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TGF-beta 1 Codon 10 Polymorphism is Associated with Cerebral SVD

Published online by Cambridge University Press:  02 December 2014

Hong-miao Tao ,
Guo-zhong Chen ,
Xiao-dong Lu ,
Xiao-gang Hu ,
Gan-ping Chen  and
Bei Shao
Hong-miao Tao*
Affiliation:
School of Medicine, Jinhua College of Profession & Technology
Guo-zhong Chen
Affiliation:
School of Medicine, Jinhua College of Profession & Technology
Xiao-dong Lu
Affiliation:
Department of Clinical Laboratory, Jinhua Central Hospital
Xiao-gang Hu
Affiliation:
Department of Radiology, Jinhua Central Hospital
Gan-ping Chen
Affiliation:
Department of Neurology, Jinhua People's Hospital, Jinhua
Bei Shao
Affiliation:
Cerebrovascular Unit, Department of Neurology, the First Affiliated Hospital, Wenzhou Medical College, Wenzhou, Zhejiang Province, the People's Republic of China
*
School of Medicine, Jinhua College of Profession & Technology, Jinhua, 321007, Zhejiang Province, The People's Republic of China.
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Abstract

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Background:

To clarify the role of inflammation in the pathogenesis of cerebral small vessel disease (SVD), we investigated whether the gene encoding transforming growth factor-beta 1(TGF-beta 1) is a risk factor for cerebral SVD as a whole, and for two different SVD subtypes.

Methods:

TGF-beta 1 codon10 (T+29C) genotype was determined in 441 Chinese patients (313 male and 128 female) with cerebral SVD and 450 control subjects (326 male and 124 female). Cerebral SVD patients were retrospectively classified into two groups based on neuroimaging findings: lacunar infarction group with 112 patients and ischaemic leukoaraiosis group with 329 patients.

Results:

Subjects carrying TT homozygote were susceptible to cerebral SVD [adjusted odds ratio (OR) =1.44, 95% confidence interval (CI), 1.05-1.98; P=0.026]. Further analysis of SVD subtypes revealed a moderate association with the ischaemic leukoaraiosis group [OR= 1.60, 95% CI, 1.14-2.25; P=0.007].

Conclusions:

Codon 10 of TGF-beta 1 might be a risk factor for SVD, specifically in ischaemic leukoaraiosis phenotype.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 38 , Issue 6 , November 2011 , pp. 869 - 873
Copyright
Copyright © The Canadian Journal of Neurological 2011

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