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Embryology of congenital ventriculo-coronary communications: a study on quail-chick chimeras

Published online by Cambridge University Press:  19 August 2008

Jörg Männer
Jörg Männer*
Affiliation:
Department of Embryology, Center of Anatomy, Göttingen University, Göttingen, Germany
*
Dr. J. Männer, Dept. of Embryology, Center of Anatomy, Göttingen University, Kreuzbergring 36, D–37075 Göttingen, Germany. Tel: (49) 551–39 7032; Fax: (49) 551–39 7043
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Abstract

Ventriculo-coronary arterial communications are rare congenital heart defects which have been explained traditionally on the basis of abnormal persistence of such communications found in the normal developing heart. Recent studies, however, have suggested that these embryonic communications might be an incidental finding rather than a normal feature. Thus, it has been suggested that congenital ventriculo-coronary communications do not represent remnants of normal embryonic vessels, but rather represent acquired lesions. In the present study, hearts were constructed in embryonic chicks in which the coronary vasculature was almost completely derived from a quail-donor. After immunohistochemical staining of the quail-derived coronary endothelium, chimeric hearts were analysed with respect to the presence of embryonic ventriculo-coronary communications, and with respect to the origin of these structures from either coronary arteries or endocardium. The results demonstrate the normal presence of ventriculo-coronary communications in avian embryonic hearts. They show, furthermore, that these structures are of coronary endothelial origin. The findings are in accord with the traditional view on the pathogenesis of congenital ventriculo-coronary communications. The roles of elevated ventricular pressure, abnormal remodelling of the developing myocardium, and of abnormal growth of the coronary vasculature are discussed relative to the pathogenesis of congenital ventriculo-coronary communications.

Keywords

Congenital heart diseaseventriculo-coronary communicationsembryology
Type
Original Articles
Information
Cardiology in the Young , Volume 10 , Issue 3 , May 2000 , pp. 233 - 238
Copyright
Copyright © Cambridge University Press 2000

