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Evidence for a quantitative genetic influence on the formation of aortic valves with two leaflets in the Syrian hamster

Published online by Cambridge University Press:  19 August 2008

Valentín Sans-Coma ,
Manuel Cardo ,
Ana C. Durán ,
Diego Franco ,
Borja Fernández  and
José M. Arqué
Valentín Sans-Coma*
Affiliation:
From the Department of Animal Biology (Zoology), University of Málaga, Málaga
Manuel Cardo
Affiliation:
From the Department of Animal Biology (Zoology), University of Málaga, Málaga
Ana C. Durán
Affiliation:
From the Department of Animal Biology (Zoology), University of Málaga, Málaga
Diego Franco
Affiliation:
From the Department of Animal Biology (Zoology), University of Málaga, Málaga
Borja Fernández
Affiliation:
From the Department of Animal Biology (Zoology), University of Málaga, Málaga
José M. Arqué
Affiliation:
The Regional Hospital“Carlos Haya”, Málaga
*
Correspondence to Dr. Valentín Sans-Coma, Departamento de Biología Animal (Zoología), Facultad de Ciencias, Universidad de Málaga, E-29071, Málaga, Spain.
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Summary

We studied the morphology of the aortic valves of 1,036 Syrian hamsters belonging to two families subjected to high endogamous pressure. Most (n=955) specimens were examined using a corrosion-cast technique. In the remaining 81 specimens, valvar morphology was assessed by means of a stereomicroscope, and in 18 of these cases a histologic study was also performed. In one of the families, a high proportion (30.5%) of hamsters had aortic valves with two leaflets, the aortic sinuses being oriented ventrodorsally. The percentage of such anomalous valves was found to be positively correlated with the inbreeding coefficient of specimens. In the other family, the occurrence of an aortic valve with two leaflets was a sporadic event. Stereoscopic and histologic observations demonstrated that, in 52 of 63 aortic valves with three leaflets, the ventral commissure between the right and left leaflets was partially fused, while in 10 other cases this commissure was completely fused. In addition, in nine of 18 aortic valves with two leaflets, there was a more or less well-developed raphe located in the ventral aortic sinus, approximately where the true ventral commissure would have been. Our observations suggest the existence of a continuous spectrum of aortic valvar morphology, ranging from a valve with three leaflets and no fusion of the ventral commissure to an aortic valve with two leaflets devoid of any raphe. This spectrum seems to be the result of the interaction of genetic and intrauterine environmental factors. Results of crosses between both related and unrelated hamsters suggest that the observed morphology in individuals is the result of quantitative inheritance.

Keywords

Aortic valveanomalygeneticsSyrian hamster
Type
Original Articles
Information
Cardiology in the Young , Volume 3 , Issue 2 , April 1993 , pp. 132 - 140
Copyright
Copyright © Cambridge University Press 1993

