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Assessment of myocardial function in preterm infants with patent ductus arteriosus using tissue Doppler imaging

Published online by Cambridge University Press:  16 October 2013

Ravikumar Parikh ,
Robert J. S. Negrine ,
Ashish Chikermane ,
Shree Vishna Rasiah  and
Andrew K. Ewer
Ravikumar Parikh*
Affiliation:
Department of Neonatology, Birmingham Women’s Hospital NHS Trust, Birmingham, B15 2TG, United Kingdom
Robert J. S. Negrine
Affiliation:
Department of Neonatology, Birmingham Women’s Hospital NHS Trust, Birmingham, B15 2TG, United Kingdom
Ashish Chikermane
Affiliation:
Department of Paediatric Cardiology, Birmingham Children’s Hospital NHS Trust, Birmingham, B4 6NH, United Kingdom
Shree Vishna Rasiah
Affiliation:
Department of Neonatology, Birmingham Women’s Hospital NHS Trust, Birmingham, B15 2TG, United Kingdom
Andrew K. Ewer
Affiliation:
Department of Neonatology, Birmingham Women’s Hospital NHS Trust, Birmingham, B15 2TG, United Kingdom School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, B15 2 TT, United Kingdom
*
Correspondence to: Dr Ravikumar Parikh, Department of Neonatology, Birmingham Women’s Hospital, Edgbaston, Birmingham, B15 2TG, United Kingdom. Tel: +(44) 7944304803; Fax: +(44) 121 627 2646; E-mail: [email protected]
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Abstract

Objective: To assess myocardial function in preterm infants with different degrees of ductal patency in the first week of life using tissue Doppler imaging. Study design: Infants <30 weeks of gestation underwent echocardiography on day 3. A total of 72 infants were recruited into the study and categorised into three groups (i) haemodyamically significant ductus arteriosus, (ii) patent ductus arteriosus and (iii) no patent ductus arteriosus. Those with haemodynamically significant ductus arteriosus were treated with indometacin and echocardiography was repeated after 48–72 hours following treatment. Peak systolic and diastolic myocardial velocities were obtained using tissue Doppler imaging, and myocardial performance index was calculated. Results: Initial myocardial velocities were significantly lower and myocardial performance index significantly higher in the haemodynamically significant ductus arteriosus group compared with other groups. For the haemodynamically significant ductus arteriosus group, post-treatment myocardial velocities were higher and myocardial performance index lower than pre-treatment. Conclusion: Preterm infants with haemodynamically significant ductus arteriosus had lower myocardial velocities and higher myocardial performance index, suggesting relative systolic and diastolic myocardial dysfunction. Babies whose patent ductus arteriosus remained open despite indometacin had lower pre-treatment myocardial velocities and higher myocardial performance index than those babies whose patent ductus arteriosus closed, suggesting worse myocardial function in this group. Measurement of myocardial function using tissue Doppler imaging in preterm infants is feasible and may prove to be helpful in the management of babies with patent ductus arteriosus.

Keywords

Premature infantsneonatetissue Doppler imagingmyocardial performance indexpatent ductus arteriosusvery low birth weight infants
Type
Original Articles
Information
Cardiology in the Young , Volume 25 , Issue 1 , January 2015 , pp. 70 - 75
Copyright
Copyright © Cambridge University Press 2013 

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References

1. Koch, J, Hensley, G, Roy, L, et al. Prevalence of spontaneous closure of the ductus arteriosus in neonates at birth weight of 1000 grams or less. Pediatrics 2006; 117: 1113–1121.Google Scholar
2. Trus, T, Winthrop, AL, Pipe, S, et al. Optimal management of patent ductus arteriosus in the neonate weighing less than 800 g. J Pediatr Surg 1993; 28: 1137–1139.CrossRefGoogle Scholar
3. Hamrick, SEG, Hansmann, G. Patent ductus arteriosus of the preterm infant. Pediatrics 2010; 125: 1020–1030.CrossRefGoogle ScholarPubMed
4. Rojas, MA, Gonzalez, A, Bancalari, E, et al. Changing trends in the epidemiology and pathogenesis of neonatal chronic lung disease. J Pediatr 1995; 126: 605–610.Google Scholar
5. Garland, J, Buck, R, Weinberg, M. Pulmonary haemorrhage risk in infants with a clinically diagnosed patent ductus arteriosus: a retrospective cohort study. Paediatrics 1994; 94: 719–723.CrossRefGoogle ScholarPubMed
6. Clyman, RI, Chrone, N. Patent ductus arteriosus: evidence for and against treatment. J Pediatr 2007; 150: 216–219.Google Scholar
7. Evans, N, Kluckow, M. Early ductal shunting and intraventricular haemorrhage in ventilated preterm infants. Arch Dis Child Fetal Neonatal E 1996; 75: F183–F186.CrossRefGoogle ScholarPubMed
8. Dollberg, S, Lusky, A, Reichman, B. Patent ductus arteriosus, indomethacin and necrotising enterocolitis in very low brith weight infants: a population-based study. J Pediatr Gastroenterol Nutr 2005; 40: 184–188.Google Scholar
9. McNamara, PJ, Sehgal, A. Towards rational management of the patent ductus arteriosus: the need for disease staging. Arch Dis Child Fetal Neonatal Ed 2007; 92: 424–427.Google Scholar
10. Schmitz, L, Stiller, B, Koch, H, et al. Diastolic left ventricular function in preterm infants with a patent ductus arteriosus: a serial Doppler echocardiography study. Early Human development 2004; 76: 91–100.Google Scholar
11. Negrine, RJS, Chikermane, A, Wright, JGC, Ewer, AK. Assessment of myocardial function in neonates using tissue Doppler imaging. Arch Dis Child Fetal Neonatal ED 2012; 97: F304–F304.CrossRefGoogle ScholarPubMed
12. Ciccone, M, Schcchitano, P, Zito, A, et al. Different functional cardiac characteristics observed in term/preterm neonates by echocardiography and tissue Doppler imaging. Early Human Development 2011; 87: 555–558.Google Scholar
13. El-Khuffash, AF, Jain, A, Dragulescu, A, et al. Acute changes in myocardial systolic function in preterm infants undergoing patent ductus arteriosus ligation. A tissue doppler and myocardial deformation study. J Am Soc Echocardiogr 2012; 25: 1058–1067.Google Scholar