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A Dobutamine paradox: eosinophilic myocarditis in the explanted heart of a 9-year-old girl undergoing cardiac transplantation

Published online by Cambridge University Press:  16 September 2005

Matthew Fenton ,
Mike Burch  and
Neil Sebire
Matthew Fenton
Affiliation:
Department of Cardiology, Great Ormond Street Hospital, London, United Kingdom
Mike Burch
Affiliation:
Department of Cardiology, Great Ormond Street Hospital, London, United Kingdom
Neil Sebire
Affiliation:
Department of Histopathology, Great Ormond Street Hospital, London, United Kingdom
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Abstract

We describe a 9-year-old girl who was noted to have eosinophilic myocarditis in her native heart after it was explanted during cardiac transplantation. On the basis of absence of evidence for primary or secondary eosinophilia, we suggest that the prolonged use of dobutamine prior to transplantation might have induced the eosinophilic myocarditis.

Keywords

Cardiomyopathyinotropeschildren
Type
Brief Report
Information
Cardiology in the Young , Volume 15 , Issue 5 , October 2005 , pp. 520 - 522
Copyright
© 2005 Cambridge University Press

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References

Takkenberg JJ, Czer LS, Fishbein MC, et al. Eosinophilic myocarditis in patients awaiting heart transplantation. Crit Care Med 2004; 32: 714–721.Google Scholar
Aretz HT, Billingham ME, Edwards WD, et al. Myocarditis. A histopathologic definition and classification. Am J Cardiovasc Pathol 1987; 1: 3–14.Google Scholar
Johnson MR. Eosinophilic myocarditis in the explanted hearts of cardiac transplant recipients: Interesting pathologic finding or pathophysiologic entity of clinical significance? Crit Care Med 2004; 32: 888–890.Google Scholar
Arbustini E, Gavazzi A, Dal Bello B, et al. Ten-year experience with endomyocardial biopsy in myocarditis presenting with congestive heart failure: frequency, pathologic characteristics, treatment and follow-up. G Ital Cardiol 1997; 27: 209–223.Google Scholar
Aoki Y, Nata M, Hashiyada M, Sagisaka K. Sudden unexpected death in childhood due to eosinophilic myocarditis. Int J Legal Med 1996; 108: 221–224.Google Scholar
Horenstein MS, Humes R, Epstein ML, Draper D. Loffler's endocarditis presenting in 2 children as fever with eosinophilia. Pediatrics 2002; 110: 1014–1018.Google Scholar
Herzog CA, Snover DC, Staley NA. Acute necrotising eosinophilic myocarditis. Br Heart J 1984; 52: 343–348.Google Scholar
Kishimoto C, Spry CJ, Tai PC, Tomioka N, Kawai C. The in vivo cardiotoxic effect of eosinophilic cationic protein in an animal preparation. Jpn Circ J 1986; 50: 1264–1267.Google Scholar