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Ultrastructural Observations on Spinal Ganglion Biopsy in Friedreich’s Ataxia: A Preliminary Report

Published online by Cambridge University Press:  18 September 2015

J. Lamarche ,
C. Luneau  and
B. Lemieux
J. Lamarche
Affiliation:
Departments of Pathology, Neurosurgery and Pediatrics, Centre Hospitalier Universitaire, Sherbrooke, Quebec
C. Luneau
Affiliation:
Departments of Pathology, Neurosurgery and Pediatrics, Centre Hospitalier Universitaire, Sherbrooke, Quebec
B. Lemieux
Affiliation:
Departments of Pathology, Neurosurgery and Pediatrics, Centre Hospitalier Universitaire, Sherbrooke, Quebec
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Abstract:

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We report the preliminary study of a dorsal root ganglion obtained at biopsy during a surgical intervention in a patient with Friedreich’s ataxia. There was an apparent decrease in the number of large myelinated fibers without necrosis, but with numerous axonal swellings consisting mainly of dense accumulated neurofilaments. Large amounts of lipofuscin were also found as well as some onion bulb formations suggesting a process of axonal atrophy.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 9 , Issue 2 , May 1982 , pp. 137 - 139
Copyright
Copyright © Canadian Neurological Sciences Federation 1982

References

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