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Aortic stiffness and flow-mediated dilatation in normotensive offspring of parents with hypertension

Published online by Cambridge University Press:  21 February 2012

Harun Evrengul ,
Halil Tanriverdi ,
Ismail D. Kilic ,
Dursun Dursunoglu ,
Emin E. Ozcan ,
Asuman Kaftan  and
Mustafa Kilic
Harun Evrengul
Affiliation:
Department of Cardiology, Sifa Hospital, Izmir, Turkey
Halil Tanriverdi
Affiliation:
Department of Cardiology, Pamukkale University Faculty of Medicine, Denizli, Turkey
Ismail D. Kilic
Affiliation:
Department of Cardiology, Pamukkale University Faculty of Medicine, Denizli, Turkey
Dursun Dursunoglu
Affiliation:
Department of Cardiology, Pamukkale University Faculty of Medicine, Denizli, Turkey
Emin E. Ozcan*
Affiliation:
Department of Cardiology, Sifa Hospital, Izmir, Turkey
Asuman Kaftan
Affiliation:
Department of Cardiology, Pamukkale University Faculty of Medicine, Denizli, Turkey
Mustafa Kilic
Affiliation:
Department of Cardiology, Pamukkale University Faculty of Medicine, Denizli, Turkey
*
Correspondence to: Dr E. E. Ozcan, Department of Cardiology, Sifa Hospital, Sanayi Caddesi No: 7, 35100 Bornova–Izmir, Turkey. Tel: +90 533 5477268; Fax: +90 232 3435656; E-mail: [email protected]
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Abstract

Objectives

Although hypertension has been shown to be one of the most important risk factors for atherosclerosis, data about the presence of subclinical atherosclerosis in normotensive offspring with parental history of hypertension are scarce. Accordingly, the current study was designated to evaluate flow-mediated dilatation and aortic stiffness, which are early signs of atherosclerosis in young subjects with parental history of hypertension.

Methods

A total of 102 healthy, non-obese subjects in the age group of 18–22 years were included in this study and divided into two groups. The first group included 70 offspring of hypertensive parents and the second group included 70 offspring of normotensive parents as controls. In all subjects, endothelium-dependent and endothelium-independent vasodilatation of the brachial artery and aortic elastic parameters were investigated using high-resolution Doppler echocardiography.

Results

Offspring of hypertensive parents demonstrated higher values of aortic stiffness (7.1 plus or minus 1.88 and 6.42 plus or minus 1.56, respectively) but lower distensibility (9.47 plus or minus 1.33 and 11.8 plus or minus 3.36 square centimetres per dyne per 106) and flow-mediated dilatation (4.57 plus or minus 1.3 versus 6.34 plus or minus 0.83 percent, p equals 0.0001, respectively) than offspring of hypertensive parents.

Conclusion

We observed blunted endothelium-dependent dilatation and aortic stiffness in offspring of hypertensive parents compared with offspring of hypertensive parents. This is evident in the absence of overt hypertension and other diseases, suggesting that parental history of hypertension is a risk for subclinical atherosclerosis and it may contribute to the progression to hypertension and overt atherosclerosis in later life.

Keywords

Hypertensionfamily historynon-invasive indicators of atherosclerosisendothelial function
Type
Original Article
Information
Cardiology in the Young , Volume 22 , Issue 4 , August 2012 , pp. 451 - 456
Copyright
Copyright © Cambridge University Press 2012

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