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Virology and Histopathology of the Trigeminal Ganglia of Americans and Japanese

Published online by Cambridge University Press:  18 September 2015

K.G. Warren ,
Z. Wroblewska ,
H. Okabe ,
S.M. Brown ,
D.H. Gilden ,
H. Koprowski ,
L.B. Rorke ,
J. Subak-Sharpe  and
T. Yonezawa
K.G. Warren
Affiliation:
Multiple Sclerosis Research Centre of the Wistar Institute of Anatomy and Biology, and the Department of Neurology, Hospital of the University of Pennsylvania and the First Department of Pathology, Kyoto Prefectural University School of Medicine, Kyoto Japan and the Institute of Virology, University of Glasgow, Glasgow, Scotland
Z. Wroblewska
Affiliation:
Multiple Sclerosis Research Centre of the Wistar Institute of Anatomy and Biology, and the Department of Neurology, Hospital of the University of Pennsylvania and the First Department of Pathology, Kyoto Prefectural University School of Medicine, Kyoto Japan and the Institute of Virology, University of Glasgow, Glasgow, Scotland
H. Okabe
Affiliation:
Multiple Sclerosis Research Centre of the Wistar Institute of Anatomy and Biology, and the Department of Neurology, Hospital of the University of Pennsylvania and the First Department of Pathology, Kyoto Prefectural University School of Medicine, Kyoto Japan and the Institute of Virology, University of Glasgow, Glasgow, Scotland
S.M. Brown
Affiliation:
Multiple Sclerosis Research Centre of the Wistar Institute of Anatomy and Biology, and the Department of Neurology, Hospital of the University of Pennsylvania and the First Department of Pathology, Kyoto Prefectural University School of Medicine, Kyoto Japan and the Institute of Virology, University of Glasgow, Glasgow, Scotland
D.H. Gilden
Affiliation:
Multiple Sclerosis Research Centre of the Wistar Institute of Anatomy and Biology, and the Department of Neurology, Hospital of the University of Pennsylvania and the First Department of Pathology, Kyoto Prefectural University School of Medicine, Kyoto Japan and the Institute of Virology, University of Glasgow, Glasgow, Scotland
H. Koprowski*
Affiliation:
Multiple Sclerosis Research Centre of the Wistar Institute of Anatomy and Biology, and the Department of Neurology, Hospital of the University of Pennsylvania and the First Department of Pathology, Kyoto Prefectural University School of Medicine, Kyoto Japan and the Institute of Virology, University of Glasgow, Glasgow, Scotland
L.B. Rorke
Affiliation:
Multiple Sclerosis Research Centre of the Wistar Institute of Anatomy and Biology, and the Department of Neurology, Hospital of the University of Pennsylvania and the First Department of Pathology, Kyoto Prefectural University School of Medicine, Kyoto Japan and the Institute of Virology, University of Glasgow, Glasgow, Scotland
J. Subak-Sharpe
Affiliation:
Multiple Sclerosis Research Centre of the Wistar Institute of Anatomy and Biology, and the Department of Neurology, Hospital of the University of Pennsylvania and the First Department of Pathology, Kyoto Prefectural University School of Medicine, Kyoto Japan and the Institute of Virology, University of Glasgow, Glasgow, Scotland
T. Yonezawa
Affiliation:
Multiple Sclerosis Research Centre of the Wistar Institute of Anatomy and Biology, and the Department of Neurology, Hospital of the University of Pennsylvania and the First Department of Pathology, Kyoto Prefectural University School of Medicine, Kyoto Japan and the Institute of Virology, University of Glasgow, Glasgow, Scotland
*
Wistar Institute of Anatomy and Biology, 36th Street at Spruce, Philidelphia, PA 19104, USA.
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Herpes simplex virus in the trigeminal ganglia of humans was studied in Philadelphia, Pennsylvania, United States of A merica, and in Kyoto, Japan. The prevalence of recurrent herpes labialis and of clinically latent herpes simplex virus within trigeminal ganglia was determined in inhabitants of the two cities. In addition, a comparison was made of the prevalence of mononuclear cell infiltration in the trigeminal ganglia of Americans and Japanese. Recurrent herpes labialis was found to be significantly less common in the Japanese city than in the American city. Herpes simplex virus was rescued less commonly from the trigeminal ganglia of cadavers in Japan than in America. The difference was significant. The frequency of mononuclear cell infiltration in the trigeminal ganglia of Americans and Japanese is not significantly different. These observations, as well as previously reported serological studies, suggest that despite the ubiquitous nature of herpes simplex virus in A merica and Japan, the Japanese have less clinically overt desease caused by this virus.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 5 , Issue 4 , November 1978 , pp. 425 - 430
Copyright
Copyright © Canadian Neurological Sciences Federation 1978

References

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