronary heart disease than in those without. Although preliminary, these data suggest that the higher left ventricular mass index among adults with a family history might be explained by their increased susceptibility to child cardio-metabolic risk factors.

Keywords

Family historyrisk factorsleft ventricular masspaediatrics
Type
Brief Reports
Information
Cardiology in the Young , Volume 24 , Issue 5 , October 2014 , pp. 938 - 940
Copyright
Copyright © Cambridge University Press 2013 

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References

1. Juonala, M, Viikari, JS, Räsänen, L, Helenius, H, Pietikainen, M, Raitakari, OT. Young adults with family history of coronary heart disease have increased arterial vulnerability to metabolic risk factors: the Cardiovascular Risk in Young Finns Study. Arterioscler Thromb Vasc Biol 2006; 26: 1376–1382.CrossRefGoogle ScholarPubMed
2. Mancia, G, Bombelli, M, Facchetti, R, et al. Long-term risk of diabetes, hypertension and left ventricular hypertrophy associated with the metabolic syndrome in a general population. J Hypertens 2008; 26: 1602–1611.Google Scholar
3. Li, X, Li, S, Ulusoy, E, Chen, W, Srinivasan, SR, Berenson, GS. Childhood adiposity as a predictor of cardiac mass in adulthood: the Bogalusa Heart Study. Circulation 2004; 110: 3488–3492.Google Scholar
4. Sivanandam, S, Sinaiko, AR, Jacobs, DR Jr., Steffen, L, Moran, A, Steinberger, J. Relation of increase in adiposity to increase in left ventricular mass from childhood to young adulthood. Am J Cardiol 2006; 98: 411–415.Google Scholar
5. Magnussen, CG, Thomson, R, Cleland, VJ, Ukoumunne, OC, Dwyer, T, Venn, A. Factors affecting the stability of blood lipid and lipoprotein levels from youth to adulthood: evidence from the Childhood Determinants of Adult Health Study. Arch Pediatr Adolesc Med 2011; 165: 68–76.Google Scholar
6. Mitchell, BD, Kammerer, CM, Blangero, J, et al. Genetic and environmental contributions to cardiovascular risk factors in Mexican Americans. The San Antonio Family Heart Study. Circulation 1996; 94: 2159–2170.Google Scholar
7. Kankaanpaa, M, Lehto, HR, Parkka, JP, et al. Myocardial triglyceride content and epicardial fat mass in human obesity: relationship to left ventricular function and serum free fatty acid levels. J Clin Endocrinol Metab 2006; 91: 4689–4695.Google Scholar
8. Di Bonito, P, Moio, N, Scilla, C, et al. Usefulness of the high triglyceride-to-HDL cholesterol ratio to identify cardiometabolic risk factors and preclinical signs of organ damage in outpatient children. Diabetes Care 2012; 35: 158–162.Google Scholar
9. Koskinen, J, Magnussen, CG, Kahonen, M, et al. Association of liver enzymes with metabolic syndrome and carotid atherosclerosis in young adults. The Cardiovascular Risk in Young Finns Study. Ann Med 2012; 44: 187–195.CrossRefGoogle ScholarPubMed