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Investigation of the MYH11 gene in sporadic patients with an isolated persistently patent arterial duct

Published online by Cambridge University Press:  24 October 2007

Limin Zhu ,
Damien Bonnet ,
Magali Boussion ,
Benoît Vedie ,
Daniel Sidi  and
Xavier Jeunemaitre
Limin Zhu
Affiliation:
AP-HP, Hôpital Européen Georges Pompidou, Département de Génétique, 75015, Paris, France INSERM, Unit 772; Collège de France, Paris, France Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
Damien Bonnet
Affiliation:
AP-HP, Hôpital Necker Enfant Malades, Département de Cardiologie Pédiatrique, Paris, France Université Paris-Descartes, Faculté de Médecine, Paris, France
Magali Boussion
Affiliation:
AP-HP, Hôpital Européen Georges Pompidou, Département de Génétique, 75015, Paris, France
Benoît Vedie
Affiliation:
AP-HP, Hôpital Européen Georges Pompidou, Département de Biochimie, Paris, France
Daniel Sidi
Affiliation:
AP-HP, Hôpital Necker Enfant Malades, Département de Cardiologie Pédiatrique, Paris, France Université Paris-Descartes, Faculté de Médecine, Paris, France
Xavier Jeunemaitre*
Affiliation:
AP-HP, Hôpital Européen Georges Pompidou, Département de Génétique, 75015, Paris, France INSERM, Unit 772; Collège de France, Paris, France Université Paris-Descartes, Faculté de Médecine, Paris, France
*
Correspondence to: Xavier Jeunemaitre MD, PhD, Département de Génétique, Hôpital Européen Georges Pompidou, 20-40 rue Leblanc 75015 Paris, France. Tel: +33 1 56 09 38 81; Fax: +33 1 56 09 38 84; E-mail: [email protected]
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Abstract

Persistent patency of the arterial duct is one of the most common congenital cardiac malformations. We recently showed that mutations in the MYH11 gene result in a disease combining familial thoracic aortic aneurysm and dissection, along with patency of the arterial duct. It is also known that the smooth muscle myosin heavy chain is involved in the physiological closure of the arterial duct. With this in mind, we investigated whether the MYH11 gene was a susceptibility gene for sporadic occurrence of isolated persistent patency of the arterial duct. We sequenced the entire coding sequence of the MYH11 gene in 60 Caucasian children with persistent patency born after 36 weeks of gestation. The frequencies of rare genetic variants, and single nucleotide polymorphisms, were compared with 192 normal controls. Two possible functional missense mutations were found in two affected individuals. Another rare variant, specifically p.Arg1535Gln, and two coding polymorphisms, namely p.Ala1234Thr and p.Val1289Ala, had allele frequencies similar to those in controls. Haplotype analysis after estimating linkage disequilibrium was carried out using six polymorphisms. Individual genotypes were distributed similarly among cases and controls. Only one of the seven major haplotypes was significantly less frequent among cases, at 0.07, than among controls, when the figure was 0.22 (OR 0.23 [0.08–0.27]). Our findings suggest that the MYH11 gene is involved in only rare instances when persistent patency of the arterial duct occurs in sporadic fashion.

Keywords

Congenital heart diseasepolymorphismgeneticsmyosin
Type
Original Article
Information
Cardiology in the Young , Volume 17 , Issue 6 , December 2007 , pp. 666 - 672
Copyright
Copyright © Cambridge University Press 2007

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