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Salusin-α levels are negatively correlated with diastolic blood pressure in children with obesity

Published online by Cambridge University Press:  05 September 2019

Pınar Dervişoğlu ,
Bahri Elmas ,
Mustafa Kösecik ,
Şükriye P. İşgüven ,
Mustafa Büyükavcı  and
Mehmet Köroğlu
Pınar Dervişoğlu*
Affiliation:
Department of Pediatric Cardiology, Sakarya University Training and Research Hospital, Sakarya, Turkey
Bahri Elmas
Affiliation:
Clinic of Pediatric, Sakarya University Training and Research Hospital, Sakarya, Turkey
Mustafa Kösecik
Affiliation:
Department of Pediatric Cardiology, Uludag University Faculty of Medicine, Bursa, Turkey
Şükriye P. İşgüven
Affiliation:
Department of Pediatric Endocrinology, Sakarya University Training and Research Hospital, Sakarya, Turkey
Mustafa Büyükavcı
Affiliation:
Department of Pediatric Hematology, Sakarya University Training and Research Hospital, Sakarya, Turkey
Mehmet Köroğlu
Affiliation:
Department of Medical Microbiology, Sakarya University Training and Research Hospital, Sakarya, Turkey
*
Address for correspondence: P. Dervişoğlu, Sakarya University Training and Research Hospital, Department of Pediatric Cardiology, Sakarya 54100, Turkey. Tel: +090-505-9231960; E-mail: [email protected]
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Abstract

Salusins have emerged as a new biomarker that reflects an increased inflammatory state, which is associated with cardiovascular risk. We investigated the predictive value and usefulness of salusins as an inflammatory biomarker in obese children. This prospective cohort study included 75 obese children and 101 healthy children (as a control group). Salusin-α, Salusin-β, and various cardiovascular parameters were assessed in both groups. Correlation analyses of Salusin-α and Salusin-β with body mass index standard deviation scores and inflammatory and cardiovascular markers were performed. The mean patient age was 11.9±2.4 years for the obese group and 12.5±2.1 years for the control group. The obese children had a significantly higher heart rate, systolic blood pressure, diastolic blood pressure, epicardial adipose tissue thickness, and left ventricular mass than did the children in the control group. There was no significant correlation between Salusin-α and Salusin-β and body mass index; however, there was a negative correlation between Salusin- α and diastolic blood pressure (r = 0.277, p = 0.004). Overall, there was no significant difference in the Salusin-α and Salusin-β levels between obese and healthy children. However, a negative correlation was found between Salusin-α and diastolic blood pressure. Although this result suggests that Salusin-α might be an early marker of cardiovascular involvement in obese children, further studies are needed to demonstrate the predictive value of salusins.

Keywords

Salusinsobesitychildhoodatherosclerosisdiastolic blood pressure
Type
Original Article
Information
Cardiology in the Young , Volume 29 , Issue 10 , October 2019 , pp. 1225 - 1229
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Copyright
© Cambridge University Press 2019 

