Hostname: page-component-586b7cd67f-t7fkt Total loading time: 0 Render date: 2024-11-26T16:54:03.475Z Has data issue: false hasContentIssue false
  • English
  • Français

Epidemiological investigation of Kawasaki disease in Jilin province of China from 2000 to 2008

Published online by Cambridge University Press:  26 April 2010

Jin-hua Piao ,
Lian-hua Jin ,
Jie Lv ,
Yan Zhou ,
Chun-ji Jin  and
Zheng-yong Jin
Jin-hua Piao*
Affiliation:
Department of Pediatrics, First Affiliated Hospital, Jilin University, Changchun, China
Lian-hua Jin
Affiliation:
Department of Pediatrics, First Affiliated Hospital, Jilin University, Changchun, China
Jie Lv
Affiliation:
Department of Pediatrics, First Affiliated Hospital, Jilin University, Changchun, China
Yan Zhou
Affiliation:
Department of Pediatrics, First Affiliated Hospital, Jilin University, Changchun, China
Chun-ji Jin
Affiliation:
Department of Pediatrics, First Affiliated Hospital, Yanbian University, Yanbian, China
Zheng-yong Jin
Affiliation:
Department of Pediatrics, First Affiliated Hospital, Yanbian University, Yanbian, China
*
Correspondence to: Jin-hua Piao, No. 1, Xinmin Street, Changchun City, Jilin Province, China. Tel: +86 024 23380681; Fax: +86 024 23380681; E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective

To investigate the epidemiological characteristics of Kawasaki disease in Jilin province of China and explore its clinical features.

Methods

The medical records of children with Kawasaki disease hospitalised in the First Affiliated Hospital of Jilin University and Yanbian University between January, 2000 and December, 2008 were retrospectively analysed.

Results

A total of 735 children with Kawasaki disease were enrolled in this study with 483 boys and 252 girls. The ratio of male to female was 1.92:1. The ages of the children at onset varied from 51 days to 12 years with a mean age of 2.8 years. The children under the age of 5 years accounted for 79.5%, but most children were 2–3 years old. Kawasaki disease occurred all the year and more frequently in both the ending of spring and the beginning of summer. Fever was the most common clinical feature and enlarged cervical lymph nodes were the smallest clinical feature. A cardiovascular lesion was found in 41.4% of these children, in whom coronary artery dilatation was the most common (26.97%). A total of 117 (18.2%) of 643 children (87.5%) receiving intravenous immunoglobulin had a non-response to gamma globulin. Of the 117 children, 66 (56.4%) had cardiovascular lesion. Kawasaki disease recurred in 19 children (2.6%).

Conclusion

The incidence of Kawasaki disease in Jilin province has shown an increasing tendency. The age at onset is slightly higher than that described in other reports. Kawasaki disease is the most common in both the ending of spring and the beginning of summer, and the second incidence peak occurs in autumn.

Keywords

Clinical featuresincidenceincidence peak
Type
Original Articles
Information
Cardiology in the Young , Volume 20 , Issue 4 , August 2010 , pp. 426 - 432
Copyright
Copyright © Cambridge University Press 2010

