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Adverse events within 1 year after surgical and percutaneous closure of atrial septal defects in preterm children

Published online by Cambridge University Press:  04 June 2019

Gustaf Tanghöj Open the ORCID record for Gustaf Tanghöj [Opens in a new window] ,
Petru Liuba ,
Gunnar Sjöberg ,
Annika Rydberg  and
Estelle Naumburg
Gustaf Tanghöj*
Affiliation:
Department of Clinical Sciences, Unit of Paediatrics, Umeå University, Umeå, Sweden
Petru Liuba
Affiliation:
Department of Cardiology, Paediatric Heart Centre, Skåne University Hospital Lund, Lund, Sweden
Gunnar Sjöberg
Affiliation:
Department of Women’s and Children’s Health, Karolinska Institute, Stockholm, Sweden
Annika Rydberg
Affiliation:
Department of Clinical Sciences, Unit of Paediatrics, Umeå University, Umeå, Sweden
Estelle Naumburg
Affiliation:
Department of Clinical Sciences, Unit of Paediatrics, Umeå University, Umeå, Sweden
*
Author for correspondence: Gustaf Tanghöj, PhD student, Barnkliniken Östersunds Sjukhus, 831 82 Östersund, Sweden. Tel: +46 (0)63 153000; E-mail: [email protected]
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Abstract

Introduction:

Atrial septal defect is the third most common CHD. A hemodynamically significant atrial septal defect causes volume overload of the right side of the heart. Preterm children may suffer from both pulmonary and cardiac comorbidities, including altered myocardial function. The aim of this study was to compare the rate of adverse events following atrial septal defect closure in preterm- and term-born children.

Method:

We performed a retrospective cohort study including children born in Sweden, who had a surgical or percutaneous atrial septal defect closure at the children’s hospitals in Lund and Stockholm, between 2000 and 2014, assessing time to the first event within 1 month or 1 year. We analysed differences in the number of and the time to events between the preterm and term cohort using the Kaplan–Meier survival curve, a generalised model applying zero-inflated Poisson distribution and Gary-Anderson’s method.

Results:

Overall, 413 children were included in the study. Of these, 93 (22.5%) were born prematurely. The total number of adverse events was 178 (110 minor and 68 major). There was no difference between the cohorts in the number of events, whether within 1 month or within a year, between major (p = 0.69) and minor (p = 0.84) events or frequencies of multiple events (p = 0.92).

Conclusion:

Despite earlier procedural age, larger atrial septal defects, and higher comorbidity than term children, preterm children appear to have comparable risk for complications during the first year after surgical or percutaneous closure.

Keywords

Childatrial septal defectpercutaneous closuresurgical closurecomplications
Type
Original Article
Information
Cardiology in the Young , Volume 29 , Issue 5 , May 2019 , pp. 626 - 636
Copyright
© Cambridge University Press 2019 

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