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Abnormal histology of the aortic arch in coarctation of the aorta

Published online by Cambridge University Press:  19 August 2008

Derk W. Wolterbeek ,
Arie P. Kappetein  and
Adriana C. Gittenberger–de Groot
Derk W. Wolterbeek
Affiliation:
From the Department of Thoracic Surgery, University Hospital, Rijksuniversiteit, Leiden
Arie P. Kappetein
Affiliation:
From the Department of Thoracic Surgery, University Hospital, Rijksuniversiteit, Leiden
Adriana C. Gittenberger–de Groot*
Affiliation:
Department of Anatomy and Embryology, Rijksuniversiteit, Leiden
*
Dr. Adriana C. Gittenberger Groot, Department of Anatomy and Embryology, Postbus 9602, 2300 RC Leiden, The Netherlands, Tel. (31) 71-276684.
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Summary

We examined the number of elastic lamellae in the wall of the proximal aortic arch, aortic isthmus and descending aorta in patients with coarctation of the aorta. In the proximal aortic arch, the number of elastic lamellae was significantly lower in patients with coarctation compared to those with normal hearts without aortic anomalies and those with intracardiac defects but without aortic anomalies. The isthmus also showed a significantly lower number of elastic lamellae in the presence of preductal coarctation. In the descending aorta, the number of elastic lamellae was not significantly different between the different groups. There is doubt about the etiology of coarctation. Recent investigations showed that cells from the cardiac neural crest contribute to the formation of the arch arteries and the media of the arch. A developmental error of the neural crest might be responsible for the abnormal mural structures found in patients with aortic coarctation.

Keywords

Isthmus hypoplasiaetiologyneural crestelastic lamellae
Type
Original Articles
Information
Cardiology in the Young , Volume 3 , Issue 4 , October 1993 , pp. 412 - 416
Copyright
Copyright © Cambridge University Press 1993

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