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References

Vos, MB, Welsh, J. Childhood obesity: update on predisposing factors and prevention strategies. Curr Gastroenterol Rep 2010; 12: 280–287.CrossRefGoogle ScholarPubMed
Llewellyn, A, Simmonds, M, Owen, CG, Woolacott, N. Childhood obesity as a predictor of morbidity in adulthood: a systematic review and meta-analysis. Obes Rev 2016; 17: 56–67.CrossRefGoogle ScholarPubMed
Manduteanu, I, Simionescu, M. Inflammation in atherosclerosis: a cause or a result of vascular disorders. J Cell Mol Med 2012; 16: 1978–1990.CrossRefGoogle ScholarPubMed
Zimmermann, MB, Aeberli, I. Dietary determinants of subclinical inflammation, dyslipidemia and components of the metabolic syndrome in overweight children: a review. Int J Obes (Lond) 2008; 32: S11–S18.CrossRefGoogle ScholarPubMed
de Ferranti, S, Mozaffarian, D. The perfect storm: obesity, adipocyte dysfunction, and metabolic consequences. Clin Chem 2008; 54: 945–955. doi: 10.1373/clinchem.2007.100156 CrossRefGoogle ScholarPubMed
Bahadır, A, Baltacı, D, Türker, Y, et al. Is the neutrophil-tolymphocyte ratio indicative of inflammatory state in patients with obesity and metabolic syndrome? Anatol J Cardiol 2015; 15: 816–822.CrossRefGoogle Scholar
Inzaugarat, ME, Billordo, LA, Vodánovich, F, Cervini, GM, Casavalle, PL, Vedire, C. Alterations in innate and adaptive immune leukocytes are involved in paediatric obesity. Pediatr Obes 2014; 9: 381–390.CrossRefGoogle ScholarPubMed
Abaci, A, Tascilar, ME, Saritas, T, Yozgat, Y, Yesilkaya, E, Kilic, A. Threshold value of subepicardial adipose tissue to detect insulin resistance in obese children. Int J Obes (Lond) 2009; 33: 440–446. doi: 10.1038/ijo.2009.1 CrossRefGoogle ScholarPubMed
Rabkin, SW. Epicardial fat: properties, function and relationship to obesity. Obes Rev 2007; 8: 253–261.CrossRefGoogle ScholarPubMed
Lamotte, C, Iliescu, C, Libersa, C, Gottrand, F. Increased intima-media thickness of the carotid artery in childhood: a systematic review of observational studies. Eur J Pediatr 2011; 170: 719–729. doi: 10.1007/s00431-010-1328-y CrossRefGoogle ScholarPubMed
Shichiri, M, Ishimaru, S, Ota, T, Nishikawa, T, Isogai, T, Hirata, Y. Salusins: newly identified bioactive peptides with hemodynamic and mitogenic activities. Nat Med 2003; 9: 1166–1172.CrossRefGoogle ScholarPubMed
Suzuki, N, Shichiri, M, Akashi, T, Sato, K, Sakurada, M, Hirono, Y. Systemic distribution of salusin expression in the rat. Hypertens Res 2007; 30: 1255–1262.CrossRefGoogle ScholarPubMed
Sato, K, Watanabe, R, Itoh, F. Salusins: potential use as a biomarker for atherosclerotic cardiovascular diseases. Int J Hypertension 2013; 2013: 965140.CrossRefGoogle ScholarPubMed
Watanabe, T, Nishio, K, Kanome, T, et al. Impact of salusin-α and-β on human macrophage foam cell formation and coronary atherosclerosis. Circulation 2008; 117: 638–648.CrossRefGoogle ScholarPubMed
Miyazaki, A, Sakashita, N, Lee, O, et al. Expression of ACAT-1 protein in human atherosclerotic lesions and cultured human monocytes-macrophages. Arterioscler Thromb Vasc Biol 1998; 18: 1568–1574.CrossRefGoogle ScholarPubMed
Suguro, T, Watanabe, T, Kanome, T, et al. Serotonin acts as an up-regulator of acyl-coenzyme A:cholesterol acyltransferase-1 in human monocyte-macrophages. Atherosclerosis 2006; 186: 275–281.CrossRefGoogle ScholarPubMed
Yu, F, Zhao, J, Yang, J, et al. Salusins promote cardiomyocyte growth but does not affect cardiac function in rats. Regul Pept 2004; 122: 191–197.CrossRefGoogle Scholar
Bundak, R, Furman, A, Gunoz, H, Darendeliler, F, Bas, F, Neyzi, O. Body mass index references for Turkish children. Acta Paediatr 2006; 95: 194–198.CrossRefGoogle ScholarPubMed
Cole, TJ, Bellizzi, MC, Flegal, KM, Dietz, WH. Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ 2000; 320: 1240–1243.CrossRefGoogle ScholarPubMed
Daniels, SR, Kimball, TR, Morrison, JA, Khoury, P, Meyer, RA. Indexing left ventricular mass to account for differences in body size in children and adolescents without cardiovascular disease. Am J Cardio 1995; 76: 699–701.CrossRefGoogle ScholarPubMed
Lang, RM, Bierig, M, Devereux, RB, et al. Recommendations for chamber quantification: a report from the American Society of Echocardiography’s Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology. J Am Soc Echocardiogr 2005; 18: 1440–1463.CrossRefGoogle ScholarPubMed
Iacobellis, G, Ribaudo, MC, Zappaterreno, A, Iannucci, CV, Leonetti, F. Relation between epicardial adipose tissue and left ventricular mass. Am J Cardiol 2004; 94: 1084–1087.CrossRefGoogle ScholarPubMed
