Hostname: page-component-586b7cd67f-vdxz6 Total loading time: 0 Render date: 2024-11-26T18:07:04.014Z Has data issue: false hasContentIssue false
  • English
  • Français

Is there any relationship between platelet indices and myocarditis in children?

Part of: Infectious

Published online by Cambridge University Press:  10 May 2021

Damla Geçkalan Soysal Open the ORCID record for Damla Geçkalan Soysal [Opens in a new window]  and
Rahmi Özdemir
Damla Geçkalan Soysal*
Affiliation:
Kütahya Health Sciences University, Department of Pediatrics, Kütahya, Turkey
Rahmi Özdemir
Affiliation:
Kütahya Health Sciences University, Department of Pediatric Cardiology, Kütahya, Turkey
*
Author for correspondence: Damla Geçkalan Soysal, MD, Department of Pediatrics, Kutahya Health Sciences University Faculty of Medicine, Evliya Çelebi Campus on Tavşanlı Road 10.km Kutahya, Turkey. Tel:+90-50628443654. E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Background:

Platelet indices are used to evaluate platelet activation and function which change in inflammatory diseases. We hypothesise that platelet indices such as plateletcrit, mean platelet volume, and platelet distribution width may be more useful as prognostic indicators for myopericarditis in children.

Methods:

A total of 60 children were included in this study. Group 1 consists of children with myopericarditis, Group 2 is those with respiratory infections, and Group 3 consists of control group children of similar age and gender with the patient groups. Complete blood count parameters, C-reactive protein, and troponin values of the whole study group were recorded. Myopericarditis was diagnosed based on acute chest pain, dyspnea, palpitations, heart failure signs, arrhythmia symptoms and ST/T wave change, low voltage, supraventricular tachycardia/ventricular tachycardia on ECG, or elevated troponin T/troponin I levels or functional abnormalities on echocardiography. A comparison of the platelet indices made during diagnosis and 2 weeks after treatment was done for the myopericarditis patients.

Results:

There was no statistically significant difference in platelet indicies values. However, the increase in platelets and plateletcrit values after the treatment of myopericarditis was statistically significant. This study pointed out that there was a negative correlation between platelet–plateletcrit values and the troponin I–C-reactive protein.

Conclusion:

We found that platelet count and plateletcrit values increased after treatment. This is important as it is the first study in children to investigate the possible role of platelet indications for myopericarditis in children.

Keywords

Myopericarditsplatelet indiceschildrenplateletcrit
Type
Original Article
Information
Cardiology in the Young , Volume 32 , Issue 2 , February 2022 , pp. 203 - 207
Check for updates
Copyright
© The Author(s), 2021. Published by Cambridge University Press

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Gasparyan, AY, Ayvazyan, L, Mikhailidis, DP et al. Mean platelet volume: A link between thrombosis and inflammation?. Curr Pharm Des 2011; 17: 47–58.CrossRefGoogle ScholarPubMed
Kim, HK, Kim, JE, Ham, CK, Lee, DS et al. Prognostic value of platelet indices as determined by ADVIA 120 in patients suspected of having disseminated intravascular coagulation. Int J Lab Hematol 2008; 30: 117–123.CrossRefGoogle ScholarPubMed
Maluf, CB, Barreto, SM, Vidigal, PG. Standardization and reference intervals of platelet volume indices: insight from the Brazilian longitudinal study of adult health (ELSABRASIL). Platelets 2015; 26: 413–420.CrossRefGoogle Scholar
Bain, BJ, Bates, I. Basic haematological techniques. In: Lewis, SM, Bain, BJ, Bates, I, (eds). Dacie and Lewis practical haematology. 9th edn. Edinburgh: Churchill Livingstone, 2001: 19–46.Google Scholar
Ruixi, L, Fang, G, Junming, H, Qijian, Y. Study on the relationship between mean platelet volume and platelet distribution width with coronary artery lesion in children with Kawasaki disease. Platelets 2012; 23: 11–16.Google Scholar
Ozdemir, R, Karadeniz, C, Doksoz, O et al. Are mean platelet volume and platelet distribution width useful parameters in children with acute rheumatic carditis?. Pediatr Cardiol 2014; 35: 53–56.CrossRefGoogle ScholarPubMed
Oylumlu, M, Yuksel, M, et al. The usefulness of plateletcrit to predict cardiac syndrome X in patients with normal coronary angiogram. Postepy Kardiol Interwencyjnej 2015; 11: 197–201.Google ScholarPubMed
Nkambule, BB, Davison, GM, Ipp, H. The evaluation of platelet indices and markers of inflammation, coagulation and disease progression in treatment-naïve, asymptomatic HIV-infected individuals. Int J Lab Hematol 2015; 37: 450–458.CrossRefGoogle Scholar
Mukker, P, Kiran, S, et al. Platelet indices evaluation in patients with dengue fever. Int J Res Med Sci 2018; 6: 2054–2059.CrossRefGoogle Scholar
Caforio, AL, Pankuweit, S, Arbustini, E, et al. Current state of knowledge on aetiology, diagnosis, management, and therapy of myocarditis: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases. Eur Heart J 2013; 34: 2636–48, 2648a-2648d.Google Scholar
Golwala, ZM, Shah, H, Gupta, N, et al. Mean Platelet Volume, Platelet Distribution Width, Platelet Count and Plateletcrit as predictors of in-hospital paediatric mortality: a case-control Study. Afr Health Sci 2016; 16: 356–362.CrossRefGoogle ScholarPubMed
Zhang, S, Cui, YL, Diao, MY, et al. Use of Platelet Indices for Determining Illness Severity and Predicting Prognosis in Critically Ill Patients. Chin Med J (Engl) 2015; 128: 2012–2018.CrossRefGoogle ScholarPubMed
Purbiya, P, Golwala, ZM, Manchanda, A, et al. Platelet Distribution Width to Platelet Count Ratio as an Index of Severity of Illness. Indian J Pediatr 2018; 85: 10–14.10.1007/s12098-017-2432-zCrossRefGoogle ScholarPubMed
Sezgi, C, Taylan, M, Kaya, H, et al. Alterations in platelet count and mean platelet volume as predictors of patient outcome in the respiratory intensive care unit. Clin Respir J 2015; 9: 403–408.CrossRefGoogle ScholarPubMed
Chu, SG, Becker, RC, Berger, PB, et al. Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-analysis. J Thromb Haemost 2010; 8: 148–156.10.1111/j.1538-7836.2009.03584.xCrossRefGoogle ScholarPubMed
Kucuk, M, Ozdemir, R, Karadeniz, C, et al. Red blood cell distribution width: can it be a predictive marker for long-term valvular involvement in children with acute rheumatic carditis?. Int J Lab Hematol 2016; 38: 569–575.CrossRefGoogle ScholarPubMed
Mese, T, Guven, B, Yilmazer, MM, et al. Platelet activation markers in children with congenital heart disease associated with pulmonary arterial hypertension. Congenit Heart Dis 2018; 13: 506–511.10.1111/chd.12616CrossRefGoogle ScholarPubMed
Efe, S, Asker, İ, İnal, V. Prognostic Significance of Critical Patients’ Platelet Indexes in Mixed Type Critical Care Unit. Yoğun Bakım Derg 2019; 10: 13–17.Google Scholar