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An unusual case of concurrent Kounis syndrome and prolonged QT in a young patient

Published online by Cambridge University Press:  17 September 2021

Emrah Erdogan
Affiliation:
Department of Cardiology, Barts Heart Centre, Barts Health NHS Trust, London, UK
Murat Cap
Affiliation:
Van Yuzuncu yil Hospital, Department of Cardiology, Van, Turkey
Gorkem Kus
Affiliation:
Agri State Hospital, Agri, Turkey
Cem Gokhan
Affiliation:
Agri State Hospital, Agri, Turkey
Yakup Kilic*
Affiliation:
Hammersmith Hospital, Imperial College Trust, London, UK
*
Address for correspondence: Dr Yakup Kilic, MD, Hammersmith Hospital, Imperial College Trust, Du Cane Road, London W12 0HS, UK. Tel: +44 7913965676. E-mail: [email protected]

Abstract

Allergic reactions related to drug use is a common entity presenting often from minor urticaria to life-threatening anaphylactoid reactions. A common but easily overlooked diagnosis, Kounis syndrome, is an established hypersensitivity coronary disorder induced by drugs, foods, environmental factors, and coronary stents that can present in the same way as non-allergy-induced acute coronary syndrome. Here within, we present a unique case of dual presentation of Kounis syndrome and prolonged QTc in a young patient after a single dose of Domperidone and Lansoprazole.

Type
Brief Report
Copyright
© The Author(s), 2021. Published by Cambridge University Press

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References

Kounis, NG, Zavras, GM. Histamine-induced coronary artery spasm: the concept of allergic angina. Brit J Clin Pract 1991; 45: 121− 128.Google ScholarPubMed
Abdelghany, M, Subedi, R, Shah, S, Kozman, H. Kounis syndrome: a review article on epidemiology, diagnostic findings, management and complications of allergic acute coronary syndrome. Int J Cardiol 2017; 232: 1− 4. DOI 10.1016/j.ijcard.2017.01.124.CrossRefGoogle ScholarPubMed
Fassio, F, Losappio, L, Antolin-Amerigo, D, et al. Kounis syndrome: a concise review with focus on management. Eur J Intern Med 2016; 30: 7− 10.CrossRefGoogle ScholarPubMed
Chen, JP, Hou, D, Pendyala, L, Goudevenos, JA, Kounis, NG. Drug-eluting stent thrombosis: the Kounis hypersensitivity-associated acute coronary syndrome revisited. JACC Cardiovasc Interv 2009; 2: 583− 593.CrossRefGoogle ScholarPubMed
Kounis, NG, Kourelis, T, Hahalis, G, Manola, A, Kourelis, T, Theoharides, T. Kounis syndrome (allergic angina and allergic myocardial infarction). In: Gallo, AP, Jones, ML (eds). Angina Pectoris Etiology, Pathogenesis and Treatment. Nova Biomedical Books, New York, 2008.Google Scholar
Rossi, M, Giorgi, G. Domperidone and long QT syndrome. Curr Drug Saf 2010; 5: 257− 262.CrossRefGoogle ScholarPubMed
Vlahos, NP, Vavilis, GK, Giannelou, AG, et al. Hypersensitivity to proton pump inhibitors: lansoprazole-induced Kounis syndrome. Int J Cardiol 2009; 134: e94− e96.CrossRefGoogle ScholarPubMed
Renda, F, Marotta, E, Landoni, G, Belletti, A, Cuconato, V, Pani, L. Kounis syndrome due to antibiotics: a global overview from pharmacovigilance databases. Int J Cardiol 2016; 224: 406− 411.CrossRefGoogle ScholarPubMed
Celiker, M, Tuncer, M, Sekeralmaz, A. A case with repeated recurrent acute coronary syndrome due to pseudoephedrine use: Kounis syndrome. Case Rep Med 2014; 2014: 742905.CrossRefGoogle ScholarPubMed
Leibee, C, Getachew, B, Ehmann, MR. Vancomycin-induced Kounis syndrome. Am J Emerg Med 2019; 37: 1806.e3− 1806.e5.CrossRefGoogle ScholarPubMed
Kounis, NG, Kouni, SN, Koutsojannis, CM. Myocardial infarction after aspirin, and Kounis syndrome. J R Soc Med 2005; 98: 296.CrossRefGoogle ScholarPubMed
Maragkoudakis, S, Hamilos, M, Kallergis, E, Vardas, P. Type 2 Kounis syndrome in an allergic woman: an uncommon presentation of acute coronary syndrome. J Cardiol Cases 2013; 8: 176− 178. DOI 10.1016/j.jccase.2013.08.003.CrossRefGoogle Scholar