Hostname: page-component-78c5997874-j824f Total loading time: 0 Render date: 2024-11-05T07:55:52.859Z Has data issue: false hasContentIssue false
  • English
  • Français

Association between left ventricular ejection fraction and Kawasaki disease shock syndrome

Published online by Cambridge University Press:  20 February 2019

Huixian Qiu ,
Chen Li ,
Yuee He ,
Fengfeng Weng ,
Hongying Shi ,
Lulu Pan ,
Yuping Guo ,
Yuanhai Zhang ,
Rongzhou Wu  and
Maoping Chu
Huixian Qiu
Affiliation:
Department of Children’s Heart Center, The Second Affiliated Hospital and Yuying Children’s Hospital, Institute of Cardiovascular Development and Translational Medicine, Wenzhou Medical University, Wenzhou, China
Chen Li
Affiliation:
Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
Yuee He
Affiliation:
Department of Children’s Heart Center, The Second Affiliated Hospital and Yuying Children’s Hospital, Institute of Cardiovascular Development and Translational Medicine, Wenzhou Medical University, Wenzhou, China
Fengfeng Weng
Affiliation:
Department of Children’s Heart Center, The Second Affiliated Hospital and Yuying Children’s Hospital, Institute of Cardiovascular Development and Translational Medicine, Wenzhou Medical University, Wenzhou, China
Hongying Shi
Affiliation:
Department of Preventive Medicine, School of Environmental Science and Public Health, Wenzhou Medical University, Wenzhou, Zhejiang, China
Lulu Pan
Affiliation:
Department of Children’s Heart Center, The Second Affiliated Hospital and Yuying Children’s Hospital, Institute of Cardiovascular Development and Translational Medicine, Wenzhou Medical University, Wenzhou, China
Yuping Guo
Affiliation:
Department of Children’s Heart Center, The Second Affiliated Hospital and Yuying Children’s Hospital, Institute of Cardiovascular Development and Translational Medicine, Wenzhou Medical University, Wenzhou, China
Yuanhai Zhang
Affiliation:
Department of Children’s Heart Center, The Second Affiliated Hospital and Yuying Children’s Hospital, Institute of Cardiovascular Development and Translational Medicine, Wenzhou Medical University, Wenzhou, China
Rongzhou Wu
Affiliation:
Department of Children’s Heart Center, The Second Affiliated Hospital and Yuying Children’s Hospital, Institute of Cardiovascular Development and Translational Medicine, Wenzhou Medical University, Wenzhou, China
Maoping Chu*
Affiliation:
Department of Children’s Heart Center, The Second Affiliated Hospital and Yuying Children’s Hospital, Institute of Cardiovascular Development and Translational Medicine, Wenzhou Medical University, Wenzhou, China
*
Author for correspondence: M. Chu, Department of Children’s Heart Center, The Second Affiliated Hospital and Yuying Children’s Hospital, Institute of Cardiovascular Development and Translational Medicine, Wenzhou Medical University, Wenzhou 325000, China. Tel: +86-13857796736; Fax: +86-057788832693; E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective

This study was performed to explore the clinical features of Kawasaki disease shock syndrome and analyse the association between the left ventricular ejection fraction and Kawasaki disease shock syndrome.

Methods

We retrospectively reviewed the medical records of all consecutive inpatients with Kawasaki disease at Wenzhou Medical University Second Affiliated Hospital and Yuying Children’s Hospital in Wenzhou, China from January 2009 to December 2016. We compared the clinical characteristics, laboratory data, and left ventricular ejection fraction between patients with and without Kawasaki disease shock syndrome and analysed the effect of the left ventricular ejection fraction on Kawasaki disease shock syndrome under different clinical conditions of Kawasaki disease.

Results

In total, 1147 patients were diagnosed with Kawasaki disease. Of these 1147 patients, 17 were diagnosed with Kawasaki disease shock syndrome; 68 patients admitted to the hospital at the same time, ±2 weeks, with Kawasaki disease but without Kawasaki disease shock syndrome served as the control group. Compared with the control group, the Kawasaki disease shock syndrome group had a significantly higher incidence of coronary artery lesions, cardiac troponin I concentration, N-terminal prohormone of brain natriuretic peptide concentration, neutrophil count and ratio, alanine aminotransferase concentration, aspartate aminotransferase concentration, and C-reactive protein concentration and a significantly lower platelet count, serum albumin concentration, and left ventricular ejection fraction. A low left ventricular ejection fraction was associated with Kawasaki disease shock syndrome under different conditions of Kawasaki disease.

