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Tissue Lipids in Acute Acrylamide Intoxicated Rats

Published online by Cambridge University Press:  18 September 2015

Y.S. Huang ,
P. Wong ,
D. Blache ,
A. Barbeau  and
J. Davignon
Y.S. Huang
Affiliation:
Clinical Research Institute of Montreal
P. Wong
Affiliation:
Clinical Research Institute of Montreal
D. Blache
Affiliation:
Clinical Research Institute of Montreal
A. Barbeau
Affiliation:
Clinical Research Institute of Montreal
J. Davignon
Affiliation:
Clinical Research Institute of Montreal
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Abstract:

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A preliminary survey of tissue lipid composition in acrylamide intoxicated rats is reported. The animals were injected intraperitoneally with acrylamide 50 mg/kg body weight per day for 10 days. Liver cholesterol, mainly in the ester fraction, was decreased in treated rats. When fatty acid composition of liver cholesterol esters was examined, the proportions of linoleate and stearate were found to be decreased and were compensated by the increase of palmitate. Atrophy of epididymal fat pad resulted in severe triglyceride depletion and a relative increase in the proportion of phospholipids and cholesterol. There was also a reduction of linoleate, palmitate and palmitoleate in triglycerides and phospholipids of this tissue. There were, however, only minor changes in the fatty acid profile of the sciatic nerve.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 9 , Issue 2 , May 1982 , pp. 181 - 184
Copyright
Copyright © Canadian Neurological Sciences Federation 1982

References

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