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Taurine Decreases Lesion Severity In the Hearts of Cardiomyopathy Hamsters

Published online by Cambridge University Press:  18 September 2015

Jamshid Azari ,
Peter Brumbaugh ,
André Barbeau  and
Ryan Huxtable
Jamshid Azari
Affiliation:
Departments of Pharmacology and Pathology, College of Medicine, University of Arizona, Health Sciences Center, Tuscon and the Department of Neurobiology, Clinical Research Instituteof Montreal
Peter Brumbaugh
Affiliation:
Departments of Pharmacology and Pathology, College of Medicine, University of Arizona, Health Sciences Center, Tuscon and the Department of Neurobiology, Clinical Research Instituteof Montreal
André Barbeau*
Affiliation:
Departments of Pharmacology and Pathology, College of Medicine, University of Arizona, Health Sciences Center, Tuscon and the Department of Neurobiology, Clinical Research Instituteof Montreal
Ryan Huxtable
Affiliation:
Departments of Pharmacology and Pathology, College of Medicine, University of Arizona, Health Sciences Center, Tuscon and the Department of Neurobiology, Clinical Research Instituteof Montreal
*
Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec, Canada, H2W 1R7
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Summary:

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Cardiomyopathic Syrian hamsters develop necrotic lesions consequent upon calcium overload from 60 days of age onward. Taurine, given as a 0.1M solution in place of drinking water for one month prior to sacrifice of animals of initial age 35 days, decreased the severity of subsequently developing cardiac lesions by 40%. Calcium concentration in the heart was decreased by 57%. Magnesium and iron concentrations were unaltered. Taurine given in a similar manner for 4 months had a protective effect, decreasing lesion severity by 21% and calcium concentration by 35%. Magnesium concentrations were increased by 12%. Compared to randombred animals, cardiomyopathic hamsters at one and two months of age have the same concentrations of calcium, magnesium and iron in the quadrants of the heart, except in the left ventricle, which has significantly higher concentration of calcium. Calcium concentrations are 70%, 1320% and 2100% higher respectively in one month, two month and five month old animals. Five month old animals differ slightly but significantly in iron (17% decrease) and magnesium concentrations (17% increase).

Cardiomyopathic hamsters have insignificant differences in β-adrenergic receptor density compared to random-bred animals and have a significantly higher rate of taurine influx.

Type
Quebec Cooperative Study of Friedreich's Ataxia
Information
Canadian Journal of Neurological Sciences , Volume 7 , Issue 4 , November 1980 , pp. 435 - 440
Copyright
Copyright © Canadian Neurological Sciences Federation 1980

References

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