Hostname: page-component-cd9895bd7-dk4vv Total loading time: 0 Render date: 2024-12-29T05:31:18.646Z Has data issue: false hasContentIssue false

Trace Amines and Mental Disorders

Published online by Cambridge University Press:  18 September 2015

Alan A. Boulton*
Affiliation:
The Psychiatric Research Division, University Hospital, Saskatoon, Saskatchewan S7N 0X0, Canada
*
Psychiatric Research Division, University Hospital, Saskatoon, Saskatchewan S7N 0X0, Canada
Rights & Permissions [Opens in a new window]

Summary:

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

In this brief review it will be possible to mention only superficially the bioclinical, behavioral, neurochemical, neuropharmacological and neurophysiological evidence to support the view that some of the trace amines [meta- and paratyramine (m-TA, p-TA), β-phenylethylamine (PE) and tryptamine (T)] may play a significant role in the propagation of nervous impulses and perhaps be involved in the etiology of certain mental disorders. More detailed comments will be found in some recent papers and reviews (Axelrodet al, 1976; Boulton, 1974, 1976, 1978, 1979; Boulton and Baker, 1975; Boulton and Juorio, 1979; Faurbye, 1968; Mosnaim and Wolfe, 1978; Sandler and Reynolds, 1976; Wyatl et al, 1977).

Type
Research Article
Copyright
Copyright © Canadian Neurological Sciences Federation 1980

References

REFERENCES

Axelrod, J., Saavedra, J. and Usdin, E. (1978). In, Trace Amines and the Brain. (Eds. Usdin, E. and Sandler, M.) Marcel Dekker, Inc., New York, 120.Google Scholar
Boulton, A.A. (1974). Amines and theories in psychiatry. Lancet, 2, 7871.Google ScholarPubMed
Boulton, A.A. (1976). In, Trace Amines and the Brain. (Eds. Usdin, E. and Sandler, M.) Marcel Dekker, Inc., New York, 2139.Google Scholar
Boulton, A.A. (1978). The tyramines: Functionally significant biogenic amines or metabolic accidents? Life Sci., 23, 659672.CrossRefGoogle ScholarPubMed
Boulton, A.A. (1979). Trace amines in the central nervous system. Int. Rev. Biochemistry, (Ed., Tipton, K.F.) 26, 179206.Google Scholar
Boulton, A.A. (1979a). The trace amines: Neurohumours (cytosolic pre- and/or postsynaptic, secondary, indirect?) Behav. Brain Sci., 2, 418.CrossRefGoogle Scholar
Boulton, A.A. and Baker, G. (1975). The subcellular distribution of β-phenylethylamine, /Myramine and tryptamine in rat brain. J. Neurochem., 25, 477481.CrossRefGoogle ScholarPubMed
Boulton, A.A. and Juorio, A.V. (1979). The tyramines: Are they involved in the psychoses? Biol. Psychiat., 14, 413419.Google ScholarPubMed
Boulton, A.A. and Juorio, A.V., Philips, S.R. and Wu, P.H. (1977). Effects of reserpine and 6-hydroxydopamine on the levels of some arylalkylamines in rat brain. Brit. J. Pharmac, 59, 209214.CrossRefGoogle Scholar
Bradley, C. (1937). The behavior of children receiving benzedrine. Am. J. Psychiat., 94, 577.CrossRefGoogle Scholar
Connell, P.H. (1958). In, Amphetamine Psychosis. Chapman and Hall, London.Google Scholar
Coursey, R.D., Buchsbaum, M.S. and Murphy, D.L. (1979). Platelet MAO activity and evoked potentials in the identification of subjects biologically at risk for psychiatric disorders. Brit. J. Psychiat., 134, 372381.CrossRefGoogle ScholarPubMed
Dismukes, K. (1979). New concepts of molecular communication among neurones. Behav. Brain Sci., 2, 409448.CrossRefGoogle Scholar
Dyck, L.E., Boulton, A.A. and Jones, R.S.G. (1980). A comparison of the effects of methylphenidate and amphetamine on the simultaneous release of dopamine and p-tyramine or m-tyramine from rat striatal slices. Eur. J. Pharmacol, (in press)CrossRefGoogle ScholarPubMed
Faurbye, A. (1968). The role of amines in the aetiology of schizophrenia. Comp. Psychiat., 9, 155177.CrossRefGoogle ScholarPubMed
Henwood, R.W., Boulton, A.A. and Phillis, J.W. (1979). Iontophoretic studies of some trace amines in the mammalian CNS. Brain Res., 164, 347351.CrossRefGoogle ScholarPubMed
Huebert, N. (1980). Metabolism and excretion of some trace amines in the rat and the human. Ph.D. thesis. University of Saskatchewan.Google Scholar
Jones, R.S.G. and Boulton, A.A. (1980). Interactions between para-tyramine, meta-tyramine or βJ-phenylethylamine and dopamine on single neurones in the cortex and caudate nucleus of the rat. Can. J. Physiol, and Pharmacol.. 58, 222227.CrossRefGoogle ScholarPubMed
Juorio, A.V. (1979). Effect of stress and L-DOPA administration on mouse striatal tyramine and homovanillic acid levels. Brain Res., 179, 186189.CrossRefGoogle ScholarPubMed
Juorio, A.V. (1979a). Drug-induced changes in the formation, storage and metabolism of tyramine in the mouse. Brit. J. Pharmac, 66, 377384.CrossRefGoogle ScholarPubMed
Mosnaim, A.A. and Wolf, M.E. (1978). In, βJ-Phenyleihylamine: A Metabolically and Pharmacologically Active Amine. Marcel Dekker, Inc., New York.Google Scholar
Sandler, M. and Reynolds, G.P. (1976). Does phenylethylamine cause schizophrenia? Lancet, 1, 7071.CrossRefGoogle ScholarPubMed
Slingsby, J.M. (1975). Factors affecting urinary excretion of arylalkylamines in a randomly selected psychiatric population. Ph.D. thesis, University of Saskatchewan.Google Scholar
Wyatt, R.J., Gillin, J.C. and Stoff, D.M. (1977). In, Neuroregulators and Psychiatric Disorders. (Eds. Usdin, E., Hamburg, D.A. and Barchas, J.A.) Oxford University Press, New York.Google Scholar