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Phentolamine improves clinical outcome after balloon valvoplasty in neonates with severe pulmonary stenosis

Published online by Cambridge University Press:  19 August 2008

Omar Galal ,
Avedis Kalloghlian ,
Babu M. Pittappilly  and
Nduna Dzimiri
Omar Galal*
Affiliation:
Department of Cardiovascular Diseases, King Faisal Specialist Hospital & Research Center, PO Box 3354, Riyadh 11211, Saudi Arabia
Avedis Kalloghlian
Affiliation:
Department of Cardiovascular Diseases, King Faisal Specialist Hospital & Research Center, PO Box 3354, Riyadh 11211, Saudi Arabia
Babu M. Pittappilly
Affiliation:
Department of Cardiovascular Diseases, King Faisal Specialist Hospital & Research Center, PO Box 3354, Riyadh 11211, Saudi Arabia
Nduna Dzimiri
Affiliation:
Biological and Medical Research Department, King Faisal Specialist Hospital & Research Center, PO Box 3354, Riyadh 11211, Saudi Arabia
*
Moh. Omar Galal, MD, PH.D., Cardiovascular Department, MBC 16, King Faisal Specialist Hospital and RC, PO BOX 3354, Riyadh 11211, Saudi Arabia. Tel: 996-1-4647272; Fax: 009661-1-4427482
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Abstract

Two neonates with severe pulmonary stenosis deteriorated immediately after successful balloon valvoplasty as a result of increased infundibular obstruction. They were treated with β-adrenoceptor blockers and intravascular expansion with limited success. Phentolamine was then given, resulting in dramatic improvement. The children could be weaned from the ventilator within hours of starting this new therapeutic modality.

Keywords

Phentolaminesevere pulmonary stenosisballoon valvoplasty
Type
Original Articles
Information
Cardiology in the Young , Volume 9 , Issue 2 , March 1999 , pp. 127 - 128
Copyright
Copyright © Cambridge University Press 1999

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References

1.Ben–Shachar, G, Cohen, MH, Sivakoff, Mc, Portman, MA, Riemenschneider, TA, Van Heeckeren, DW. Development of infundibular obstruction after percutaneous pulmonary balloon valvuloplasty. J Am Coll Cardiol 1985: 5; 754–756.Google Scholar
2.Galal, O, Dzimiri, N, Moorji, A, Bakr, S, Almotrefi, AA. Sympathetic activity in children undergoing balloon vavuloplasty of pulmonary stenosis. Pediatr Res 1996; 39: 774–778.CrossRefGoogle Scholar