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References

1.Kauffman, SL, Andersen, DH. Persistent venous valves, malde velopment of the right heart, and coronary artery-ventricular communications. Am Heart J 1963; 66: 664–669.CrossRefGoogle Scholar
2.Baker, WP, Vogel, JHK, Blount, SG. Coronary artery-right ventricular comitiunication associated with pulmonary atresia and ventricular septal defect. Circulation 1967; 35: 923–927.CrossRefGoogle ScholarPubMed
3.Kasznica, J, Ursell, PC, Blanc, WA, Gersony, WM. Abnormalities of the coronary circulation in pulmonary arresia and intact ventricular septum. Am Heart J 1987; 114: 1415–1420.CrossRefGoogle ScholarPubMed
4.O'Connor, WN, Stahr, BJ, Cottrill, CM, Todd, EP, Noonan, JA. Ventriculocoronary connections in hypoplastic right heart syndrome: autopsy serial section study of six cases. J Am Coil Cardiol 1988; 11: 1061–1072.CrossRefGoogle ScholarPubMed
5.Gitrenberger-de Groot, AC, Sauer, U, Binde, L, Babic, R, Essed, CE, Bühlmeyer, K. Competition of coronary arteries and ventriculo-coronary arterial communications in pulmonary atresia with intact ventricular septum. Int J Cardiol 1988; 18: 243–258.CrossRefGoogle Scholar
6.Upshaw, CB. Congenital coronary arteriovenous fistula. Report of a case with an analysis of seventy-three reported cases. Am Heart J 1962; 63: 399–404.CrossRefGoogle ScholarPubMed
7.McNamara, JJ, Gross, RE. Congenital coronary artery fistula. Surgery 1969; 65: 59–69.Google ScholarPubMed
8.Grant, RT. An unusual anomaly of the coronary vessels in the malformed heart of a child. Heart 1926; 13: 272–283.Google Scholar
9.Dusek, J, Ostadal, B, Duskova, M. Postnatal persistence of spongy myocardium with embryonic blood supply. Arch Pathol 1975; 99: 312–317.Google ScholarPubMed
10.O'Connor, WN, Cash, JB, Cottrill, CM, Johnson, GL, Noonan, JA. Ventriculocoronary connections in hypoplastic left hearts: an autopsy microscopic study. Circulation 1982; 66: 1078–1086.CrossRefGoogle ScholarPubMed
11.Shiota, K, Kinoshita, M, Kimura, N, Kurusu, H, Kuwahara, K, Mon, C. Multiple fistulae of coronary arteries to both ventricles. Jpn Heart J 1988; 29: 741–746.CrossRefGoogle ScholarPubMed
12.Poelmann, RE, Gittenberger-de Groot, AC, Mentink, MMT, Bokenkamp, R, Hogers, B. Development of the cardiac coronary vascular endothelium, studied with antiendorhelial antibodies, in chicken-quail chimeras. Circulation Res 1993; 73: 559–568.CrossRefGoogle ScholarPubMed
13.Vrancken Peeters, M-PFM, Girtenberger-de Groot, AC, Mentink, MMT, Hungerford, JE, Little, CD, Poelmann, RE. The development of the coronary vessels and their differentiation into arteries and veins in the embryonic quail heart. Dev Dyn 1997; 208: 338–348.3.0.CO;2-J>CrossRefGoogle ScholarPubMed
14.Grant, RT. Development of the cardiac coronary vessels in the rabbit. Heart 1926; 13: 261–271.Google Scholar
15.Bennett, HS. The development of the blood supply to the heart in the embryo pig. Am J Anat 1936; 60: 27–53.CrossRefGoogle Scholar
16.Goldsmith, JE, Butler, HV. The development of the cardiac coronary circulatory system. Am) Anat 1937; 60: 185–201.CrossRefGoogle Scholar
17.Steinhoff, W. Zur Enrwicklung der terminalen Strombahn im Hühnerherzen. Z Anat Entwickl Gesch 1971; 134: 255–277.CrossRefGoogle Scholar
18.Rychterov, V. Formation of the terminal vascular bed in the chick embryo. Folia Morphol (Prague) 1977; 25: 7–14.Google Scholar
19.Wearn, JT, Mettier, SR, Klumpp, TG, Zschiesche, LJ. The nature of the vascular communications between the coronary arteries and the chambers of the heart. Am Heart J 1933; 9: 143–164.CrossRefGoogle Scholar
20.Prinzmetal, M, Simkin, B, Bergman, HC, Kruger, HE. Studies on the coronary circulation. II. The collateral circulation of the normal human heart by coronary perfusion with radioactive erythrocytes and glass spheres. Am Heart J 1947; 33: 420–442.CrossRefGoogle Scholar
21.Smith, GT. The anatomy of the coronary circulation. Am J Cardiol 1962; 9: 327–342.CrossRefGoogle ScholarPubMed
22.Esperança Pina, JA, Monteiro Triridade, A. Etude microan giographique des vaisseux artério-luminaux. Acta Anat 1977; 98: 334–339.CrossRefGoogle Scholar
23.Tota, B, Cimini, V, Salvatore, G, Zummo, G. Comparative study of the arterial and lacunary systems of the ventricular myocardium of elasmobranch and teleost fishes. Am J Anat 1983; 167: 15–32.CrossRefGoogle ScholarPubMed
24.Männer, J. The development of pericardial villi in the chick embryo. Anat Embryol 1992; 186: 379–385.CrossRefGoogle ScholarPubMed
25.Mäanner, J. Experimental study on the formation of the epicardiurn in chick embryos. Anat Embryol 1993; 187: 281–289.CrossRefGoogle Scholar
26.Pérez-Pornares, JM, Macias, D, Garcia-Garrido, L, Muñoz Chipuli, R. The origin of the subepicardial mesenchyme in the avian embryo: an immunohistochemical and quail-chick chimera study. Dev Biol 1998; 200: 57–68.CrossRefGoogle Scholar
27.Manner, J. Does the subepicardial mesenchyme contribute myocardioblasts to the chick embryo heart? A quail-chick chimera study tracing the fate of the epicardial primorium. Anat Rec 1999; 255: 212–226.3.0.CO;2-X>CrossRefGoogle Scholar
28.Hamburger, V, Hamilton, HL. A series of normal stages in the development of the chick embryo. J Morphol 1951; 88: 49–92.CrossRefGoogle ScholarPubMed
29.Sanders, EJ. A comparison of the adhesiveness of somitic cells from chick and quail embryos. In: Bellairs, R, Ede, DA, Lash, GW (eds). Somites of developing embryos. Nato Asi Series 118, Plenum Press, New York, 1986, pp 191–200.CrossRefGoogle Scholar
30.Edwards, JE. Anomalous coronary arteries with special reference to arteriovenous-like communications. Circulation 1958; 17: 1001–1006.CrossRefGoogle ScholarPubMed
31.Yokose, T, Doi, M, Kimura, Y, Ogata, T. Ventriculo-coronary micro-communications in pulmonary atresia and sequential changes of coronary arteries. Acts Pathol Jpn 1987; 37: 1033–1040.Google ScholarPubMed
32.Morgan, JR, Forker, AD, O'Sullivan, MJ Jr., Fosburg, RG. Coronary arterial fistulas: seven cases with unusual features. Am J Cardiol 1972; 30: 432–436.CrossRefGoogle ScholarPubMed