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Epidemiological investigation of Kawasaki disease in Jilin province of China from 2000 to 2008

Published online by Cambridge University Press:  26 April 2010

Jin-hua Piao ,
Lian-hua Jin ,
Jie Lv ,
Yan Zhou ,
Chun-ji Jin  and
Zheng-yong Jin
Jin-hua Piao*
Affiliation:
Department of Pediatrics, First Affiliated Hospital, Jilin University, Changchun, China
Lian-hua Jin
Affiliation:
Department of Pediatrics, First Affiliated Hospital, Jilin University, Changchun, China
Jie Lv
Affiliation:
Department of Pediatrics, First Affiliated Hospital, Jilin University, Changchun, China
Yan Zhou
Affiliation:
Department of Pediatrics, First Affiliated Hospital, Jilin University, Changchun, China
Chun-ji Jin
Affiliation:
Department of Pediatrics, First Affiliated Hospital, Yanbian University, Yanbian, China
Zheng-yong Jin
Affiliation:
Department of Pediatrics, First Affiliated Hospital, Yanbian University, Yanbian, China
*
Correspondence to: Jin-hua Piao, No. 1, Xinmin Street, Changchun City, Jilin Province, China. Tel: +86 024 23380681; Fax: +86 024 23380681; E-mail: [email protected]
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Abstract

Objective

To investigate the epidemiological characteristics of Kawasaki disease in Jilin province of China and explore its clinical features.

Methods

The medical records of children with Kawasaki disease hospitalised in the First Affiliated Hospital of Jilin University and Yanbian University between January, 2000 and December, 2008 were retrospectively analysed.

Results

A total of 735 children with Kawasaki disease were enrolled in this study with 483 boys and 252 girls. The ratio of male to female was 1.92:1. The ages of the children at onset varied from 51 days to 12 years with a mean age of 2.8 years. The children under the age of 5 years accounted for 79.5%, but most children were 2–3 years old. Kawasaki disease occurred all the year and more frequently in both the ending of spring and the beginning of summer. Fever was the most common clinical feature and enlarged cervical lymph nodes were the smallest clinical feature. A cardiovascular lesion was found in 41.4% of these children, in whom coronary artery dilatation was the most common (26.97%). A total of 117 (18.2%) of 643 children (87.5%) receiving intravenous immunoglobulin had a non-response to gamma globulin. Of the 117 children, 66 (56.4%) had cardiovascular lesion. Kawasaki disease recurred in 19 children (2.6%).

Conclusion

The incidence of Kawasaki disease in Jilin province has shown an increasing tendency. The age at onset is slightly higher than that described in other reports. Kawasaki disease is the most common in both the ending of spring and the beginning of summer, and the second incidence peak occurs in autumn.

Keywords

Clinical featuresincidenceincidence peak
Type
Original Articles
Information
Cardiology in the Young , Volume 20 , Issue 4 , August 2010 , pp. 426 - 432
Copyright
Copyright © Cambridge University Press 2010

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