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Early postoperative remodelling following repair of tetralogy of Fallot utilising unsedated cardiac magnetic resonance: a pilot study

Published online by Cambridge University Press:  15 February 2018

Michael P. DiLorenzo Open the ORCID record for Michael P. DiLorenzo [Opens in a new window] ,
Elizabeth Goldmuntz ,
Susan C. Nicolson ,
Mark A. Fogel  and
Laura Mercer-Rosa
Michael P. DiLorenzo*
Affiliation:
Department of Pediatrics, Division of Pediatric Cardiology, New York-Presbyterian/Morgan Stanley Children’s Hospital, Columbia University Medical Center, New York, NY, USA Department of Pediatrics, Division of Pediatric Cardiology, The Children’s Hospital of Philadelphia, Philadelphia, PA, USA
Elizabeth Goldmuntz
Affiliation:
Department of Pediatrics, Division of Pediatric Cardiology, The Children’s Hospital of Philadelphia, Philadelphia, PA, USA
Susan C. Nicolson
Affiliation:
Department of Anesthesia, The Children’s Hospital of Philadelphia, Philadelphia, PA, USA
Mark A. Fogel
Affiliation:
Department of Pediatrics, Division of Pediatric Cardiology, The Children’s Hospital of Philadelphia, Philadelphia, PA, USA
Laura Mercer-Rosa
Affiliation:
Department of Pediatrics, Division of Pediatric Cardiology, The Children’s Hospital of Philadelphia, Philadelphia, PA, USA
*
Author for correspondence: M. P. DiLorenzo, MD, MSCE, New York-Presbyterian/Morgan Stanley Children’s Hospital, 3959 Broadway, 2 North, New York, NY 10032, USA. Tel: 212 304 7492; Fax: 212 342 5704; E-mail: [email protected]
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Abstract

Introduction

The right ventricular adaptations early after surgery in infants with tetralogy of Fallot are important to understand the changes that occur later on in life; this physiology has not been fully delineated. We sought to assess early postoperative right ventricular remodelling in patients with tetralogy of Fallot by cardiac MRI.

Materials and method

Subjects with tetralogy of Fallot under 1 year of age were recruited following complete surgical repair for tetralogy of Fallot. Protocol-based cardiac MRI to assess anatomy, function, and flows was performed before hospital discharge using the feed and sleep technique, an unsedated imaging technique.

Results

MRI was completed in 16 subjects at a median age of 77 days (interquartile range 114). There was normal ventricular ejection fraction and indexed right ventricular end-diastolic volume (48±13 cc/m2), but elevated right ventricular mass (z score 6.2±2.4). Subjects requiring a transannular patch or right ventricle to pulmonary artery conduit had moderate pulmonary insufficiency (regurgitant fraction 27±16%).

Discussion

Early right ventricular remodelling after surgical repair for tetralogy of Fallot is characterised by significant pulmonary regurgitation, right ventricular hypertrophy, and lack of dilation. Performing cardiac MRI using the feed and sleep technique is feasible in infants younger than 5 months. These results might open new avenues to study longitudinal right ventricular changes in tetralogy of Fallot and to further explore the utility of unsedated MRI in patients with other types of CHDs.

Keywords

Tetralogy of FallotCHDcardiac MRIright ventricle
Type
Original Articles
Information
Cardiology in the Young , Volume 28 , Issue 5 , May 2018 , pp. 697 - 701
Copyright
© Cambridge University Press 2018 

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