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The Treatment of the Restless Legs Syndrome with Clonazepam: A Prospective Controlled Study

Published online by Cambridge University Press:  18 September 2015

Dan Boghen ,
Lise Lamothe ,
Robert Elie ,
Roger Godbout  and
Jacques Montplaisir
Dan Boghen*
Affiliation:
The Neurology Service, Montréal, and the Faculty of Medicine, Université de Montréal, Montréal, Québec
Lise Lamothe
Affiliation:
Department of Pharmacy, Montréal, and the Faculty of Medicine, Université de Montréal, Montréal, Québec
Robert Elie
Affiliation:
Hôtel-Dieu de Montréal, The Louis-H. Lafontaine Hospital, Montréal, and the Faculty of Medicine, Université de Montréal, Montréal, Québec
Roger Godbout
Affiliation:
The Sleep Disorders Center, Sacré-Coeur Hospital, Montréal, and the Faculty of Medicine, Université de, Montréal, Québec
Jacques Montplaisir
Affiliation:
The Sleep Disorders Center, Sacré-Coeur Hospital, Montréal, and the Faculty of Medicine, Université de, Montréal, Québec
*
Neurology Service, Hôtel-Dieu de Montréal, 3840 St Urbain, Montréal, Québec H2W 1T8
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Abstract:

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The effect of clonazepam on the restless legs syndrome was studied in a group of 6 patients. Following a drug-free period, 3 patients received clonazepam for 4 weeks followed by placebo for 4 weeks thereafter and 3 patients received the same medication and for the same length of time but in reverse order. The effectiveness of the medication was evaluated by means of a self-rating system in which patients assigned a score daily to the degree of discomfort experienced in the previous 24 hours. Three patients improved on clonazepam but 2 of these also improved on placebo. Clonazepam was not shown to be significantly more effective than placebo in the treatment of RLS.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 13 , Issue 3 , August 1986 , pp. 245 - 247
Copyright
Copyright © Canadian Neurological Sciences Federation 1986

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