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Newburger, JW, Takahashi, M, Gerber, MA, et al. Diagnosis, treatment, and long – term management of Kawasaki disease: a statement for health professionals from committee on rheumatic fever, endocarditis, and Kawasaki disease, council on cardiovascular disease in the young, American Heart Association. Pediatrics 2004; 114: 1708–1733.CrossRefGoogle Scholar
2. Liang, Y-C. Overview of Kawasaki disease in China. Chinese JPract Pediatr 1995; 10: 302–303.Google Scholar
3. Nakamura, Y, Yanagawa, H. The worldwide epidemiology of Kawasaki disease. Prog Ped Cardiol 2004; 19: 99–108.CrossRefGoogle Scholar
4. Nakamura, Y, Yashiro, M, Uehara, R, Oki, L, Watanabe, M, Yanagawa, H. Epidemiologic features of Kawasaki disease in Japan: result from the nationwide survey in 2005–2006. Epidemiol 2008; 18: 167–172.CrossRefGoogle ScholarPubMed
5. Holman, RC, Cums, AT, Belay, ED, Steiner, CA, Schonberqer, LB. Kawasaki syndrome hospitalizations in the United States, 1997 and 2000. Pediatrics 2003; 112: 495–501.CrossRefGoogle ScholarPubMed
6. Zhang, Y-L, Du, Z-D, Zhao, D, Du, J-B, Lu, S, Yi, J-M. Epidemiologic study on Children with Kawasaki disease in Beijing from 2000 to 2004. J Appl Clin Pediatr 2007; 22: 12–15.Google Scholar
7. Huang, GY. Epidemiologic pictures of Kawasaki disease in Shanghai from 1998 through 2002. J Epidemiol 2006; 16: 9–14.CrossRefGoogle ScholarPubMed
8. Wang, D-W, Hu, B-Z, Wang, F-M, Zhang, T-H, Kawasaki, F-Z, Liu, C-Y. Study on the epidemiological features of Kawasaki disease in Jiangsu. Zhonghua Liu Xing Bing Xue Za Zhi 2000; 21: 49–51.Google Scholar
9. Ma, Y-M, Du, Z-H, Li, L, Shi, M-R, Wan, Q, Fu, L-L. Study on epidemiology of Kawasaki disease in Yunan. Med Pharm Yunnan 2008; 29: 334–337.Google Scholar
10. Yanagawa, H, Sonobe, T. Changes in the diagnostic guidelines for Kawasaki disease. In: Yanagawa H, Nakamuru Y, Yashiro M, et al (eds). Epidemiology of Kawasaki Disease: A 30-year Achievement. Shindan To Chiryosha, Tokyo, 2004; 24–32.Google Scholar
11. De Zorzi, A, Colan, SD, Gauvreau, K, Baker, AL, Sundel, RP, Newburger, JW. Coronary artery dimensions may be misclassified as normal in Kawasaki disease. J Pediatr 1998; 133: 254–258.CrossRefGoogle ScholarPubMed
12. Kurotobi, S, Nagai, T, Kawakami, N, Sano, T. Coronary diameter in normal infants, children and patients with Kawasaki disease. Pediatr Int 2002; 44: 1–4.CrossRefGoogle ScholarPubMed
13. Tan, TH, Wong, KY, Cheng, TK, Heng, JT. Coronary normograms and the coronaryaorta index: objective determinants of coronary artery dilatation. Pediatr Cardiol 2003; 24: 328–335.CrossRefGoogle ScholarPubMed
14. Park, YW, Han, JW, Park, IS, et al. Epidemiologic picture of Kawasaki disease in Korea, 2000–2002. Pediatrics Int 2005; 47: 382–387.CrossRefGoogle ScholarPubMed
15. Chang, LY, Chang, IS, Lu, CY, et al. Epidemiologic features of Kawasaki disease in Taiwan, 1996–2002. J Pediatr 2004; 114: 678–682.CrossRefGoogle ScholarPubMed
16. Ng, YM, Sung, RY, So, LY, et al. Kawasaki disease in Hong Kong. Hong Kong Med J 2005; 11: 331–335.Google ScholarPubMed
17. Li, X-H, Li, X-J, Li, H, Wang, X-L, Xu, M, Zhang, T-H. Epidemiological investigation of Kawasaki disease during 1997–2000 in Sichuan Province. J Clin Pediatr 2006; 24: 306–308.Google Scholar
18. Jiao, F, Yang, L, Qiao, J, et al. Epidemiological and clinical characteristics of Kawasaki disease in Shaanxi province. Zhongguo Liu Xing Bing Xue Za Zhi 2000; 21: 79–99.Google Scholar
19. Genizi, J, Miron, D, Sp iegel, R, Fink, D, Horowitz, Y. Kawasaki disease in very young infants: high prevalence of atypical presentation and coronary arteritis. Clin Pediatr 2003; 42: 263–267.CrossRefGoogle ScholarPubMed
20. Huang, GY. Epidemiological status of Kawasaki disease. Chinese J Pract Pediatr 2006; 21: 721–723.Google Scholar
21. Bronstein, DE, Dille, AN, Austin, JP, Williams, CM, Palinkas, LA, Burns, JC. Relationship of climate, ethnicity and socioeconomic status to Kawasaki disease in San Diego County, 1994 through 1998. Pediatr Infect Dis J 2000; 19: 1087–1091.CrossRefGoogle Scholar
22. Zhou, T-P, Liao, B, Zuo, T-Q. Perianal desquamation in Kawasaki disease and its diagnostic value. J Appl Clin Pediatr 1992; 7: 149.Google Scholar
23. Kato, H. Cardiovascular complications in Kawasaki disease: coronary artery lumen and long-term consequences. Prog Pediatr Cardiol 2004; 19: 137–145.CrossRefGoogle Scholar
24. Wright, DA, Newburger, JW, Baker, A, Sundel, RP. Treatment of immune globlin-resistant Kawasaki disease. J Pediatr 1996; 128: 146–149.CrossRefGoogle ScholarPubMed
25. Sundel, RP, Baker, AL, Fulton, DR, Newburger, JW. Corticosteroids in the initial treatment of Kawasaki disease: report of a randomized trial. J Pediatr 2003; 142: 611–616.CrossRefGoogle ScholarPubMed
26. Jibiki, T, Terai, M, Kurosaki, T, et al. Efficacy of intravenous immune globulin therapy combined with dexamethasone for the initial treatment of acute Kawasaki disease. Eur J Pediatr 2004; 163: 229–233.CrossRefGoogle ScholarPubMed
27. Shulman, ST. Is there a role for cotiscosteroids in Kawasaki disease? J Pediatr 2003; 142: 601–603.CrossRefGoogle Scholar
28. Muta, H, Ishii, M, Furui, J, Nakamura, Y, Matsuishi, T. Risk factors associated with need for additional intravenous gammaglobulin therapy for Kawasaki disease. Acta Pediatr 2006; 95: 189–193.Google ScholarPubMed
29. Newhurger, JW, Takahashi, M, Beiser, AS, et al. A single intravenous infusion gamma globulin as compared with four infusion in the treatment of acute Kawasaki syndrome. N Engl J Med 1991; 324: 1633–1639.CrossRefGoogle Scholar
30. Li, Y-B, Yi, Q-J, Li, Q, et al. Which is the best dosage of intravenous immunoglobulin for treatment of Kawasaki disease: a comparative investigation on clinical and immunologic effects. Zhonghua Er Ke Za Zhi 1999; 37: 97–100.Google Scholar