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P wave dispersion and ventricular repolarization changes in children with familial hypercholesterolemia

Published online by Cambridge University Press:  09 November 2020

Nafiye E. Çakar  and
Ahmet İrdem
Nafiye E. Çakar*
Affiliation:
University of Health Sciences, Okmeydanı Training and Research Hospital, Department of Pediatric Metabolism, Istanbul, Turkey
Ahmet İrdem
Affiliation:
University of Health Sciences, Okmeydanı Training and Research Hospital, Department of Pediatric Cardiology, Istanbul, Turkey
*
Author for correspondence: Nafiye Emel Çakar, Okmeydanı Training and Research Hospital, Pediatric Metabolism Department, Kaptan Paşa Mahallesi, Darülaceze Cad. No:25, 34384 Okmeydanı, Istanbul, Turkey. Tel: +90 505 2702923. E-mail: [email protected]
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Abstract

Background:

Familial hypercholesterolemia is a genetic disease with plasma total cholesterol especially low-density lipoprotein-cholesterol elevation. In this study, we aimed to examine the changes in the electrocardiographies of children with familial hypercholesterolemia.

Materials and methods:

Electrocardiography of 85 patients with a diagnosis of familial hypercholesterolemia, followed up from the Pediatric Metabolism and Pediatric Cardiology outpatient clinic was examined. Electrocardiography of 83 children from the control group who did not have hypercholesterolemia in a similar gender and age range were examined. Heart rate, P wave, PR interval, P wave dispersion, QRS wave, QT interval, corrected QT (calculated with Bazett formula), Tpeak-end interval, QT dispersion, corrected QT dispersion, JT interval, corrected JT (calculated with Bazett formula) were statistically compared.

Results:

P wave, PR interval, and P wave dispersion values were significantly higher (p < 0.05) in the children with familial hypercholesterolemia. Corrected QT, QT dispersion, corrected QT dispersion, JT interval, corrected JT, Tpeak-end interval were significantly higher than the control group (p < 0.05) in children with familial hypercholesterolemia. These statistical differences in electrocardiography parameters support the risk of atrial and/or ventricular arrhythmia in children with familial hypercholesterolemia.

Conclusion:

We found that high total cholesterol and low-density lipoprotein-cholesterol variables are associated with an increased risk of cardiac atrial and/or ventricular arrhythmia. The findings suggest that total cholesterol and low-density lipoprotein-cholesterol variability can be used as a new marker for the risk of cardiac arrhythmia. In this case, decreasing total cholesterol and low-density lipoprotein-cholesterol variability below certain thresholds may decrease the risk of cardiac arrhythmia.

Keywords

hypercholesterolemiaarrhythmiaP wave dispersionventricular repolarisation
Type
Original Article
Information
Cardiology in the Young , Volume 30 , Issue 11 , November 2020 , pp. 1643 - 1648
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Copyright
© The Author(s), 2020. Published by Cambridge University Press

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