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Continuous inhaled iloprost in a neonate with d-transposition of the great arteries and severe pulmonary arterial hypertension

Published online by Cambridge University Press:  29 July 2015

John C. Dykes*
Affiliation:
Nicklaus Children’s Hospital, Department of Cardiology, Miami, Florida, United States of America
Marilyn Torres
Affiliation:
Nicklaus Children’s Hospital, Department of Cardiology, Miami, Florida, United States of America
Plato J. Alexander
Affiliation:
Nicklaus Children’s Hospital, Department of Cardiology, Miami, Florida, United States of America
*
Correspondence to: J. C. Dykes, MD, Nicklaus Children’s Hospital, Department of Cardiology, 3100 SW 62nd Avenue, Miami, FL 33155, United States of America. Tel: 305 666 6511; Fax: 305 662 8304; E-mail: [email protected]

Abstract

This report describes the case of a neonate with d-transposition of the great arteries and severe pulmonary arterial hypertension stabilised in the post-operative period with continuous iloprost nebulisation. To our knowledge, this is the first documented method of treating post-operative severe pulmonary arterial hypertension with continuous inhaled iloprost in a patient with complex CHD. We found this method of delivering the drug very effective in stabilising haemodynamic swings in the setting of severe pulmonary arterial hypertension.

Type
Brief Reports
Copyright
© Cambridge University Press 2015 

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References

1. Roofthooft, MT, Bergman, KA, Waterbolk, TW, Ebels, T, Bartelds, B, Berger, RM. Persistent pulmonary hypertension of the newborn with transposition of the great arteries. Ann Thorac Surg 2007; 83: 14461450.Google Scholar
2. Ivy, D. Advances in pediatric pulmonary arterial hypertension. Curr Opin Cardiol 2012; 27: 7081.Google Scholar
3. Tissot, C, Beghetti, M. Review of inhaled iloprost for the control of pulmonary artery hypertension in children. Vasc Health Risk Manag 2009; 5: 325331.Google Scholar
4. Ivy, DD, Doran, AK, Smith, KJ, et al. Short- and long-term effects of inhaled iloprost therapy in children with pulmonary arterial hypertension. J Am Coll Cardiol 2008; 51: 161169.Google Scholar
5. Mulligan, C, Beghetti, M. Inhaled iloprost for the control of acute pulmonary hypertension in children: a systematic review. Pediatr Crit Care Med 2012; 13: 472480.Google Scholar
6. Opitz, CF, Wensel, R, Bettmann, M, et al. Assessment of the vasodilator response in primary pulmonary hypertension. comparing prostacyclin and iloprost administered by either infusion or inhalation. Eur Heart J 2003; 24: 356365.Google Scholar
7. Max, M, Rossaint, R. Inhaled prostacyclin in the treatment of pulmonary hypertension. Eur J Pediatr 1999; 158 (Suppl 1): S23S26.Google Scholar