Florida is the fourth largest state in the United States of America. “Heart Week in Florida” is a joint collaborative project sponsored by The Children's Hospital of Philadelphia and The Congenital Heart Institute of Florida. The cardiac programme of Children's Hospital of Philadelphia is one of the largest and most prestigious comprehensive cardiac programmes in the world. The Congenital Heart Institute of Florida is the largest programme providing services for patients with congenital cardiac disease in Florida. Both institutions are very grateful to Bob Anderson, and the team at Cardiology in the Young, for their support of “Heart Week in Florida”, and for the opportunity to publish this Supplement. Bob Anderson was a valued faculty member, and tremendous supporter, of both the fourth annual International Symposium on Congenital Heart Disease held at All Children's Hospital and University of South Florida, and the seventh annual Update on Pediatric Cardiovascular Disease organized by Children's Hospital of Philadelphia.