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Successful treatment of disseminated adenovirus infection with cidofovir and intravenous immunoglobulin in an infant following heart transplant

Part of: Infectious

Published online by Cambridge University Press:  25 April 2018

Ryan M. Serrano ,
Robert K. Darragh  and
John J. Parent
Ryan M. Serrano*
Affiliation:
Pediatric Cardiology, Riley Hospital for Children, Indianapolis, IN, USA
Robert K. Darragh
Affiliation:
Pediatric Cardiology, Riley Hospital for Children, Indianapolis, IN, USA
John J. Parent
Affiliation:
Pediatric Cardiology, Riley Hospital for Children, Indianapolis, IN, USA
*
Author for correspondence: R. M. Serrano, Pediatric Cardiology, 705 Riley Hospital Drive, RR 127, Indianapolis, IN 46202, USA. Tel: +317 274 8906; Fax: +317 274 4022; E-mail: [email protected]
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Abstract

For most patients, adenoviruses cause few acute health concerns and are often self-limiting. Patients who are immunocompromised or immunosuppressed, however, are at risk for disseminated adenovirus and suffer high morbidity and mortality, without well-defined treatment options. We report the case of a 9-month-old boy who was successfully treated for disseminated adenovirus infection with intravenous immunoglobulin and cidofovir 3 months post heart transplant, tailored to serum adenoviral load and clinical response. We emphasise the importance of early identification, monitoring, and a potentially novel treatment in the paediatric cardiac transplant population with disseminated adenovirus infection.

Keywords

Cardiac transplantationadenovirusIVIG
Type
Brief Report
Information
Cardiology in the Young , Volume 28 , Issue 6 , June 2018 , pp. 888 - 889
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Copyright
© Cambridge University Press 2018 

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References

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