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Palivizumab compliance in congenital heart disease patients: factors related to compliance and altered lower respiratory tract infection viruses after palivizumab prophylaxis

Published online by Cambridge University Press:  19 May 2020

Kutay Sel Open the ORCID record for Kutay Sel [Opens in a new window] ,
Ebru Aypar Open the ORCID record for Ebru Aypar [Opens in a new window] ,
Yasemin Nuran Dönmez ,
Emil Aliyev ,
Hakan Hayrettin Aykan Open the ORCID record for Hakan Hayrettin Aykan [Opens in a new window] ,
Tevfik Karagöz  and
Dursun Alehan
Kutay Sel*
Affiliation:
Department of Pediatric Cardiology, Ihsan Doğramacı Children’s Hospital, Hacettepe University Faculty of Medicine, Ankara, Turkey
Ebru Aypar
Affiliation:
Department of Pediatric Cardiology, Ihsan Doğramacı Children’s Hospital, Hacettepe University Faculty of Medicine, Ankara, Turkey
Yasemin Nuran Dönmez
Affiliation:
Department of Pediatric Cardiology, Ihsan Doğramacı Children’s Hospital, Hacettepe University Faculty of Medicine, Ankara, Turkey
Emil Aliyev
Affiliation:
Department of Pediatric Cardiology, Ihsan Doğramacı Children’s Hospital, Hacettepe University Faculty of Medicine, Ankara, Turkey
Hakan Hayrettin Aykan
Affiliation:
Department of Pediatric Cardiology, Ihsan Doğramacı Children’s Hospital, Hacettepe University Faculty of Medicine, Ankara, Turkey
Tevfik Karagöz
Affiliation:
Department of Pediatric Cardiology, Ihsan Doğramacı Children’s Hospital, Hacettepe University Faculty of Medicine, Ankara, Turkey
Dursun Alehan
Affiliation:
Department of Pediatric Cardiology, Ihsan Doğramacı Children’s Hospital, Hacettepe University Faculty of Medicine, Ankara, Turkey
*
Author for correspondence: Kutay Sel, Department of Pediatric Cardiology, Hacettepe University Faculty of Medicine, Ihsan Doğramacı Childrens Hospital, 06100, Samanpazari, Ankara, Turkey. Tel: +90 312 3051157; Fax: +90 312 3090220; E-mail: [email protected]
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Abstract

Background:

Lower respiratory tract infections caused by respiratory syncytial virus can be severe during infancy, which requires admission to the hospital. These infections may be more severe especially in patients with congenital heart disease. Passive immunisation with palivizumab, a monoclonal antibody, is recommended in high-risk infants. We tried to determine the compliance rates, factors affecting compliance, and also other microorganisms responsible for lower respiratory tract infections after palivizumab prophylaxis in these patients.

Methods:

We evaluated patients’ compliance to prophylaxis with palivizumab in two consecutive respiratory syncytial virus seasons from pharmacy records. We also investigated factors affecting compliance and the frequency of hospitalisations for lower respiratory tract infections. We investigated the causative microorganisms detected in hospitalised patients.

Results:

In this study, 86.7% of the desired number of injections was achieved in 176 patients in two seasons. Out of these, 117 patients (66.4%) received all the doses they were prescribed. Although not statistically significant, compliance to prophylaxis was higher in male patients, cyanotic patients, those who started under 1 year old, and who lived in the city centre. Human metapneumovirus, parainfluenza type 3, and bocavirus were detected in the hospitalised patients.

Conclusion:

Patients with congenital heart disease can survive the period of infancy with less problem by making palivizumab prophylaxis more effective, and awareness about non- respiratory syncytial virus factors may be a guide for the development of new treatments.

Keywords

Congenital heart diseaserespiratory syncytial viruspalivizumab
Type
Original Article
Information
Cardiology in the Young , Volume 30 , Issue 6 , June 2020 , pp. 818 - 821
Copyright
© The Author(s), 2020. Published by Cambridge University Press

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