Hostname: page-component-cd9895bd7-dk4vv Total loading time: 0 Render date: 2024-12-23T23:06:01.784Z Has data issue: false hasContentIssue false
  • English
  • Français

Vitamin C deficiency as an unusual cause of pulmonary hypertension and refusal to walk

Published online by Cambridge University Press:  10 December 2020

Jason W. Y. Tan Open the ORCID record for Jason W. Y. Tan [Opens in a new window] ,
Olive P. E. Lee  and
Ming Chern Leong
Jason W. Y. Tan
Affiliation:
Paediatric and Congenital Heart Centre, Institut Jantung Negara (National Heart Institute of Malaysia), Kuala Lumpur, Malaysia
Olive P. E. Lee
Affiliation:
Paediatric and Congenital Heart Centre, Institut Jantung Negara (National Heart Institute of Malaysia), Kuala Lumpur, Malaysia
Ming Chern Leong*
Affiliation:
Paediatric and Congenital Heart Centre, Institut Jantung Negara (National Heart Institute of Malaysia), Kuala Lumpur, Malaysia
*
Author for correspondence: Dr M. C. Leong, Consultant Paediatric Cardiologist, Paediatric and Congenital Heart Centre, Institut Jantung Negara (National Heart Institute of Malaysia), 145, Jalan Tun Razak, Kuala Lumpur50400, Malaysia. Tel: +603-26178470; Fax: +603 – 2694 6478. E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Vitamin C deficiency has been a historical disease rarely seen nowadays. We illustrate a case of a boy with autism presenting with severe pulmonary hypertension and refusal to walk secondary to vitamin C deficiency. Initiating treatment with high-dose vitamin C reversed his symptoms and he regained full power of his lower limbs with total normalisation of his pulmonary pressures.

Keywords

Pulmonary hypertensionvitamin C deficiencyautistic spectrum disorder
Type
Brief Report
Information
Cardiology in the Young , Volume 31 , Issue 2 , February 2021 , pp. 322 - 324
Check for updates
Copyright
© The Author(s), 2020. Published by Cambridge University Press

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Ratanachu-Ek, S, Sukswai, P, Jeerathanyasakun, Y, Wongtapradit, L. Scurvy in pediatric patients: a review of 28 cases. J Med Assoc Thai 2003; 86 (Suppl 3): S734–S740.Google ScholarPubMed
Lund, RM, Becker, ML, Shapiro, S, Allison, T, Harris, JG. Scurvy presenting with limp and weakness: a case report. BMC Pediatr 2019; 19: 228.CrossRefGoogle ScholarPubMed
DePhillipo, NN, Aman, ZS, Kennedy, MI, Begley, JP, Moatshe, G, LaPrade, RF. Efficacy of vitamin C supplementation on collagen synthesis and oxidative stress after musculoskeletal injuries: a systematic review. Orthop J Sports Med 2018; 6: 2325967118804544.CrossRefGoogle ScholarPubMed
Weinstein, M, Babyn, P, Ziotkin, S. An orange a day keeps the doctor away: scurvy in the year 2000. Pediatrics 2001; 108: E55.CrossRefGoogle Scholar
Kupari, M, Rapola, J. Reversible pulmonary hypertension associated with vitamin C deficiency. Chest 2012; 142: 225–227.CrossRefGoogle ScholarPubMed
Duvall, MG, Pikman, Y, Kantor, DB, et al. Pulmonary hypertension associated with scurvy and vitamin deficiencies in an autistic child. Pediatrics 2013; 132: e1699–e1703.CrossRefGoogle Scholar
Wong, CM, Bansal, G, Pavlickova, L, Marcocci, L, Suzuki, YJ. Reactive oxygen species and antioxidants in pulmonary hypertension. Antioxid Redox Signal 2013; 18: 1789–1796.CrossRefGoogle ScholarPubMed
Ali, SG, Pepi, M. A very uncommon case of pulmonary hypertension. CASE 2018; 2: 279–281.Google Scholar
Dean, T, Kaushik, N, William, S, Zinter, M, Kim, P. Cardiac arrest and pulmonary hypertension in scurvy: a case report. Pulm Circ 2019; 9: 2045894018812052.CrossRefGoogle ScholarPubMed
Ichiyanagi, S, Takeshita, I, Kandil, AI, Miyazu, M, Kojima, T. Pulmonary hypertensive crisis during general anesthesia in a 3-year-old autistic boy with undiagnosed scurvy, undergoing cardiac catheterization: a case report. A A Pract 2019; 13: 379–381.CrossRefGoogle Scholar