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References

1.Roberts, WC. The two most common congenital heart dis-eases. Am J Cardiol 1984; 53: 1198.CrossRefGoogle Scholar
2.Roberts, WC. Congenital cardiovascular abnormalities usually silent until adulthood. In: Roberts, WC (ed). Adult Congenital Heart Disease. FA Davies Co, Phildelphia, 1987, pp 631–691.Google Scholar
3.Giusti, S, Cocco, P, Thiene, G. Valvola aortica bicuspide: una cardiopatia congenita “minore” a rischio di gravi complicanze. GItal Cardiol 1991; 21: 189–201.Google Scholar
4.Roberts, WC. Living with a congenitally bicuspid aortic valve. Am J Cardiol 1989; 64: 1408–1409.CrossRefGoogle ScholarPubMed
5.Roberts, WC. The congenitally bicuspid aortic valve. A study of 85 autopsy cases. Am J Cardiol 1970; 26: 72–83.CrossRefGoogle ScholarPubMed
6.Fenoglio, JJ, McAllister, HA, DeCastro, CM, Davia, JE, Cheitlin, MD. Congenital bicuspid aortic valve after age 20. Am J Cardiol 1977; 39: 164–169.CrossRefGoogle ScholarPubMed
7.Cheitlin, MD, Fenoglio, JJ, McAllister, HA, Davia, JE, DeCastro, CM. Congenital aortic stenosis secondary to dysplasia of congenital bicuspid aortic valves without commissural fusion. Am J Cardiol 1978; 42: 102–107.CrossRefGoogle ScholarPubMed
8.Edwards, WD, Leaf, DS, Edwards, JE. Dissecting aortic aneu- rysm associated with congenital bicuspid aortic valve. Circu lation 1978; 57: 1022–1025.CrossRefGoogle Scholar
9.Roberts, CHS, Roberts, WC. Dissection of the aorta associated with congenital malformation of the aortic valve. J Am Coll Cardiol 1991; 17: 712–716.CrossRefGoogle ScholarPubMed
10.Bankl, H. Congenital Malformations of the Heart and Great Vessels. Urban & Schwarzenberg, Baltimore, 1977, p. 127.Google Scholar
11.Branderburg, RO, Tajik, AJ, Edwards, WD, Reeder, GS, Shub, C, Seward, JB. Accuracy of 2-dimensional echocardiographic-anatomic correlation in 115 patients. Am J Cardiol 1983; 51: 1469–1473.CrossRefGoogle Scholar
12.Emanuel, R, Withers, R, O’Brien, K, Ross, P, Feizi, Ö. Congenitally bicuspid aortic valves. Clinicogenetic study of 41 fami lies. Br Heart J 1978; 40: 1402–1407.CrossRefGoogle Scholar
13.McDonald, K, Maurer, BJ. Familial aortic valve disease: evi dence for a genetic influence? Eur Heart J 1989; 10:676–677.CrossRefGoogle Scholar
14.Shaner, RF. Abnormal pulmonary and aortic semilunar valves in embryos. Anat Rec 1963; 147: 5–13.CrossRefGoogle ScholarPubMed
15.Moore, GW, Hutchins, GM, Brito, JC, Kang, H. Congenital malformations of the semilunar valves. Human Pathol 1980; 11:367–372.CrossRefGoogle ScholarPubMed
16.Clark, EB. Mechanisms in the pathogenesis of congenital cardiac malformations. In: Pierpont, MEM, Moller, JH (eds). Genetics of Cardiovascular Disease. Martinus Nijhoff Publishing, Boston, 1986, pp 3–11.Google Scholar
17.Kappetein, AP, Gittenberger-de, Groot AC, Zwinderman, AH, Rohmer, J, Poelmann, RE, Huysmans, HA. The neural crest as a possible pathogenetic factor in coarctation of the aorta and bicuspid aortic valve. J Thorac Cardiovasc Surg 1991; 102: 830–836.CrossRefGoogle ScholarPubMed
18.Sans-Coma, V, Arqué, JM, Durán, AC, Cardo, M, Fernández, B. Coronary artery anomalies and bicuspid aortic valves in the Syrian hamster. Basic Res Cardiol 1991; 86: 148–153.CrossRefGoogle ScholarPubMed
19.Falconer, DS. Introducción a la Genética Cuanti tativa. CECSA, Mexico, DF, 1989, pp 103–107.Google Scholar
20.Angelini, A, Ho, SY, Anderson, RH, Devine, WA, Zuberbuhler, JR, Becker, AE, Davies, MJ. The morphology of the normal aortic valve as compared with the aortic valve having two leaflets. J Thorac Cardiovasc Surg 1989; 98: 362–367.CrossRefGoogle ScholarPubMed
21.Sans-Coma, V, Cardo, M, Thiene, G, Fernández, B, Arqué, JM, Durán, AC. Bicuspid aortic and pulmonary valves in the Syrian hamster. IntJ Cardiol 1992; 34: 249–254.CrossRefGoogle ScholarPubMed
22.Ho, SY, Anderson, RH. The morphology of the aortic valve with regard to congenital malformations. In: Dunn, JM (ed). Cardiac Valve Disease. Elsevier Science Publishing, New York, 1988, pp 3–21.Google Scholar
23.Godden, DJ, Sandhu, PS, Kerr, F. Stenosed bicuspid aortic valves in twins. Eur Heart J 1987; 8: 316–318.CrossRefGoogle ScholarPubMed
24.Nora, JJ, Nora, AH. The evolution of specific genetic and environmental counseling in congenital heart diseases. Circu lation 1978;57:205–213.CrossRefGoogle ScholarPubMed
25.Lewis, NP, Henderson, AH. Calcific aortic stenosis in twins: a clue to its pathogenesis? Eur Heart J 1990; 11: 90–91.CrossRefGoogle ScholarPubMed
26.Campbell, M. Calcific aortic stenosis and congenital bicuspid aortic valves. Br Heart J 1968; 30: 606–616.CrossRefGoogle ScholarPubMed
27.Sánchez-Cascos, A. Genetica Cardiovascular. Jarpyo, Madrid, 1985, pp 66–69.Google Scholar
28.Braunwald, E. Heart Disease. A Textbook of Cardiovascular Medicine. WB Saunders, Philadelphia, 1988, p. 978.Google Scholar
29.Subramanian, R, Path, MRC, Olson, LJ, Edwards, WD. Surgical pathology of pure aortic stenosis: a study of 374 cases. Mayo Clin Proc 1984; 59: 683–690.CrossRefGoogle ScholarPubMed
30.Normand, J, Loire, R, Zambartas, C. The anatomical aspects of adult aortic stenosis. Eur HeartJ 1988; 9(Suppl E): 31–36.CrossRefGoogle ScholarPubMed