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Do toxic metals and trace elements have a role in the pathogenesis of conotruncal heart malformations?

Published online by Cambridge University Press:  18 October 2016

Afsin A. Kundak ,
Ayhan Pektas ,
Aysegul Zenciroglu ,
Semra Ozdemir ,
Umit B. Barutcu ,
Utku A. Orun  and
Nurullah Okumus
Afsin A. Kundak
Affiliation:
Department of NeonatologyAfyon Kocatepe University Medical Faculty Hospital, Afyonkarahisar, Turkey
Ayhan Pektas*
Affiliation:
Department of Pediatric Cardiology, Afyon Kocatepe University Medical Faculty Hospital, AfyonkarahisarTurkey
Aysegul Zenciroglu
Affiliation:
Department of Neonatology, Dr. Sami Ulus Obstetrics, Gynecology and Pediatrics Research and Education Hospital, AnkaraTurkey
Semra Ozdemir
Affiliation:
Department of Biochemistry, Cerrahpasa University Medical Faculty Hospital, IstanbulTurkey
Umit B. Barutcu
Affiliation:
Department of Biochemistry, Cerrahpasa University Medical Faculty Hospital, IstanbulTurkey
Utku A. Orun
Affiliation:
Department of Pediatric Cardiology, Dr. Sami Ulus Obstetrics, Gynecology and Pediatrics Research and Education Hospital, Ankara, Turkey
Nurullah Okumus
Affiliation:
Department of Neonatology, Dr. Sami Ulus Obstetrics, Gynecology and Pediatrics Research and Education Hospital, AnkaraTurkey
*
Correspondence to: A. Pektas, MD, Selcuklu Mah. Adnan Kahveci Cad. No: 16/2 03128, Afyonkarahisar, Turkey. Tel: +90 272 246 3333, +90 532 545 1428; Fax: +90 272 246 3322; E-mail: [email protected]
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Abstract

Objective

The aim of the present study was to determine the role of toxic elements and trace elements in the pathogenesis of conotruncal heart defects by measuring their concentrations in the first meconium specimens of the affected newborns.

Methods

Concentrations of lead, cadmium, iron, zinc, and copper were measured in 1st-day meconium specimens that were collected from 60 newborns with conotruncal heart defects (Group I) and 72 healthy newborns (Group II).

Results

The newborns with conotruncal defects and the healthy newborns had statistically similar demographic and clinical characteristics. When compared with healthy newborns, mean concentrations of lead, cadmium, iron, zinc, and copper were significantly higher in newborns with conotruncal heart defects (p=0.001 for each). In total, 51 newborns with conotruncal heart defects had normal karyotype. These newborns had significantly higher concentrations of lead, cadmium, iron, zinc, and copper when compared with healthy newborns. There were significant and positive correlations between the concentrations of lead and cadmium (r=0.618, p=0.001), lead and iron (r=0.368, p=0.001), lead and zinc (r=0.245, p=0.005), lead and copper (r=0.291, p=0.001), cadmium and iron (r=0.485, p=0.001), cadmium and zinc (r=0.386, p=0.001), and cadmium and copper (r=0.329, p=0.001).

Conclusion

Toxic metals and trace elements may disturb DNA repair mechanisms by impairing DNA methylation profiles, and thus have a role in the pathogenesis of conotruncal heart defects.

Keywords

CHDtoxic metaltrace element
Type
Original Articles
Information
Cardiology in the Young , Volume 27 , Issue 2 , March 2017 , pp. 312 - 317
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Copyright
© Cambridge University Press 2016 

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