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Exercise-induced cardiac fatigue in low and normal birth weight young black adults

Published online by Cambridge University Press:  09 April 2014

Jephat Chifamba Open the ORCID record for Jephat Chifamba [Opens in a new window] ,
Chidochashe Mapfumo ,
Dorcas W. Mawoneke ,
Lenon T. Gwaunza ,
Larry A. Allen  and
Herbert M. Chinyanga
Jephat Chifamba*
Affiliation:
Department of Physiology, University of Zimbabwe, College of Health Sciences, Mount Pleasant, Harare, Zimbabwe
Chidochashe Mapfumo
Affiliation:
Department of Physiology, University of Zimbabwe, College of Health Sciences, Mount Pleasant, Harare, Zimbabwe
Dorcas W. Mawoneke
Affiliation:
Department of Radiology, Parirenyatwa Group of Hospitals, Avondale, Harare, Zimbabwe
Lenon T. Gwaunza
Affiliation:
Department of Physiology, University of Zimbabwe, College of Health Sciences, Mount Pleasant, Harare, Zimbabwe
Larry A. Allen
Affiliation:
Section of Advanced Heart Failure and Transplant, University of Colorado School of Medicine, Aurora, United States of America
Herbert M. Chinyanga
Affiliation:
Department of Physiology, University of Zimbabwe, College of Health Sciences, Mount Pleasant, Harare, Zimbabwe
*
Correspondence to: J. Chifamba (MPhil), Department of Physiology, University of Zimbabwe, College of Health Sciences, Harare MP167, Zimbabwe. Tel: +263 4303211, ext 17100; Fax: +263 4333678; E-mail: [email protected]
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Abstract

The objective of the study was to compare the change in diastolic function, E/A ratio, in response to prolonged exercise in low birth weight and normal birth weight individuals. Using a case–control study design, 23 students of the University of Zimbabwe College of Health Sciences who had neonatal clinic cards as proof of birth weight were recruited into the study. Measurements of diastolic function, E/A ratio, were obtained using an echocardiogram before and after 75 minutes of exercise. Among the cohort, seven had low birth weight – <2500 g, three female patients and four male patients – and 16 had normal birth weight – six female patients and 10 male patients). The mean age was 20.7±3.3 years. After prolonged exercise for 75 minutes of running on a treadmill, decreases in diastolic function, E/A ratio, were significantly greater in low birth weight than in normal birth weight individuals (0.48±0.27 versus 0.19±0.18 p<0.05, respectively). There was a significant association between low birth weight and exercise-induced cardiac fatigue (the χ2 test p<0.05, odds ratio 4.64, 95% confidence interval 1.19–18.1). We conclude that low birth weight is associated with exercise-induced diastolic dysfunction in young adults.

Keywords

Low birth weightexercise-induced cardiac fatiguediastolic function
Type
Original Articles
Information
Cardiology in the Young , Volume 25 , Issue 3 , March 2015 , pp. 481 - 484
Copyright
© Cambridge University Press 2014 

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References

1. Carlsson, S, Persson, P, Alvarsson, M, et al. Low birth weight, family history of diabetes, and glucose intolerance in Swedish middle-aged men. Diabetes Care 1999; 22: 1043–1047.Google Scholar
2. Longo-Mbenza, B, Vangu Ngoma, D, Mbungu Fuele, S. Low birth weight, metabolic syndrome and their associations with the global crisis of 1930–1945, rapidly growing economy and coronary heart disease in Central Africa. Int J Nutr Metab 2010; 2: 1–10.Google Scholar
3. United Nations Children’s Fund and World Health Organization. Low Birth Weight: Country, Regional and Global Estimates. UNICEF, New York, 2006.Google Scholar
4. Kent, T, Sonnet, J, Perrie, O, Natasha, C, Job, F, George, G. Regulation of cardiomyocyte population in the developing heart. Prog Biophysiol Mol 2011; 106 289–299.Google Scholar
5. Barker, DJ, Osmond, C. Low birth weight and hypertension. BMJ 1988; 297: 134–135.CrossRefGoogle ScholarPubMed
6. Barker, DJ, Osmond, C, Golding, J, Kuh, D, Wadsworth, ME. Growth in utero, blood pressure in childhood and adult life, and mortality from CVD. BMJ 1989; 289: 564–567.Google Scholar
7. Geelhoed, JJM, Jaddoe, VWV. Early influences on cardiovascular and renal development. Eur J Epidemiol 2010; 25: 677–692.Google Scholar
8. Dawson, E, George, K, Shave, R, Whyte, G, Ball, D. Does the human heart fatigue subsequent to prolonged exercise? Sports Med 2003; 33: 365–380.Google Scholar
9. Oxborough, D, Birch, K, Shave, R, George, K. “Exercise-Induced Cardiac Fatigue” – a review of the echocardiographic literature. Echocardiography 2010; 27: 1130–1140.Google Scholar
10. Singh, JP, Larson, MG, Manolio, TA, et al. Blood pressure response during treadmill testing as a risk factor for new-onset hypertension: the framingham heart study. Circulation 1999; 14: 1831–1836.Google Scholar
11. Allison, TG, Cordeiro, M, Miller, T, Daida, H, Gau, GT. Prognostic significance of exercise-induced systemic hypertension in healthy subjects. Am J Cardiol 1999; 83: 371–375.Google Scholar
12. Kane, GC, Karon, BL, Mahoney, DW, et al. Progression of left ventricular diastolic dysfunction and risk of heart failure. JAMA 2011; 306: 856–863.Google Scholar
13. Banks, L, Sasson, Z, Busato, GM, Goodman, JM. Impaired left and right ventricular function following prolonged exercise in young athletes: influence of exercise intensity and responses to dobutamine stress. J Appl Physiol (1985) 2010; 108: 112–119.Google Scholar
14. Banks, L, Sasson, Z, Esfandiari, S, Busato, GM, Goodman, JM. Cardiac function following prolonged exercise: influence of age. J Appl Physiol (1985) 2011; 110: 1541–1548.Google Scholar
15. Rebbecca, M, Reynolds, BR, Walker, DI, Phillips, EM, Dennison, RF, Scott, MC. Programming of hypertension: associations of plasma aldosterone on adult men and women with birth weight, cortisol and blood pressure. Hypertension 2009; 53: 932–936.Google Scholar
16. Ijzerman, RG, Stehouwer, CD, de Geus, EJ, et al. Birth weight and sympathetic activity. Low birth weight is associated with increased sympathetic discharge: genetic factors. Circulation 2003; 108: 566–571.Google Scholar