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Cardiac involvement in Multisystem Inflammatory Syndrome in Children cases

Published online by Cambridge University Press:  17 December 2021

Nurdan Erol Open the ORCID record for Nurdan Erol [Opens in a new window]  and
Erdal Sari
Nurdan Erol*
Affiliation:
Health Sciences University Zeynep Kamil Gynecology and Pediatrics Training and Research Hospital, Pediatric Clinics, Dr. Burhanettin Ustunel Sokagi No:10, 34668 Uskudar/Istanbul, Turkey
Erdal Sari
Affiliation:
Health Sciences University Zeynep Kamil Gynecology and Pediatrics Training and Research Hospital, Pediatric Clinics, Dr. Burhanettin Ustunel Sokagi No:10, 34668 Uskudar/Istanbul, Turkey
*
Author for correspondence: Nurdan Erol, M.D., Pediatric Cardiologist, Health Sciences University Zeynep Kamil Gynecology and Pediatrics Training and Research Hospital, Pediatric Clinics, Dr. Burhanettin Ustunel Sokagi No:10, 34668 Uskudar/Istanbul, Turkey. Tel: +905057588787. E-mail: [email protected]
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Abstract

Multisystem Inflammatory Syndrome in Children is a rare form of COVID-19 that affects various organ systems and carries the risk of morbidity and mortality. Cardiac involvement is commonly observed in Multisystem Inflammatory Syndrome in Children cases; hence, this study was conducted to evaluate the cardiac findings of the Multisystem Inflammatory Syndrome in Children cases that were diagnosed and followed up in our hospital.

Materials and methods:

The medical histories, laboratory results, cardiac findings, and treatments of the cases that were diagnosed with Multisystem Inflammatory Syndrome in Children between December 2020 and August 2021 were evaluated retrospectively.

Results:

Our study group consisted of 14 males and 12 females whose median age was 3.67 years. Of the 26 patients, 24 had echocardiographic findings and 12 cases had cardiac pathologies that were mostly mild. Among these, mitral valve insufficiency, coronary artery pathology, and pericardial effusion were the most common. Perivascular brightness, aortic and tricuspid insufficiency, systolic dysfunction, and tricuspid thrombosis were less common. The cardiac pathologies of all patients resolved in less than a month following treatment.

Conclusion:

Although the cardiac pathologies of Multisystem Inflammatory Syndrome in Children cases disappear fairly rapidly, the long-term cardiac effects of this disease are not known clearly. To improve our current understanding of Multisystem Inflammatory Syndrome in Children, more multi-centred studies with long-term follow-up periods should be conducted, and treatment protocols for cases of different severities should be developed to maximise the treatments’ efficacy.

Keywords

COVID-19Multisystem Inflammatory Syndrome in ChildrenCardiac pathologyEchocardiography
Type
Original Article
Information
Cardiology in the Young , Volume 32 , Issue 11 , November 2022 , pp. 1780 - 1785
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Copyright
© The Author(s), 2021. Published by Cambridge University Press

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References

Sperotto, S, Friedman, KG, Son, MBF, et al. Cardiac manifestations in SARS-CoV-2-associated multisystem inflammatory syndrome in children: a comprehensive review and proposed clinical approach. Eur J Pediatr 2021; 180: 307–322.CrossRefGoogle ScholarPubMed
Ludvigsson, JF. Systematic review of COVID-19 in children shows milder cases and a better prognosis than adults. Acta Paediatr 2020; 109: 1088–1095.CrossRefGoogle Scholar
Riphagen, S, Gomez, X, Gonzalez-Martinez, C, et al. Hyperinflammatory shock in children during COVID-19 pandemic. Lancet 2020; 395: 1607–1608.CrossRefGoogle ScholarPubMed
Henderson, LA, Canna, SW, Friedman, KG, et al. American college of rheumatology clinical guidance for multisystem inflammatory syndrome in children associated with SARS-CoV-2 and hyperinflammation in pediatric COVID-19: version 1. Arthritis Rheumatol. 2020; 72: 1791–1805.CrossRefGoogle ScholarPubMed
Swann, OV, Holden, KA, Turtle, L, et al. Clinical characteristics of children and young people admitted to hospital with covid-19 in United Kingdom: prospective multicentre observational cohort study. BMJ 2020; 370: 3249.CrossRefGoogle Scholar
Feldstein, LR, Rose, EB, Horwitz, SM, et al. Multisystem inflammatory syndrome in US children and adolescents. N Engl J Med 2020; 383: 334–346.CrossRefGoogle Scholar
Matsubara, D, Kauffman, HL, Wang, Y, et al. Echocardiographic findings in pediatric multisystem inflammatory syndrome associated with COVID-19 in the United States. Am Coll Cardiol 2020; 76: 1947–1961.CrossRefGoogle ScholarPubMed
Dufort, EM, Koumans, EH, Chow, EJ, et al. Multisystem inflammatory syndrome in children in New York State. N Engl J Med 2020; 383: 347–358.CrossRefGoogle ScholarPubMed
Beroukhim, RS, Friedman, KG. Children at risk multisystem inflammatory syndrome and COVID-19. JACC: Case Rep 2020; 2: 1271–1274.Google ScholarPubMed
Wald, ER, Schmit, KM, Gusland, DY. A pediatric infectious disease perspective on COVID-19. Clin. Infect. Dis® 2021; 72: 1660–1666.CrossRefGoogle ScholarPubMed
McArdle, AJ, Vito, O, Patel, H, et al. Treatment of multisystem inflammatory syndrome in children. N Engl J Med. 2021; 385: 11–22.CrossRefGoogle ScholarPubMed
Guana, R, Pagliara, C. Multisystem inflammatory syndrome in SARS-CoV-2 infection mimicking acute appendicitis in children. Pediatr. Neonatol 2021; 62: 122–124.CrossRefGoogle ScholarPubMed
Rafferty, MS, Burrows, H, Joseph, JP, et al. Multisystem inflammatory syndrome in children (MIS-C) and thecoronavirus pandemic: current knowledge and implications forpublic health. J Infect Pub Health 2021; 14: 484–494.CrossRefGoogle Scholar
Henderson, LA, Canna, SW, Friedman, KG, et al. American college of rheumatology clinical guidance for multisystem inflammatory syndrome in children associated with SARS-CoV-2 and hyperinflammation in pediatric COVID-19: version 2. Arthritis Rheumatol. 2021; 73: e13–e29.CrossRefGoogle ScholarPubMed
Hoste, L, Van Paemel, R, Haerynck, F. Multisystem inflammatory syndrome in children related to COVID-19: a systematic review. Eur J Pediatr. 2021; 180: 2019–2034.CrossRefGoogle ScholarPubMed
Minocha, PK, Phoon, CKL, Verma, S, et al. Cardiac findings in pediatric patients with multisystem inflammatory syndrome in children associated with COVID-19. Clin Pediatr 2021; 60: 119–126.CrossRefGoogle ScholarPubMed