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Valvular Heart Disease in Pergolide-Treated Parkinson's Disease

Published online by Cambridge University Press:  02 December 2014

James Scozzafava ,
Jennifer Takahashi ,
Wendy Johnston ,
Lakshmi Puttagunta  and
W.R. Wayne Martin
James Scozzafava
Affiliation:
Division of Neurology, University of Alberta, Edmonton, Alberta, Canada
Jennifer Takahashi
Affiliation:
Division of Neurology, University of Alberta, Edmonton, Alberta, Canada
Wendy Johnston
Affiliation:
Division of Neurology, University of Alberta, Edmonton, Alberta, Canada
Lakshmi Puttagunta
Affiliation:
Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada
W.R. Wayne Martin*
Affiliation:
Division of Neurology, University of Alberta, Edmonton, Alberta, Canada
*
Movement Disorders Clinic, Glenrose Rehabilitation Hospital, 10230-111 Avenue, Edmonton, Alberta, T5G 0B7, Canada
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Abstract:

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Background:

A 61-year-old woman with Parkinson's disease, receiving pergolide 1.75 mg four times daily, was admitted with progressive dyspnea.

Methods:

Investigations revealed mitral and aortic regurgitation. She underwent surgical mitral replacement and aortic repair, but had a postoperative course characterized by repeated bouts of congestive heart failure.

Results:

Severe tricuspid valve (TV) regurgitation developed within one month after the TV was reported on echocardiography to be relatively normal. Subsequent discontinuation of pergolide was associated with symptomatic improvement.

Conclusions:

This case illustrates the severity and rapidity with which cardiac valvular abnormalities can develop in patients receiving pergolide.

Résumé

RÉSUMÉ Contexte:

Une femme âgée de 61 ans, traitée avec du pergolide 1,75 mg quatre fois par jour pour une maladie de Parkinson, a été hospitalisée pour dyspnée progressive.

Méthodes:

L'évaluation de la patiente a mis en évidence une régurgitation mitrale et aortique. Elle a subi un remplacement mitral et une réfection aortique. Au cours des suites opératoires, elle a présenté des épisodes d'insuffisance cardiaque à répétition.

Résultats:

Bien que le rapport d'échographie ait fait état d'une tricuspide relativement normale un mois auparavant, on a constaté subséquemment une régurgitation tricuspidienne sévère. Les symptômes ont régressé à l'arrêt du pergolide.

Conclusions:

Cette observation illustre la sévérité et la rapidité d'installation de la valvulopathie cardiaque chez les patients sous pergolide.

Type
Case Report
Information
Canadian Journal of Neurological Sciences , Volume 33 , Issue 1 , February 2006 , pp. 111 - 113
Copyright
Copyright © The Canadian Journal of Neurological 2006

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