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Current insights in diagnosis and management of the cardiovascular complications of Marfan's syndrome

Published online by Cambridge University Press:  30 July 2009

Gijs J. Nollen ,
Maarten Groenink ,
Ernst E. van der Wall  and
Barbara J. M. Mulder
Gijs J. Nollen
Affiliation:
Department of Cardiology, Academic Medical Center Amsterdam, Amsterdam, The Netherlands
Maarten Groenink
Affiliation:
Department of Cardiology, Academic Medical Center Amsterdam, Amsterdam, The Netherlands
Ernst E. van der Wall
Affiliation:
Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
Barbara J. M. Mulder*
Affiliation:
Department of Cardiology, Academic Medical Center Amsterdam, Amsterdam, The Netherlands
*
Department of Cardiology, Room B2-240, Academic Medical Center Amsterdam (AMC), Meibergdreef 9, 1100 DD Amsterdam, The Netherlands. Tel: +31 20 5667731; Fax: +31 20 5666809; E-mail: [email protected]
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Abstract

Marfan's syndrome is an inherited disorder of connective tissue, caused by mutations in the fibrillin-1 gene located on chromosome 15. Diagnosis is still based on a combination of major and minor clinical features. Prognosis is mainly determined by the cardiovascular complications. Advances in surgical and medical treatment for these complications have dramatically improved the prognosis of the syndrome.

Keywords

Aortic aneurysmaortic dissectionsurvival
Type
Review
Information
Cardiology in the Young , Volume 12 , Issue 4 , July 2002 , pp. 320 - 327
Copyright
Copyright © Cambridge University Press 2002

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