Ogden, CL, Carroll, MD, Lawman, HG, et al. Trends in obesity prevalence among children and adolescents in the United States, 1988–1994 through 2013–2014. JAMA 2016; 315: 2292–2299.CrossRefGoogle ScholarPubMed
Burke, V. Obesity in childhood and cardiovascular risk. Clin Exp Pharmacol Physiol 2006; 33: 831–837.CrossRefGoogle ScholarPubMed
Wildman, RP, McGinn, AP, Lin, J, Wang, D, Muntner, P, Cohen, HW. Cardiovascular disease risk of abdominal obesity vs. metabolic abnormalities. Obesity (Silver Spring) 2011; 19: 853–860.CrossRefGoogle ScholarPubMed
Tam, CS, Clément, K, Baur, LA, Tordjman, J. Obesity and low-grade inflammation: a pediatric perspective. Obes Rev 2010; 11: 118–126.CrossRefGoogle Scholar
Ferroni, P, Basili, S, Fako, A, Davi, G. Inflammation, insulin resistance and obesity. Curr Atheroscler Rep 2004; 6: 424–31.CrossRefGoogle ScholarPubMed
Nagashima, M, Watanabe, T, Shiraishi, Y. Chronic infusion of salusin-alpha and -beta exerts opposite effects on atherosclerotic lesion development in apolipoprotein E deficient mice. Atherosclerosis 2010; 212: 70–77.CrossRefGoogle ScholarPubMed
Kołakowska, U, Kuroczycka-Saniutycz, E, Wasilewska, A, Olański, W. Is the serum level of salusin-β associated with hypertension and atherosclerosis in the pediatric population? Pediatr Nephrol 2015; 30: 523–531. doi: 10.1007/s00467-014-2960-y CrossRefGoogle ScholarPubMed
Fujimoto, K, Hayashi, A, Kamata, Y, et al. Circulating levels of human salusin-β, a potent hemodynamic and atherogenesis regulator. PLoS One 2013; 8: e76714. doi: 10.1371/journal.pone.0076714 CrossRefGoogle ScholarPubMed
Liu, J, Ren, YG, Zhang, LH, Tong, YW, Kang, L. Serum salusin-β levels are associated with the presence and severity of coronary artery disease. J Investig Med 2015; 63: 632–635. doi: 10.1097/JIM.0000000000000184.CrossRefGoogle ScholarPubMed
Du, SL, Wang, WJ, Wan, J, Wang, YG, Wang, ZK, Zhang, Z. Serum salusin-α levels are inversely correlated with the presence and severity of coronary artery disease. Scand J Clin Lab Invest 2013; 73: 339–343. doi: 10.3109/00365513.2013.783227 CrossRefGoogle ScholarPubMed
Lakka, TA, Lakka, HM, Salonen, R, Kaplan, GA, Salonen, JT. Abdominal obesity is associated with accelerated progression of carotid atherosclerosis in men. Atherosclerosis 2001; 154: 497–504.CrossRefGoogle ScholarPubMed
De Michele, M, Panico, S, Iannuzzi, A, Celentana, E, Ciardullo, AV. Association of obesity and central fat distribution with carotid artery wall thickening in middle-aged women. Stroke 2002; 33: 2923–2928.CrossRefGoogle ScholarPubMed
Wheeler, GL, Shi, R, Beck, SR, et al. Pericardial and visceral adipose tissues measured volumetrically with computed tomography are highly associated in type 2 diabetic families. Invest Radiol 2005; 40: 97e101.CrossRefGoogle ScholarPubMed
Iacobellis, G, Assael, F, Ribaudo, MC. Epicardial fat from echocardiography: a new method for visceral adipose tissue prediction. Obes Res 2003; 11: 304e310.CrossRefGoogle ScholarPubMed
Chistiakov, DA, Grechko, AV, Myasoedova, VA, Melnichenko, AA, Orekhov, AN. Impact of the cardiovascular system-associated adipose tissue on atherosclerotic pathology. Atherosclerosis 2017; 263: 361–368.CrossRefGoogle ScholarPubMed
Robinson, RF, Batisky, DL, Hayes, JR, Nahata, MC, Mahan, JD. Body mass index in primary and secondary pediatric hypertension. Pediatr Nephrol 2004; 19: 1379–1384.CrossRefGoogle ScholarPubMed
Flynn, JT, Alderman, MH. Characteristics of children with primary hypertension seen at a referral center. Pediatr Nephrol 2005; 20: 961–966.CrossRefGoogle ScholarPubMed
Kannel, WB, Gordon, T, Schwartz, MJ. Systolic versus diastolic blood pressure and risk of coronary heart disease. Am J Cardiol 1971; 27: 335–346.CrossRefGoogle ScholarPubMed
Lichtenstein, MJ, Shipley, MJ, Rose, G. Systolic and diastolic blood pressures as predictors of coronary heart disease mortality in the Whitehall study. BMJ 1985; 291: 243–245.CrossRefGoogle ScholarPubMed
Franklin, SS, Larson, MG, Khan, SA, et al. Does the relation of blood pressure to coronary heart disease risk change with aging? The Framingham heart study. Circulation 2001; 103: 1245–1249.CrossRefGoogle ScholarPubMed
Pickering, TG. Isolated diastolic hypertension. J Clin Hypertens 2003; 5: 411–413.CrossRefGoogle ScholarPubMed
Ti, Y, Wang, F, Wang, ZH, et al . Associations of serum salusin-alpha levels with atherosclerosis and left ventricular diastolic dysfunction in essential hypertension. J Hum Hypertens 2012; 26: 603–609.CrossRefGoogle ScholarPubMed