Conclusion

Among patients with Kawasaki disease, cardiac injury is more likely in those with Kawasaki disease shock syndrome than without, and a low left ventricular ejection fraction may be associated with the development of Kawasaki disease shock syndrome.

Keywords

Kawasaki diseaseshockleft ventricular ejection fraction
Type
Original Article
Information
Cardiology in the Young , Volume 29 , Issue 2 , February 2019 , pp. 178 - 184
Copyright
© Cambridge University Press 2019 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

*

Huixian Qiu and Chen Li contributed equally to the writing of this article.

Cite this article: Qiu H, Li C, He Y, Weng F, Shi H, Pan L, Guo Y, Zhang Y, Wu R, Chu M. (2019) Association between left ventricular ejection fraction and Kawasaki disease shock syndrome. Cardiology in the Young29: 178–184. doi: 10.1017/S1047951118002056

References

1. JCS Joint Working Group. Guidelines for diagnosis and management of cardiovascular sequelae in Kawasaki disease (JCS 2013). Digest version. Circ J 2014; 78: 2521–2562.Google Scholar
2. Dominguez, SR, Friedman, K, Seewald, R, Anderson, MS, Willis, L, Glodé, MP. Kawasaki disease in a pediatric intensive care unit: a case-control study. Pediatrics 2008; 122: e786–e790.Google Scholar
3. Kanegaye, JT, Wilder, MS, Molkara, D, et al. Recognition of a Kawasaki disease shock syndrome. Pediatrics 2009; 123: e783–e789.Google Scholar
4. Chen, PS, Chi, H, Huang, FY, Peng, CC, Chen, MR, Chiu, NC. Clinical manifestations of Kawasaki disease shock syndrome: a case-control study. J Microbiol Immunol Infect 2015; 48: 43–50.Google Scholar
5. Taddio, A, Rossi, ED, Monasta, L, et al. Describing Kawasaki shock syndrome: results from a retrospective study and literature review. Clin Rheumatol 2017; 36: 223–228.Google Scholar
6. Lin, MT, Fu, CM, Huang, SK, Huang, SC, Wu, MH. Population-based study of Kawasaki disease shock syndrome in Taiwan. Pediatr Infect Dis J 2013; 32: 1384–1386.Google Scholar
7. Newburger, JW, Takahashi, M, Gerber, MA, et al; Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association. Diagnosis, treatment, and long-term management of Kawasaki disease: a statement for health professionals from the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association. Pediatrics 2004; 114: 1708–1733.Google Scholar
8. Shin, JI, Lee, JS. Beneficial effect of intravenous immunoglobulins on systemic capillary leak syndrome in patients with monoclonal gammopathy. Crit Care Med 2009; 37: 795, author reply 795.Google Scholar
9. Gatterre, P, Oualha, M, Dupic, L, et al. Kawasaki disease: an unexpected etiology of shock and multiple organ dysfunction syndrome. Intensive Care Med 2012; 38: 872–878.Google Scholar
10. Poddighe, D. Common finding of mild hyponatremia in children evaluated at the Emergency Department and its correlation with plasma C-reactive protein values. Minerva Pediatr 2016; 68: 173–176.Google Scholar
11. Schuster, JE, Palac, HL, Innocentini, N, Rowley, AH, Young, LT, Shulman, ST. Hyponatremia is a feature of Kawasaki disease shock syndrome: a case-control study. J Pediatric Infect Dis Soc 2017; 6: 386–388.Google Scholar
12. Gámez-González, LB, Murata, C, Muñoz-Ramírez, M, et al. Clinical manifestations associated with Kawasaki disease shock syndrome in Mexican children. Eur J Pediatr 2013; 172: 337–342.Google Scholar
13. Druey, KM, Greipp, PR. Narrative review: the systemic capillary leak syndrome. Ann Intern Med 2010; 153: 90–98.Google Scholar
14. Li, HY, Jiang, LM, Zheng, JX, Sun, X, Fu, QH. The establishment of pediatric reference intervals for creatine kinase-MB and troponin I. Zhonghua Jianyan Yixue Zazhi 2012; 35: 1142–1145.Google Scholar
15. Checchia, PA, Borensztajn, J, Shulman, ST. Circulating cardiac troponin I levels in Kawasaki disease. Pediatr Cardiol 2001; 22: 102–106.Google Scholar
16. Flynn, E, Kowalski, R, Burgner, D. Kawasaki disease shock syndrome with retrograde diastolic aortic flow. J Pediatr 2016; 170: 336–e1.Google Scholar