Hostname: page-component-78c5997874-m6dg7 Total loading time: 0 Render date: 2024-11-19T10:08:42.791Z Has data issue: false hasContentIssue false
  • English
  • Français

Amiodarone-induced 2 to 1 atrioventricular block in association with prolongation of the QT interval

Published online by Cambridge University Press:  24 May 2005

Colin J. McMahon ,
William P. Laird  and
Arnold L. Fenrich
Colin J. McMahon
Affiliation:
Lillie Frank Abercrombie Division of Pediatric Cardiology, Texas Children's Hospital and Baylor College of Medicine, Houston, TX, USA
William P. Laird
Affiliation:
Lillie Frank Abercrombie Division of Pediatric Cardiology, Texas Children's Hospital and Baylor College of Medicine, Houston, TX, USA
Arnold L. Fenrich
Affiliation:
Lillie Frank Abercrombie Division of Pediatric Cardiology, Texas Children's Hospital and Baylor College of Medicine, Houston, TX, USA
Get access Rights & Permissions [Opens in a new window]

Abstract

The potential for development of 2 to 1 atrioventricular conduction in children with prolongation of the QT interval has been previously reported secondary to electrolytic disturbances. We report here a child who developed 2 to 1 atrioventricular conduction with prolongation of the QT interval following treatment with amiodarone for refractory supraventricular tachycardia. We highlight the importance of electrocardiographic monitoring to assess for those at risk of amiodarone toxicity, which may be manifested by prolongation of the QT interval and the simultaneous loss of atrioventricular conduction, and of equal importance the need for prompt conversion to an alternative anti-arrhythmic agent.

Keywords

Electrocardiographyatrioventricular conductiondrug treatment
Type
Brief Report
Information
Cardiology in the Young , Volume 13 , Issue 3 , June 2003 , pp. 305 - 307
Copyright
© 2003 Cambridge University Press

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Garson A, Dick M, Fournier A, et al. The long QT syndrome in children: an international study of 287 patients. Circulation 1993; 87: 1866–1872.Google Scholar
Trippel DL, Parsons MK, Gillette PC. Infants with long-QT syndrome and 2:1 atrioventricular block. Am Heart J 1995; 130: 1130–1134.Google Scholar
Li H, Fuentes-Garcia J, Towbin JA. Current concepts in long QT syndrome. Pediatr Cardiol 2000; 21: 542–550.Google Scholar
Splawski I, Shen J, Timothy KW, et al. Spectrum of mutations in long-QT syndrome genes. KVLQT1, HERG, SCN5A, KCNE 1 and KCNE 2. Circulation 2000; 102: 1178–1185.Google Scholar
Towbin JA, Vatta M, Li H. Genetics of Brugada, long QT, and arrhythmogenic right ventricular dysplasia syndromes. J Electrocardiol 2000; 33: 11–22.Google Scholar
Towbin JA, Vatta M. Molecular biology and the prolonged QT syndromes. Am J Med 2001; 110: 385–398.Google Scholar
Huang TC, Cecchin FC, Mahoney P, Portman MA. Corrected QT interval (QTc) prolongation and syncope associated with pseudohypoparathyroidism and hypocalcemia. J Pediatr 2000; 136: 404–407.Google Scholar
Akiyama T, Batchelder J, Worsman J, Moses HW, Jedlinski M. Hypocalcemic torsades de pointes. J Electrocardiol 1989; 22: 89–92.Google Scholar
Kubota T, Shimizu W, Kamakur S, Horie M. Hypokalemia-induced long QT syndrome with an underlying novel missense mutation in S4-S5 linker of KCNQ1. J Cardiovasc Electrophysiol 2000; 11: 1048–1054.Google Scholar
Drago F, Mazza A, Guccione P, Mafrici A, Di Liso G, Ragonese P. Amiodarone used alone or in combination with propranolol: a very effective therapy for tachyarrhythmias in infants and children. Pediatr Cardiol 1998; 19: 445–449.Google Scholar