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An unusual course of anti-Ro antibody-mediated fetal complete heart block

Published online by Cambridge University Press:  07 November 2017

Claudia Renaud ,
Edgar Jaeggi  and
Varsha Thakur
Claudia Renaud
Affiliation:
From the Labatt Family Heart Center, Department of Pediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada
Edgar Jaeggi
Affiliation:
From the Labatt Family Heart Center, Department of Pediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada
Varsha Thakur*
Affiliation:
From the Labatt Family Heart Center, Department of Pediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada
*
Correspondence to: V. Thakur, Labatt Family Heart Center, Department of Pediatrics, The Hospital for Sick Children, 555 University Ave, Toronto, ON, Canada, M5G 1X8. Tel: +1 416 779 4752. E-mail: [email protected]
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Abstract

Fetal hydrops is a serious complication of immune-mediated congenital complete atrioventricular block. We present the case of a fetus with severe hydrops and profound bradycardia and an unusual favourable outcome. This case enhances the importance of considering the contribution of ventricular ectopic beats to the cardiac output when counselling and predicting outcome of complete heart block.

Keywords

Complete heart blockanti-Ro antibodiesfetalhydropsventricular ectopy
Type
Brief Report
Information
Cardiology in the Young , Volume 28 , Issue 1 , January 2018 , pp. 171 - 174
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Copyright
© Cambridge University Press 2017 

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References

1. Brucato, A, Cimaz, R, Caporali, R, et al. Pregnancy outcomes in patients with autoimmune diseases and anti-Ro/SSA antibodies. Clin Rev Allergy Immunol 2011; 40: 27–41.CrossRefGoogle ScholarPubMed
2. Gladman, G, Silverman, ED, Yuk, L, et al. Fetal echocardiographic screening of pregnancies of mothers with anti-Ro and/or anti-La antibodies. Am J Perinatol 2002; 19: 73–80.CrossRefGoogle ScholarPubMed
3. Jaeggi, ET, Fouron, JC, Silverman, ED, et al. Transplacental fetal treatment improves the outcome of prenatally diagnosed complete atrioventricular block without structural heart disease. Circulation 2004; 110: 1542–1548.CrossRefGoogle ScholarPubMed
4. Hutter, D, Silverman, ED, Jaeggi, ET. The benefits of transplacental treatment of isolated congenital complete heart block associated with maternal anti-Ro/SSA antibodies: a review. Scand J Immunol 2010; 72: 235–241.CrossRefGoogle ScholarPubMed
5. Jaeggi, E, Laskin, C, Hamilton, R, et al. The importance of the level of maternal anti-Ro/SSA antibodies as a prognostic marker of the development of cardiac neonatal lupus erythematosus a prospective study of 186 antibody-exposed fetuses and infants. J Am Coll Cardiol 2010; 55: 2778–2784.CrossRefGoogle ScholarPubMed
6. Jaeggi, ET, Hamilton, RM, Silverman, ED, et al. Outcome of children with fetal, neonatal or childhood diagnosis of isolated congenital atrioventricular block. A single institution’s experience of 30 years. J Am Coll Cardiol 2002; 39: 130–137.CrossRefGoogle ScholarPubMed
7. Groves, AM, Allan, LD, Rosenthal, E. Therapeutic trial of sympathomimetics in three cases of complete heart block in the fetus. Circulation 1995; 92: 3394–3396.CrossRefGoogle ScholarPubMed
8. Eliasson, H, Sonesson, SE, Sharland, G, et al. Isolated atrioventricular block in the fetus: a retrospective, multinational, multicenter study of 175 patients. Circulation 2011; 124: 1919–1926.CrossRefGoogle ScholarPubMed
9. Chockalingam, P, Jaeggi, ET, Rammeloo, LA, et al. Persistent fetal sinus bradycardia associated with maternal anti-SSA/Ro and anti-SSB/La antibodies. J Rheumatol 2011; 38: 2682–2685.CrossRefGoogle ScholarPubMed
10. Wakisaka, Y, Niwano, S, Niwano, H, et al. Structural and electrical ventricular remodeling in rat acute myocarditis and subsequent heart failure. Cardiovasc Res 2004; 63: 689–699.CrossRefGoogle ScholarPubMed
11. Lopes, LM, Tavares, GM, Damiano, AP, et al. Perinatal outcome of fetal atrioventricular block: one-hundred-sixteen cases from a single institution. Circulation 2008; 118: 1268–1275.CrossRefGoogle ScholarPubMed
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