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Spontaneous closure of muscular ventricular septal defect identified by echocardiography in neonates

Published online by Cambridge University Press:  19 August 2008

Zhong-Dong Du ,
Nathan Roguin  and
Xing-Jian Wu
Zhong-Dong Du*
Affiliation:
Heart Institute, Western Galilee Hospital-Nahariya, Technion Faculty of Medicine, Israel
Nathan Roguin
Affiliation:
Heart Institute, Western Galilee Hospital-Nahariya, Technion Faculty of Medicine, Israel
Xing-Jian Wu
Affiliation:
Heart Institute, Western Galilee Hospital-Nahariya, Technion Faculty of Medicine, Israel
*
Present address and address for reprints: Dr. Zhong-Dong Du, Division of Cardiology, Capital Institute of Pediatrics, No. 2, Ya Bao Road, 100020 Beijing, China. Tel: 86-10-8032086; Fax: 86-10-5128367
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Abstract

Muscular ventricular septal defects were diagnosed by echocardiography in 97 neonates within 7 days of birth. In 82 of the neonates (84.5%), the defect was solitary, while 15 had multiple defects. The solitary defects was located at mid-septal, apical, anterior and inlet locations in 42 (51.2%), 21 (25.6%), 14 (17.1%) and 5 (6.1%) neonates, respectively. Multiple defects occurred in the apical, anterior and mid-septal areas. The diameter of the solitary defects ranged from 1 to 6 mm (2.3 ± 0.8 mm), while the multiple lesions were 1 to 4 mm in diameter (2.1 2.3 ± 0.8 mm 0.8 mm) in 28 instances in which they could measured. It proved possible to follow 79 of the patients for period of 10 to 13 months. The defects closed spontaneously in 56 (84.8%) of 66 patients with a single defect, and in 7 (53.8%) of 13 of those with multiple defects (P<0.05). For the solitary defects, the position and size were factors determining the likelihood and speed of closure. Defects located at the apical septum, or defects larger than 4 mm in diameter, closed slowly and at a later stage. Echocardiography is an useful technique in establishing of natural history of muscular ventricular septal defects encountered in neonates.

Keywords

Muscular ventricular septal defectspontaneous closureneonate
Type
Original Articles
Information
Cardiology in the Young , Volume 8 , Issue 4 , October 1998 , pp. 500 - 505
Copyright
Copyright © Cambridge University Press 1998

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