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Valproic Acid and Plasma Levels of Primidone and Derived Phenobarbital

Published online by Cambridge University Press:  18 September 2015

J Bruni
J Bruni*
Affiliation:
the Department of Medicine (Neurology), Wellesley Hospital and University of Toronto
*
Room 318, E.K. Jones Building, Wellesley Hospital, 160 Wellesley St. East, Toronto, Ontario, M4Y 1J3, Canada
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Summary

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Five patients were studied to determine whether kinetic interaction occurs between valproic acid and primidone. During concurrent administration of primidone and valproic acid no significant interaction was observed. Primidone and derived phenobarbital levels did not change significantly. No adjustment of primidone dose was required when valproic acid was used as adjunctive therapy.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 8 , Issue 1 , February 1981 , pp. 91 - 92
Copyright
Copyright © Canadian Neurological Sciences Federation 1981

References

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