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Anakinra as rescue therapy for steroid-dependent idiopathic recurrent pericarditis in children: case report and literature review

Published online by Cambridge University Press:  04 December 2018

Moises Rodriguez-Gonzalez Open the ORCID record for Moises Rodriguez-Gonzalez [Opens in a new window] ,
Estefania Ruiz-Gonzalez  and
Ana Castellano-Martinez
Moises Rodriguez-Gonzalez*
Affiliation:
Pediatric Cardiology Department, Hospital Universitario Puerta del Mar, Cadiz, Spain
Estefania Ruiz-Gonzalez
Affiliation:
Pediatrics Department, Hospital Universitario Puerta del Mar, Cadiz, Spain
Ana Castellano-Martinez
Affiliation:
Pediatric Nephrology Department, Puerta del Mar University Hospital, Cadiz, Spain
*
Author for correspondence: M. Rodriguez-Gonzalez, Department of Pediatric Cardiology, Puerta del Mar University Hospital, Ana de Viya Avenue 34, 11009 Cadiz, Spain. Tel: 34 956002700; Fax: 34 956002085; E-mail: [email protected]
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Abstract

In approximately 5% of patients with idiopathic recurrent pericarditis, the disease usually follows a chronic relapsing course, and children can develop dependence and side effects of prolonged high-dose corticosteroid regimens. In this setting anakinra, a recombinant human interleukin-1 competitive receptor antagonist that blocks the biologic effects of interleukin-1, thereby reducing systemic inflammatory responses, appears to be one of the most promising strategies. We report an adolescent with steroid-dependent idiopathic recurrent pericarditis that was successfully treated with anakinra, highlighting that this therapeutic option seems to be an effective, rapidly acting, steroid-sparing, and relatively safe agent for the treatment of this entity in children.

Keywords

Recurrent pericarditisanakinrainterleukin-1 receptor antagonistchildrenauto-inflammatory disease
Type
Brief Report
Information
Cardiology in the Young , Volume 29 , Issue 2 , February 2019 , pp. 241 - 243
Copyright
© Cambridge University Press 2018 

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Footnotes

Cite this article: Rodriguez-Gonzalez M, Ruiz-Gonzalez E, Castellano-Martinez A. (2018) Anakinra as rescue therapy for steroid-dependent idiopathic recurrent pericarditis in children: case report and literature review. Cardiology in the Young page 241 of 243. doi: 10.1017/S1047951118002020

References

1. Imazio, M, Brucato, A, Pluymaekers, N, et al. Recurrent pericarditis in children and adolescents. J Cardiovasc Med 2016; 17: 707–712.Google Scholar
2. Lazaros, G, Antonatou, K, Vassilopoulos, D. The therapeutic role of interleukin-1 inhibition in idiopathic recurrent pericarditis: current evidence and future challenges. Front Med 2017; 4: 99–106.Google Scholar
3. Cantarini, L, Lopalco, G, Selmi, C, et al. Autoimmunity and autoinflammation as the yin and yang of idiopathic recurrent acute pericarditis. Autoimmun Rev 2015; 14: 90–97.Google Scholar
4. Scott, IC, Hajela, V, Hawkins, PN, Lachmann, HJ. A case series and systematic literature review of anakinra and immunosuppression in idiopathic recurrent pericarditis. J Cardiol Cases 2011; 4: e93–e97.Google Scholar
5. Picco, P, Brisca, G, Traverso, F, Loy, A, Gattorno, M, Martini, A. Successful treatment of idiopathic recurrent pericarditis in children with interleukin-1beta receptor antagonist (anakinra): an unrecognized autoinflammatory disease? Arthritis Rheum 2009; 60: 264–268.Google Scholar
6. Scardapane, A, Brucato, A, Chiarelli, F, Breda, L. Efficacy of an interleukin-1β receptor antagonist (anakinra) in idiopathic recurrent pericarditis. Pediatr Cardiol 2012; 34: 1989–1991.Google Scholar
7. Murias Loza, S, García-Guereta Silva, L, Alcobendas Rueda, RM, Remesal Camba, A. Eficacia de anakinra como tratamiento de la pericarditis recurrente. Anales de Pediatría 2018; 88: 223–224.Google Scholar
8. Finetti, M, Insalaco, A, Cantarini, L, et al. Long-term efficacy of interleukin-1 receptor antagonist (anakinra) in corticosteroid-dependent and colchicine-resistant recurrent pericarditis. J Pediatr 2014; 164: 1425–31.e1.Google Scholar
9. Brucato, A, Imazio, M, Gattorno, M, et al. Effect of anakinra on recurrent pericarditis among patients with colchicine resistance and corticosteroid dependence. J Am Med Assoc 2016; 316: 1906–1907.Google Scholar
10. Alraies, MC, AlJaroudi, W, Yarmohammadi, H, et al. Usefulness of cardiac magnetic resonance-guided management in patients with recurrent pericarditis. Am J Cardiol 2015; 115: 542–547.Google Scholar