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Treadmill Training Effects on Neurological Outcome After Middle Cerebral Artery Occlusion in Rats

Published online by Cambridge University Press:  02 December 2014

Yea-Ru Yang ,
Ray-Yau Wang ,
Paulus Shyi-Gang Wang  and
Shang-Ming Yu
Yea-Ru Yang
Affiliation:
Faculty and Institute of Physical Therapy, National Yang-Ming University, Shih-Pai, Taipei, Taiwan
Ray-Yau Wang
Affiliation:
Faculty and Institute of Physical Therapy, National Yang-Ming University, Shih-Pai, Taipei, Taiwan
Paulus Shyi-Gang Wang
Affiliation:
Department and Institute of Physiology, National Yang-Ming University, Shih-Pai, Taipei, Taiwan
Shang-Ming Yu
Affiliation:
Institute of Anatomy and Cell Biology, National Yang-Ming University, Shih-Pai, Taipei, Taiwan
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Abstract

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Background:

Treadmill training is used for promoting rhythmical vigorous walking and for task-related training in patients with stroke. The neurological impact of treadmill training has not been established. The present investigation is aimed at (1) examining neurological changes over a four-week period after middle cerebral artery occlusion (MCAO) in rats and (2) assessing the impact of one-week, two-week and four-week treadmill training in MCAO rats.

Methods:

Male Sprague-Dawley rats were subjected to 60-minute right MCAO. All rats were randomly assigned to one of seven groups. Infarct volume and neurological score were measured.

Results:

Rats sacrificed 24 hours post MCAO had the largest infarct volumes (171.4 ± 14.4 mm3) and the highest neurological score (median: 2, range: 1-3). We noted that without treadmill training, infarct sizes and neurological score diminished with time. Treadmill training for at least one week further reduced infarct volume and significantly improved neurologic function in MCAO rats.

Conclusion:

Treadmill training after focal cerebral ischemia significantly improves neurological outcome in MCAO rats. Treadmill training may be beneficial for ischemic brain recovery.

Résumé:

RÉSUMÉ: Introduction:

L’entraînement sur tapis roulant est utilisé pour promouvoir la marche rythmique rapide et l’entraînement à la tâche chez les patients ayant subi un accident vasculaire cérébral. L’impact neurologique de l’entraînement sur tapis roulant n’a jamais été étudié. Cette étude vise à: 1) examiner les changements neurologiques qui surviennent dans les quatre premières semaines après l’occlusion de l’artère cérébrale moyenne (OACM) chez des rats et d’évaluer l’impact d’un entraînement sur tapis roulant de une, deux et quatre semaines chez des rats ayant subi une OACM.

Méthodes:

Des rats mâles Sprague-Dawley ont subi une OACM d’une durée de 60 minutes. Ils ont été divisés en sept groupes. Le volume de l’infarctus et le score neurologique ont été mesurés.

Résultats:

Les rats sacrifiés 24 heures après l’OACM avaient les plus gros infarctus (171,4 ± 14,4 mm3) et le score neurologique le plus élevé (médiane: 2; écart: 1 à 3). Sans entraînement sur tapis roulant, la taille de l’infarctus et le score neurologique diminuaient avec le temps. L’entraînement sur tapis roulant pendant au moins une semaine diminuait davantage le volume de l’infarctus et améliorait significativement la fonction neurologique des rats ayant subi une OACM.

Conclusions:

L’entraînement sur tapis roulant après une ischémie cérébrale focale améliore significativement l’issue neurologique chez les rats ayant subi une OACM. L’entraînement sur tapis roulant peut avoir un effet bénéfique sur la récupération après une ischémie cérébrale.

Type
Experimental Neurosciences
Information
Canadian Journal of Neurological Sciences , Volume 30 , Issue 3 , August 2003 , pp. 252 - 258
Copyright
Copyright © The Canadian Journal of Neurological 2003

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